A5103160548- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Acute Myocardial Infarction Research
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Treatments and Mutations
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Cancer therapeutics and mechanisms
- Cancer, Hypoxia, and Metabolism
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
Imperial College London
2015-2025
Hammersmith Hospital
2015-2025
The London College
2011-2023
Complejo Hospitalario de Salamanca
2023
Centre de Recherche sur l'Inflammation
2022
Université Paris Cité
2022
Inserm
2022
Imperial Valley College
2019
Imperial College Healthcare NHS Trust
2010-2018
Centre of Experimental Medicine of the Slovak Academy of Sciences
2015
Current knowledge of risk assessment in survivors myocardial infarction is largely based on data gathered before the advent thrombolysis. It must be determined whether and to what extent available information proposed criteria prognostication are applicable thrombolytic era.We reassessed prediction 10,219 with follow-up (ie, 98% total) who had been enrolled GISSI-2 trial, relying a set prespecified variables. The 3.5% 6-month all-cause mortality rate these patients compared higher value 4.6%...
The overall rate of mortality due to ischemic heart disease is known increase progressively with age. We evaluated the relation between and age in patients first myocardial infarctions treated thrombolytic therapy.
Background Modulation of adaptive immunity may underscore the efficacy trans-arterial chemoembolization (TACE). We evaluated influence TACE on T-cell function by phenotypic lymphocyte characterization in samples patients undergoing surgery with (T+) or without (T-) prior-TACE treatment. Methods profiled intratumoral (IT), peritumoral (PT) and non-tumoral (NT) background tissue to evaluate regulatory CD4+/FOXP3+ (T-reg) immune-exhausted CD8+/PD-1+ T-cells across T+ (n=58) T− (n=61). performed...
Background Other than aspirin, there are few oral antithrombotic treatments with proven efficacy in patients acute coronary syndrome. In this report, we present the rationale, design and baseline characteristics of Clopidogrel Unstable angina to prevent Recurrent ischaemic Events (CURE) trial, which includes a meta-analysis effects thienopyridines vascular disease.
To evaluate lung changes in rheumatoid arthritis (RA).The authors reviewed the computed tomographic (CT) scans from 84 patients with RA a mean articular disease duration (+/- standard deviation) of 12 years +/- 8 (range, 0.3-45 years). Fifteen underwent sequential CT evaluation during 5-65-month follow-up (mean, 18 months).Thirty-eight (49%) had abnormal showing following abnormalities: (a) bronchiectasis and/or bronchiolectasis (n = 23, 30%), (b) pulmonary nodules 17, 22%), (c) subpleural...
AIMS: To investigate the expression of two cell cycle related antigens (proliferating nuclear antigen (PCNA) and Ki67 antigen) in a series breast cancers; possible correlations between PCNA labelling indexes (PCNA-LI Ki67-LI) their associations with other biological clinicopathological variables. METHODS: Ninety six ductal 10 lobular carcinoma specimens were investigated. Samples fixed formalin Methacarnoy for localisation PCNA. was immunostained on frozen sections. The PCNA-LI Ki67-LI...
Abstract BACKGROUND Syndecan‐1 is a transmembrane heparan sulphate proteoglycan that involved in cell–cell adhesion, organization of cell–matrix and regulation growth factor signaling. METHODS Specimens from 254 consecutive breast carcinoma (BC) cases (110 N0, 144 N1/2) with long‐term follow‐up (median, 95 months) were immunostained for syndecan‐1, estrogen receptor (ER), progesterone (PgR), p53; 154 cases, c‐erbB‐2 status was known. mRNA protein expression also evaluated 20 tissue samples...
Mycobacterium tuberculosis can cause lung tissue damage to spread, but the mechanisms driving this immunopathology are poorly understood. The breakdown of matrix involves MMPs, which have a unique ability degrade fibrillar collagens at neutral pH. To determine whether MMPs play role in (TB), we profiled and their inhibitors, inhibitor metalloproteinases (TIMPs), sputum bronchoalveolar lavage fluid from patients with TB symptomatic controls. MMP-1 concentrations were significantly increased...
Fibrosis is a common end point of many pathological processes affecting the myocardium and may alter myocardial relaxation properties. By measuring fibrosis with cardiac magnetic resonance diastolic function Doppler echocardiography, we sought to define influence on left ventricular function.Two hundred four eligible subjects from 252 consecutive undergoing late postgadolinium enhancement (LGE) echocardiography were investigated. Subjects normal exhibited no or minimal (median LGE score, 0;...
<h3>Background</h3> It is unknown whether lesions in human TB are hypoxic or this influences disease pathology. Human characterised by extensive lung destruction driven host matrix metalloproteinases (MMPs), particularly collagenases such as metalloproteinase-1 (MMP-1). <h3>Methods</h3> We investigated tissue hypoxia five patients with PET imaging using the tracer [<sup>18</sup>F]-fluoromisonidazole ([<sup>18</sup>F]FMISO) and immunohistochemistry. studied regulation of MMP secretion primary...
At least 30% of patients with primary resectable non-small cell lung cancer (NSCLC) will experience a relapse in their disease within 5 years following definitive treatment. Clinicopathological predictors have proved to be suboptimal identifying high-risk patients. We aimed establish whether inflammation-based scores offer an improved prognostic ability terms estimating overall (OS) and recurrence-free survival (RFS) cohort operable, early-stage NSCLC Clinicopathological, demographic...
Rationale: Tuberculosis kills more than 1.5 million people per year, and standard treatment has remained unchanged for 30 years. (TB) drives matrix metalloproteinase (MMP) activity to cause immunopathology. In advanced HIV infection, tissue destruction is reduced, but underlying mechanisms are poorly defined no current antituberculous therapy reduces host damage.Objectives: To investigate MMP in patients with TB without coinfection determine the potential of doxycycline inhibit MMPs decrease...
RNA-binding proteins (RBPs) bind to and post-transcriptionally regulate the stability of mRNAs. La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding known 5'-terminal oligopyrimidine tract (TOP) mRNA translation. Here, we show LARP1 complexed 3000 mRNAs enriched for cancer pathways. A prominent member interactome mTOR whose transcript stabilized by LARP1. At functional level, promotes cell migration, invasion, anchorage-independent growth in vivo tumorigenesis....
Abstract Resistance to 5-Fluoruracil (5-FU) has been linked elevated expression of the main target, thymidylate synthase (TYMS), which catalyses de novo pathway for production deoxythymidine monophosphate. The potent oncogenic forkhead box transcription factor, FOXM1 is regulated by E2F1 also controls TYMS. This study reveals a significant role in 5-FU resistance. Overexpression and knock-down studies colon cancer cells suggest importance TYMS regulation. ChIP global ChIP-seq data confirms...
Article10 February 2016Open Access Transparent process miR-515-5p controls cancer cell migration through MARK4 regulation Olivier E Pardo Corresponding Author Department of Surgery & Cancer, Division Imperial Centre for Translational and Experimental Medicine (ICTEM), College, Hammersmith Hospital Campus, London, UK Search more papers by this author Leandro Castellano Catriona Munro Yili Hu Oncology, College Healthcare NHS Trust, Charing Cross Hospital, Francesco Mauri Jonathan Krell Romain...
A central tenet of tuberculosis pathogenesis is that caseous necrosis leads to extracellular matrix destruction and bacterial transmission. We reconsider the underlying mechanism pathology demonstrate collagen may be a critical initial event, causing as opposed resulting from it. In human granulomas, regions map areas necrosis. mice, transgenic expression metalloproteinase 1 causes necrosis, pathological hallmark tuberculosis. Collagen principal difference between humanised mice wild-type...
Programmed cell death ligand-1 immunohistochemical detection (PD-L1 IHC) is a putative predictor of response to PD-1/PD-L1-targeted checkpoint inhibitors. However, there no gold standard assay in hepatocellular carcinoma (HCC). We evaluated 5 PD-L1 IHC platforms (E1LN3, 28-8, 22c3, SP263 and SP142) 100 HCCs reporting expression malignant (M) tumour-infiltrating immune cells (TICs) non-tumorous cirrhotic tissues (NTICs). found substantial inter-assay heterogeneity detecting M (R2 =...
Systemic inflammation is a hallmark of cancer, and it has pivotal role in hepatocellular carcinoma (HCC) development progression. We conducted retrospective study including 362 patients receiving immune check-point inhibitors (ICIs) across three continents, evaluating the influence neutrophiles to lymphocytes ratio (NLR), platelets (PLR), prognostic nutritional index (PNI) on overall (OS), progression free survival (PFS), radiologic responses. In our treated with immunotherapy, median OS PFS...