A5039441119- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- BRCA gene mutations in cancer
- Thyroid Disorders and Treatments
- Head and Neck Anomalies
- Neuroendocrine Tumor Research Advances
- Global Cancer Incidence and Screening
- Meningioma and schwannoma management
- Ocular Oncology and Treatments
- Parathyroid Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Cancer Diagnosis and Treatment
- Clusterin in disease pathology
- Multiple Myeloma Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Ophthalmology and Eye Disorders
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cancer, Hypoxia, and Metabolism
- Chronic Lymphocytic Leukemia Research
- Salivary Gland Tumors Diagnosis and Treatment
- Cardiac tumors and thrombi
- S100 Proteins and Annexins
University of Catania
2015-2025
Ospedale Garibaldi
2015-2025
Policlinico Universitario di Catania
2023
Institut Gustave Roussy
2021
Abstract Context Differentiated thyroid cancer (DTC) has an excellent prognosis, but up to 20% of patients with DTC have disease events after initial treatment, indistinctly defined as persistent/recurrent disease. Objective To evaluate the prevalence and outcome “recurrent” (relapse being 12 months disease-free) compared “persistent” (present ab initio since diagnosis). Design Retrospective analysis in (1990 2016) 6.5 years mean follow-up. Setting Tertiary referral center for cancer....
Purpose: Adrenocortical cancer (ACC) is an aggressive tumor characterised by a high recurrence rate and poor response to treatment. This study analyses consecutive series of ACC patients evaluate the prognostic value various clinical pathological characteristics. Methods: We retrospectively evaluated 32 followed at our Medical Center from 1997 2015 age diagnosis, gender, functional status, stage type treatment with respect overall survival (OS) disease-free (DFS) as determined Kaplan–Meier...
Differentiated thyroid cancer (DTC) in thyroglossal duct cysts is uncommon. The requirement of total thyroidectomy and lymph node dissection still controversial. study was performed a referral center at an academic hospital. We conducted single retrospective consecutive series 26 patients with DTC cyst, all having undergone cyst resection thyroidectomy. Diagnostic modalities, surgical treatment, histopathological features, clinical outcome were included the study. Thyroglossal histotype...
Multiple endocrine neoplasia type 2 syndrome (MEN2) is a hereditary disease resulting from mutations of the rearranged during transfection (RET) protooncogene subclassified into MEN2A [medullary thyroid carcinoma (MTC), pheochromocytoma, and primary hyperparathyroidism] MEN2B (MTC, Marfanoid habitus, mucous neuromas, intestinal ganglioneuromatosis). Prophylactic thyroidectomy recommended in RET-mutated patients. The age at which it should be performed depends on aggressiveness mutation. This...
Introduction: little is known about sex differences in lenvatinib treatment safety and efficacy. Methods: real-word retrospective Italian multicenter study enrolling patients with radioiodine-refractory differentiated thyroid cancer treated lenvatinib. Results: 138 (64 females) were included, a median follow-up of 26 months (2-72). More men performed physical activities (34%vs17%, p=0.024). The frequency smoking alcohol consumption was higher (58%vs33%, p=0.003; 45%vs17%, p=0.001). We did...
To assess whether familial non-medullary thyroid cancer (FNMTC) represents an independent risk factor for increased aggressiveness of the tumor, as concern clinical presentation and long-term follow-up in respect sporadic differentiated (SDTC).Retrospective study; 1976-2014.Seventy-four FNMTC families (151 affected individuals): family relationship number members were evaluated. Clinical histopathological features outcome compared to that 643 SDTC patients followed same period according...
Background: Pediatric differentiated thyroid cancer (P-DTC) frequently presents with advanced disease. The study aim was to evaluate the outcome of P-DTC and a modified 2015 American Thyroid Association risk classification (ATA-R). Methods: A retrospective consecutive patients performed. ATA-R for used cut-off ≤ 5 N1a low-risk. could be excellent response (ER) (thyroglobulin < 1 ng/mL no evidence disease (EoD) at imaging), biochemical incomplete (BIR) ≥ EoD imaging) or structural (SIR)...
Pediatric thyroid cancer (TC) is rare but its incidence increasing. We analyzed and characteristics of pediatric TC in Sicily comparatively evaluated data from the volcanic non-volcanic areas.All incident (0-19 years) TCs between 2002-2009 were for area residence compared to adults.A total 54 differentiated (DTC) nine medullary diagnosed children 2002-2009. DTC age standardized rate world population (ASRw) was 0.8/105 females 0.2/105 males, with a higher (ASRw=1.4/105 females, 0.5/105 males)...
Abstract Objective To correlate clinical and pathological characteristics at diagnosis with patient long‐term outcomes to evaluate ongoing risk stratifications in a large series of paediatric differentiated thyroid cancers (DTC). Study design Retrospective analysis prognostic factors 124 patients DTC (age <19 years) followed up for 10.4 ± 8.4 years. Patients follow‐up >3 years (n = 104) were re‐classified 18 months after surgery on the basis their response therapy (ongoing...
Anaplastic thyroid cancer (ATC) is a rare but extremely aggressive of the thyroid, contributing up to 30-40% cancer-specific mortality. We analyzed ATC characteristics and survival rates in Sicily evaluate possible influence environmental factors. With this aim, data regarding incidences urban/rural industrial, iodine-deficient, volcanic vs control areas were compared as well from USA.Using Sicilian Register Thyroid Cancer (SRTC) database incidence, age, gender, tumor size histotype,...
Introduction The personalized management of differentiated thyroid cancer (DTC) is currently based on the postoperative TNM staging system and ATA risk stratification (RSS), both updated in 2018 2015, respectively. Purpose We aimed to evaluate impact last two editions RSS prediction persistent/recurrent disease a large series DTC patients. Patients methods Our prospective study included 451 patients undergone thyroidectomy for DTC. classified according (both VIII VII ed.) stratified them...
Multifocality in papillary thyroid cancer (PTC) is a common event, ranging from 18% to 87%. Additional multiple foci are frequently very small and generally detected pathology specimens. The mechanisms of intrathyroidal spread, its correlation with age, gender, tumour size, lymph node metastases remain unclear. Moreover, studies assessing the prognostic impact PTC multifocality have yielded non-univocal results. We aimed evaluate following: a) histopathological clinical characteristics...
Primary hyperparathyroidism (PHPT) is a common disorder due to parathyroid adenoma (PA) in over 85% of cases.Usually the PA has weight lower than 3.5 g; rare cases exceeding this are defined giant PA.In literature about 30 have been described, and only three was more 50 grams [1, 2].It still debated whether represents
Bortezomib, thalidomide, and dexamethasone (VTD) plus autologous stem cell transplantation has been the standard treatment in Europe for transplant-eligible (TE) patients (pt) with newly diagnosed multiple myeloma (NDMM) until monoclonal antibody daratumumab added. Approval of triplet comes from GIMEMA-MMY-3006 clinical trials (four 3-week cycles bortezomib 1.3 mg/m2 on days 1, 4, 8, 11; thalidomide 100 mg daily; 40 1 -4 9-12). However, some pt discontinue VTD because severe adverse events...
Background: Patients treated for paediatric/adolescent (P/A) neoplasia have a high incidence of both benign and malignant thyroid diseases. Given the sequelae, literature data show clinical benefit morpho-functional screening in cancer survivors careful lifetime follow-up. methods: The alterations was evaluated consecutive series 343 patients with chemotherapy (CHE) radiotherapy (RTE) or only CHE P/A tumours between 1976 2018 (mean age at time primary paediatric malignancy 7.8 ± 4.7 years)....