A5030394430- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- COVID-19 and healthcare impacts
- Neuroendocrine Tumor Research Advances
- Pleural and Pulmonary Diseases
- Neuroblastoma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Myasthenia Gravis and Thymoma
- Lung Cancer Treatments and Mutations
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Occupational and environmental lung diseases
- Tracheal and airway disorders
- Cancer Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Cardiac Imaging and Diagnostics
- Ultrasound in Clinical Applications
- Sarcoma Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Advances in Oncology and Radiotherapy
- Vascular Malformations and Hemangiomas
- Adrenal and Paraganglionic Tumors
- Radiation Dose and Imaging
- Respiratory Support and Mechanisms
- Lymphatic Disorders and Treatments
Fondazione IRCCS Istituto Nazionale dei Tumori
2017-2025
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2022
University of Birmingham
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
AstraZeneca (Brazil)
2020
Stryker (United Kingdom)
2020
Pfizer (United Kingdom)
2020
Cytisine, a partial agonist-binding nicotine acetylcholine receptor, is promising cessation intervention. We conducted single-center, randomized, controlled trial (RCT) in Italy to assess the efficacy and tolerability of cytisine as smoking therapy among lung cancer screening participants.
WHO classification of Thoracic Tumours defines lung carcinoid tumours (LCTs) as well-differentiated neuroendocrine neoplasms (NENs) classified in low grade typical (TC) and intermediate atypical carcinoids (AC). Limited data exist concerning protein expression morphologic factors able to predict disease aggressiveness. Though Ki-67 has proved be a powerful diagnostic prognostic factor for Gastro-entero-pancreatic NENs, its role NENs is still debated. A retrospective series 370 LCT from two...
Pulmonary typical carcinoids (TCs) are uncommon, well-differentiated neuroendocrine tumors of the lung that do not exhibit necrosis and have fewer than two mitoses per 2 mm2, as defined by current World Health Organization classifications. Despite their low-grade status favorable prognostic impact, protein expression profile morphological characteristics associated with tumor progression metastatic spread remain largely unidentified. Oncocytic spindle cell histological variants acknowledged...
<b><i>Background:</i></b> Little information is available concerning prognostic factors for bronchopulmonary large cell neuroendocrine carcinomas (BP-LCNECs) and even less known about combined LCNECs (Co-LCNECs). We investigated whether an integrated morphological, immunohistochemical, molecular approach could be used their evaluation. <b><i>Methods:</i></b> Morphological (including features), proliferative (mitotic count/Ki-67 index),...
According to World Health Organization guidelines, atypical carcinoids (ACs) are well-differentiated lung neuroendocrine tumours with 2-10 mitoses/2 mm2 and/or foci of necrosis (usually punctate). Besides morphological criteria, no further tools in predicting AC clinical outcomes proposed. The aim this work was identify novel factors able predict disease aggressiveness and progression. METHODS AND RESULTS: Three hundred-seventy were collected centrally reviewed by two expert pathologists....
Pulmonary large cell carcinoma (LCC) is an undifferentiated neoplasm lacking morphological, histochemical, and immunohistochemical features of small lung cancer, adenocarcinoma (ADC), or squamous (SCC). The available molecular information on this rare disease limited. This study aimed to provide integrated overview 16 cases evaluating the mutational asset 409 genes transcriptomic profiles 20,815 genes. Our data showed that TP53 was most frequently inactivated gene (15/16; 93.7%) followed by...
Background The management of subsolid nodules (SSNs) in lung cancer screening (LCS) is still a topic debate, with no current uniform strategy to deal these lesions at risk overdiagnosis and overtreatment. BioMILD LCS trial has implemented prospective conservative approach for SSNs, managing annual low-dose computed tomography nonsolid (NSNs) part-solid (PSNs) solid component <5 mm, regardless the size component. present study aims determine (LC) detection survival volunteers SSNs....
Body composition has been linked with clinical and prognostic outcomes in patients cancer cardiovascular diseases. analysis lung screening (LCS) is very limited. This study aimed at assessing the association of subcutaneous fat volume (SFV) density (SFD), measured on chest ultra-low dose computed tomography (ultra-LDCT) images by a fully automated artificial intelligence (AI)-based software, anthropometric characteristics LCS population.
Introduction: Poorly differentiated neuroendocrine carcinomas (NECs) are characterized by aggressive clinical course and poor prognosis. No reliable prognostic markers have been validated to date; thus, the definition of a specific NEC algorithm represents need. This study aimed analyze large case series validate factors identified in previous studies on gastro-entero-pancreatic lung NECs assess if further parameters can be isolated. Methods: A pooled analysis four retrospective was...
Combined small-cell lung cancer (C-SCLC) is composed of SCLC admixed with a non-small-cell component. They currently receive the same treatment as SCLC. The recent evidence that may belong to either two lineages, neuroendocrine (NE) or non-NE, different vulnerability specific cell death pathways such ferroptosis, opens new therapeutic opportunities also for C-SCLC.
The secreted products of the metastasis suppressor gene KiSS1 may represent useful biomarkers in non-small cell lung cancer (NSCLC) but their levels patients have remained poorly investigated. We previously found that forced expression decreased invasive capability NSCLC drug-resistant cells and a pro-apoptotic role for has been proposed head neck cancer. Thus, we designed translational investigation including pilot study to analyze liquid biopsies, vitro experiments explore biological...
Combined large cell neuroendocrine carcinoma (CoLCNEC) is given by the association of LCNEC with adeno or squamous any non-neuroendocrine carcinoma. Molecular bases CoLCNEC pathogenesis are scant and no standardized therapies defined.44 CoLCNECs: 26 adenocarcinoma (CoADC), 7 (CoSQC), 3 small (CoSCLC), 4 atypical carcinoid (CoAC) napsin-A positive (NapA+), were assessed for alterations in 409 genes transcriptomic profiling 20,815 genes.Genes altered included TP53 (n = 30), RB1 14) KRAS 13)....
There is growing evidence that inflammatory, immunologic, and metabolic status associated with cancer patients survival. Here, we built a simple algorithm to predict lung outcome. Perioperative routine blood tests (RBT) of cohort resectable primary (LC) were analysed. Inflammatory, profiles used create single (RBT index) predicting LC A concurrent metastases (LM) was validate the RBT index. Charts 2088 consecutive 1129 LM undergoing resection evaluated. Among parameters, C-reactive protein...
Background: Mutations in genes encoding one of the subunits succinate dehydrogenase (SDH) are involved pheochromocytoma (PHEO) and paraganglioma (PGL) development. Over last few years, such mutations have also been associated with non-chromaffin tumors. However, immunohistochemistry (IHC) on tumor tissue a study loss heterozygosity (LOH) aimed at demonstrating pathogenic role SDHx only employed cases. Case report: We describe case 19-year-old Caucasian man germline SDHB mutation, who...
Coronary artery calcification (CAC) is a well-known cardiovascular risk factor and reliable score to predict non-cancer survival. In the last year, CAC has been investigated in lung cancer (LC) screening, showing promising results terms of mortality assessment. Nevertheless, its role LC patients still be investigated. This study aims evaluate performance fully automated scoring predicting 5-year survival who underwent surgical resection for stage I LC. retrospective observational included...