A5077552454- Smoking Behavior and Cessation
- Air Quality and Health Impacts
- Noise Effects and Management
- Air Quality Monitoring and Forecasting
- Vehicle emissions and performance
- Lung Cancer Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Pain Management and Opioid Use
- Lung Cancer Treatments and Mutations
- Indoor Air Quality and Microbial Exposure
- Lung Cancer Diagnosis and Treatment
- Climate Change and Health Impacts
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Nutritional Studies and Diet
- Nicotinic Acetylcholine Receptors Study
- Asthma and respiratory diseases
- Obesity, Physical Activity, Diet
- Atmospheric chemistry and aerosols
- COVID-19 and healthcare impacts
- School Health and Nursing Education
- Testicular diseases and treatments
- Inhalation and Respiratory Drug Delivery
Fondazione IRCCS Istituto Nazionale dei Tumori
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Conference Board
2019
University of Belgrade
2019
The Maria Sklodowska-Curie National Research Institute of Oncology
2019
IRCCS San Camillo Hospital
2019
Uniwersytet Kaliski im. Prezydenta Stanisława Wojciechowskiego
2019
Lega Italiana per la Lotta ai Tumori
2013
University of Milan
2013
Società Italiana di Medicina Generale
2006-2011
PURPOSE: To evaluate the clinical benefits of switching from morphine to oral methadone in patients who experience poor analgesia or adverse effects morphine. PATIENTS AND METHODS: Fifty-two consecutive cancer receiving but with uncontrolled pain and/or moderate severe opioid were switched administered every 8 hours using different dose ratios. Intensity and assessed daily, symptom distress score (DS) was calculated before after switching. RESULTS: Data analyzed for 50 patients. Switching...
The increasing popularity of electronic cigarettes (e-cigarettes) and, more recently, the new “heat-not-burn” tobacco products (iQOS) as alternatives to traditional has necessitated further documentation and research into composition potential health risks/benefits these devices. In a recent study, we compared second-hand exposure particulate metals organic compounds from e-cigarettes cigarettes, by conducting continuous time-integrated measurements in an indoor environment, followed...
Emission of organic compounds and metals from electronic cigarettes are quantified.
Population data on tobacco use and its determinants require continuous monitoring careful inter-country comparison. We aimed to provide the most up-to-date estimates smoking from a large cross-sectional survey, conducted in selected European countries.
Cytisine, a partial agonist-binding nicotine acetylcholine receptor, is promising cessation intervention. We conducted single-center, randomized, controlled trial (RCT) in Italy to assess the efficacy and tolerability of cytisine as smoking therapy among lung cancer screening participants.
IntroductionThe National Lung Screening Trial has achieved a 7% reduction in total mortality with low-dose computed tomography (LDCT) screening as compared the chest radiography arm. Other randomized trials are under way, comparing LDCT no intervention. None of these studies was designed to investigate impact smoking habits on outcome. In present study, we tested effect stopping overall participants undergoing repeated for many years.MethodsBetween 2000 and 2010, 3381 smokers aged 50 years...
Air pollution is a common alibi used by adolescents taking up smoking and smokers uncertain about quitting. However, environmental tobacco smoke (ETS) causes fine particulate matter (PM) indoor exceeding outdoor limits, while new engines fuels have reduced emissions cars. Data comparing PM emission from ETS recently released diesel car are presented.A 60 m3 garage was chosen to assess three smouldering cigarettes (lit sequentially for 30 minutes) TDCi 2000cc, idling minutes.Particulate...
Abstract Smokers have higher levels of C-Reactive Protein (CRP) compared to never smokers. The role smoking cessation on CRP is still under debate. Using data from two screening studies conducted in Italy 2000–2010 3050 heavy smokers (including 777 ex-smokers), we estimated multivariate odds ratios (OR) for high (i.e. ≥2 mg/L) according status. Moreover, a longitudinal analysis based 975 current smokers, with second measurement after an average study period 3.4 years, the changes cessation....
The TackSHS project aims to comprehensively elucidate the impact that exposure second-hand smoke (SHS) from cigarettes and aerosols (SHA) electronic have on respiratory health of European population according socioeconomic characteristics other determinants.The involves a series coordinated studies carried out by 11 academic public organisations six countries. will investigate: a) determinants SHS SHA assessed at individual level (surveys representative general samples) in common...
Electronic cigarette (e-cigarette) use emits potentially hazardous compounds and deteriorates indoor air quality. Home is a place where e-cigarettes may frequently be used amid its increasing prohibition in public places. This study assessed the real-life scenario of bystanders' exposure to secondhand e-cigarette aerosol (SHA) at home. A one-week observational was conducted within TackSHS project four countries (Greece, Italy, Spain, United Kingdom) 2019 including: 1) homes users living...
Abstract E-cigarettes and heated tobacco products have been marketed as safer alternatives to traditional cigarettes, leading consumers believe that they will reduce health risks. However, the scientific evidence collected so far calls this hypothesis into question. Their use a means of smoking cessation has not only led unequivocal results on their effectiveness, but some studies even suggest could increase risk initiation or relapse nicotine addiction. Furthermore, research indicates both...
Abstract Background Oral mucositis (OM)‐related pain affects most patients with head and neck cancer during treatments, but its management is not standardized. Methods We retrospectively collected data about the opioid therapy used for OM‐induced in all oropharyngeal treated chemoradiotherapy (CRT) between 2009 2013. To compare different opioids, a conversion into oral morphine equivalent daily dose (OMEDD) was performed. The highest OMEDD (h‐OMEDD) opioids' weekly increase were associated...
Electronic cigarettes may be safer than conventional as they generate less indoor pollution in terms of particulate matter (PM); however, recent findings experimental conditions demonstrated that secondhand exposure to PM expected from e-cigarette smoking. The aim the present study was investigate emission generated by e-cigarettes and normal under real-life conditions.Real-time measurement comparison ultrafine particles (UFP) electronic with without nicotine a 50 m3 office an Italian...
The increasing survival of patients with breast cancer has prompted the assessment mortality due to all causes death in these patients. We estimated absolute risks from different causes, useful for health-care planning and clinical prediction, as well cause-specific hazards, hypothesis generation on etiology risk factors.Using data population-based registries we performed a retrospective study cohort women diagnosed primary cancer. carried out competing-cause analysis computing cumulative...
According to the data of literature, prevalence pain in cancer patients at various stages disease and settings care range from 38 51%, with an increase up 74% advanced terminal stages. Despite published World Health Organization (WHO) guidelines for management, 42 51% receive inadequate analgesia 30% no analgesics all. A 3-year Research Project “Towards a Pain-free Hospital”, which began one year ago, is ongoing National Cancer Institute Milan. The research organized three subsequent steps....
Background: Tobacco smoking entails inhaling millions of fine particles with each puff, and it is intuitive that after a cigarette will take certain time to washout residual tobacco smoke (RTS) from the lungs subsequent breaths. Objectives: To study 0.3–1.0 µm last puff in 10 volunteer smokers by using equipment capable measuring particle concentration real exhaled air. Result: Mean (standard deviation (SD)) lung RTS was 58.6 (23.6) s, range 18–90 corresponded 8.7 (4.6) breathings. The...
Aims and Background The time of lung cancer screening may provide the ideal setting to discuss initiate a smoking cessation plan that includes pharmacologic aids. No studies date have fully investigated potential effectiveness such combined approach. Methods We prospectively evaluated biochemically verified 1-year continuous abstinence rate from 187 persistent smokers enrolled within Multicentric Italian Lung Detection Trial (MILD), who received aid quit with varenicline along behavioral...
Despite the robust evidence of an excess risk coronavirus disease 2019 (COVID-19) severity and mortality in ever smokers, debate on role current ex-smokers COVID-19 progression remains open. Limited or no data are available link between electronic cigarette (e-cigarette), heated tobacco product (HTP) second-hand smoke (SHS) exposure progression. To fill this knowledge gap, we undertook COvid19 SMOking ITaly (COSMO-IT) study.