A5087267959- Cerebrovascular and Carotid Artery Diseases
- Aortic aneurysm repair treatments
- Vascular Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Neurogenesis and neuroplasticity mechanisms
- Genomics, phytochemicals, and oxidative stress
- Multiple Sclerosis Research Studies
- Glycosylation and Glycoproteins Research
- Esophageal Cancer Research and Treatment
- Abdominal vascular conditions and treatments
- Inflammatory Myopathies and Dermatomyositis
- Calcium signaling and nucleotide metabolism
- Neuroscience and Neuropharmacology Research
- Vascular anomalies and interventions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ginseng Biological Effects and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Oropharyngeal Anatomy and Pathologies
- Intestinal Malrotation and Obstruction Disorders
- Monoclonal and Polyclonal Antibodies Research
- Vascular Malformations Diagnosis and Treatment
University of Naples Federico II
2018-2024
University of Catania
2018-2024
University of Palermo
2014-2019
Ospedale Garibaldi
2018
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2015
The main dietary flavonoid quercetin, is known to preserve the integrity of gastrointestinal barrier and have anti-inflammatory, anti-cancer, anti-fibrotic, other beneficial properties. Many biological effects quercetin appear be associated modulation cell signaling pathways, rather than its antioxidant activity. In spite large number data available on molecular cellular mechanisms by which exerts effects, including protection intestinal function, there a lack about role this substance...
Chlorogenic acid (CGA), a polyphenol found mainly in coffee and tea, exerts antioxidant, anti-inflammatory anti-apoptotic effects at the gastrointestinal level. However, although CGA is known to cross blood–brain barrier (BBB), its on CNS are still unknown. Oligodendrocytes (OLs), myelin-forming cells CNS, main target demyelinating neuroinflammatory diseases such as multiple sclerosis (MS). We evaluated roles of M03-13, an immortalized human OL cell line. that reduces intracellular...
Background: We proposed the term “UIPAF” to define patients with Usual Interstitial Pneumonia (UIP) associated only one domain of classification called “Interstitial Autoimmune Features” (IPAF). The objective this study was evaluate clinical presentation and prognosis UIPAF patients, compared two cohorts, composed IPAF idiopathic pulmonary fibrosis (IPF) respectively. Methods: were enrolled as IPAF, UIPAF, or IPF based on clinical, serological, radiological data evaluated by a...
Multiple sclerosis (MS) is an autoimmune chronic disease characterized by inflammation and demyelination of the central nervous system (CNS). Despite numerous studies conducted, valid biomarkers enabling a definitive diagnosis MS are not yet available. The aim our study was to identify marker from blood sample ease MS. In this study, since there evidence connecting serotonin pathway MS, we used ELISA (Enzyme-Linked Immunosorbent Assay) detect serum MS-specific auto-antibodies (auto-Ab)...
Inside the adult CNS, oligodendrocyte progenitor cells (OPCS) are able to proliferate, migrate and differentiate into mature oligodendrocytes (OLs) which responsible for production of myelin sheet energy supply neurons. Moreover, in demyelinating diseases, OPCs recruited lesion areas where they undergo differentiation synthesis. Serotonin (5-hydroxytryptamine, 5-HT) is involved OLs’ development myelination, but so far molecular mechanisms or effects 5-HT on mitochondria function have not yet...
Abstract Objective To correlate clinical and pathological characteristics at diagnosis with patient long‐term outcomes to evaluate ongoing risk stratifications in a large series of paediatric differentiated thyroid cancers (DTC). Study design Retrospective analysis prognostic factors 124 patients DTC (age <19 years) followed up for 10.4 ± 8.4 years. Patients follow‐up >3 years (n = 104) were re‐classified 18 months after surgery on the basis their response therapy (ongoing...
Abstract Purpose Lung cancer screening (LCS) by low-dose computed tomography (LDCT) demonstrated a 20–40% reduction in lung mortality. National stakeholders and international scientific societies are increasingly endorsing LCS programs, but translating their benefits into practice is rather challenging. The “Model for Optimized Implementation of Early Cancer Detection: Prospective Evaluation Of Preventive HEalth” (PEOPLHE) an Italian multicentric program aiming at testing feasibility...
Reactive oxygen species (ROS) participate in the T-cell activation processes. ROS-dependent regulatory networks are usually mediated by peroxides, which more stable and able to freely migrate inside cells. Superoxide dismutase (SOD)-1 represents major physiological intracellular source of peroxides. We found that antigen-dependent a triggering element for SOD-1 production secretion human T lymphocytes. A deranged proinflammatory response characterizes pathogenesis multiple sclerosis (MS)....
Abstract Spinal cord malformations, known as “spinal dysraphisms” encompass a diverse range of spinal abnormalities characterized by incomplete median closure mesenchymal, bone, and nervous tissues. They are classified “open,” involving both the overlying tissues, or “occult,” affecting only system structures. Neurulation along neural tube, from rostral to caudal portions, primarily cause these malformations. Clinical presentations vary, including cutaneous manifestations like hemangiomas,...
Abstract Arterial tortuosity syndrome (ATS) is a very rare autosomal recessive disorder that affects the connective tissue. The incidence of ATS not well known and to date only 106 patients have been described in literature. medium large size arteries, leading widespread elongation intensification average vessel tortuousness, responsible several loops kinks. Like other tissue disorders, can present with joint laxity, hernias, pectus excavatum, scoliosis or musculoskeletal abnormalities,...
Arteriography with contrast medium (CM) injection is normally employed to visualise the lowest renal artery during endovascular aneurysm repair (EVAR). Intravascular ultrasound (IVUS) has been proposed as an alternative, real-time imaging diagnostic technique arteriography. In this study, we evaluated feasibility of EVAR using Anaconda repositionable aortic stent graft (Vascutek) assisted by IVUS (Volcano Visions, Philips) intraluminal navigation without CM. From January 2016 December 2017,...