A5026683065- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Cardiac Imaging and Diagnostics
- Sarcoidosis and Beryllium Toxicity Research
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- COVID-19 diagnosis using AI
- Advanced X-ray and CT Imaging
- Ultrasound in Clinical Applications
- Liver Disease and Transplantation
- Esophageal Cancer Research and Treatment
- Radiation Dose and Imaging
- Systemic Sclerosis and Related Diseases
- Alcohol Consumption and Health Effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Disease and Adiposity
- COVID-19 and healthcare impacts
- Occupational and environmental lung diseases
- Soft tissue tumor case studies
- Renal cell carcinoma treatment
University of Parma
2019-2025
Fondazione IRCCS Istituto Nazionale dei Tumori
2021-2025
Vita-Salute San Raffaele University
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Brigham and Women's Hospital
2024
Lung Institute
2024
St. Paul's Hospital
2024
Creative Commons
2023
Swiss National Science Foundation
2023
University of Bern
2023
A new coronavirus (severe acute respiratory syndrome 2, SARS-CoV-2) is contaminating the world; it has originated from China and been infecting people since December 2019.1 Like other viruses, SARS-CoV-2 harbors in human cells results different degrees of cellular damage. The rapid diffusion brutal effect this virus have caused to be rapidly ranked as a global threat, currently known disease (COVID-19)2 defined pandemic by World Health Organization on March 11, 2020. clinical presentation...
Cytisine, a partial agonist-binding nicotine acetylcholine receptor, is promising cessation intervention. We conducted single-center, randomized, controlled trial (RCT) in Italy to assess the efficacy and tolerability of cytisine as smoking therapy among lung cancer screening participants.
To assess automated coronary artery calcium (CAC) and quantitative emphysema (percentage of low attenuation areas [%LAA]) for predicting mortality lung cancer (LC) incidence in LC screening. explore correlations between %LAA, CAC, forced expiratory value 1 second (FEV ) the discriminative ability %LAA airflow obstruction.Baseline low-dose computed tomography scans BioMILD trial were analyzed using an artificial intelligence software. Univariate multivariate analyses performed to estimate...
Micro-computed tomography (µCT)-based imaging plays a key role in monitoring disease progression and response to candidate drugs various animal models of human disease, but manual image processing is still highly time-consuming prone operator bias. Focusing on an established mouse model bleomycin (BLM)-induced lung fibrosis we document, here, the ability fully automated deep-learning (DL)-based improve speed-up segmentation precise measurement morphological functional biomarkers both whole...
To compare Low-Dose Computed Tomography (LDCT) with four different Ultra-Low-Dose (ULDCT) protocols for PN classification according to the Lung Reporting and Data System (LungRADS).Three hundred sixty-one participants of an ongoing lung cancer screening (LCS) underwent single-breath-hold double chest (CT), including LDCT (120kVp, 25mAs; CTDIvol 1,62 mGy) one ULDCT among: fully automated exposure control ("ULDCT1"); fixed tube-voltage current patient size ("ULDCT2"); hybrid approach...
Hypersensitivity pneumonitis (HP) is a diffuse parenchymal lung disease (DLPD) characterized by complex interstitial damage with polymorphic and protean inflammatory aspects affecting tissue targets including small airways, the interstitium, alveolar compartments vascular structures. HP shares clinical often radiological features other diseases in acute or chronic forms. In its natural temporal evolution, if specific therapy not initiated promptly, leads to progressive fibrotic reduced...
Airway-related quantitative imaging biomarkers are crucial for examination, diagnosis, and prognosis in pulmonary diseases. However, the manual delineation of airway structures remains prohibitively time-consuming. While significant efforts have been made towards enhancing automatic modelling, current public-available datasets predominantly concentrate on lung diseases with moderate morphological variations. The intricate honeycombing patterns present tissues fibrotic disease patients...
AIM: To examine the role of [18F]FDG PET/CT for assessing response to immunotherapy in patients with some solid tumors. METHODS: Data recorded a multicenter (n = 17), retrospective database between March and November 2021 were analyzed. The sample included confirmed diagnosis tumor who underwent serial (before after one or more cycles immunotherapy), >18 years age, had follow-up at least 12 months their first scan. Patients enrolled clinical trials without cancer excluded. authors...
Coronary artery calcium (CAC) is a known risk factor for cardiovascular (CV) events and mortality but not yet routinely evaluated in low-dose computed tomography (LDCT)-based lung cancer screening (LCS). The present analysis explored the capacity of fully automated CAC scoring to predict 12-year Multicentric Italian Lung Detection (MILD) LCS trial. study included 2239 volunteers MILD trial who underwent baseline LDCT from September 2005 January 2011, with median follow-up 190 months. score...
<div>AbstractPurpose:<p>To uncover the underpinnings of acquired resistance (AR) to immunotherapy (IO), we determined whether distinctive clinicopathologic, radiomic, and peripheral blood (PB) immune-inflammatory features reflect oligo- systemic (sys)-AR in patients with advanced non–small cell lung cancer (NSCLC) undergoing immune checkpoint inhibitor therapy.</p>Experimental Design:<p>On 105 consecutive IO-treated NSCLC, PB immunophenotypes, cytokines, CT-derived...
<p>Delta radiomic profiling of oligoAR and sysAR patients</p>
<p>Survival outcome of the overall study population</p>
<p>Statistically different baseline radiomic features in oligoAR vs sysAR patients</p>
<p>Survival outcome within oligoAR and sysAR subgroups</p>
<p>Supplementary Materials and Methods</p>
<p>Blood immune-inflammatory features in patients developing acquired resistance to IO</p>
<p>Principal component analysis of CT technical parameters</p>
<p>Gating strategy adopted for flow cytometric (FACS) analyses</p>