A5072051904- MicroRNA in disease regulation
- RNA modifications and cancer
- Genomics, phytochemicals, and oxidative stress
- Air Quality and Health Impacts
- Atmospheric chemistry and aerosols
- Lung Cancer Research Studies
- Air Quality Monitoring and Forecasting
- Pharmaceutical studies and practices
- Viral Infections and Outbreaks Research
- Smoking Behavior and Cessation
- Radioactivity and Radon Measurements
- Atmospheric Ozone and Climate
- Ethics and Legal Issues in Pediatric Healthcare
- X-ray Spectroscopy and Fluorescence Analysis
- Carcinogens and Genotoxicity Assessment
- interferon and immune responses
- Cancer-related Molecular Pathways
- Atmospheric and Environmental Gas Dynamics
- Heavy metals in environment
- Water Quality and Pollution Assessment
- Energy and Environment Impacts
- Chromatin Remodeling and Cancer
- Bacillus and Francisella bacterial research
- Cancer-related molecular mechanisms research
- Healthcare and Environmental Waste Management
Cooper Medical School of Rowan University
2024-2025
University of North Carolina at Chapel Hill
2021-2024
Cooper University Hospital
2024
Cooper University Health Care
2024
UNC Lineberger Comprehensive Cancer Center
2022
Heidelberg University
2021
University of Maryland, College Park
2015-2018
University of Wisconsin–Madison
2012-2016
Madison Group (United States)
2014
This study quantifies the present-day global and regional distributions (2010–2014) trends (2000–2014) for five ozone metrics relevant short-term long-term human exposure. These metrics, calculated by Tropospheric Ozone Assessment Report, are: 4th highest daily maximum 8-hour (4MDA8); number of days with MDA8 > 70 ppb (NDGT70), SOMO35 (annual Sum Means Over 35 ppb) two seasonally averaged (3MMDA1; AVGMDA8). were explored at monitoring sites worldwide, which classified as urban or...
In support of the first Tropospheric Ozone Assessment Report (TOAR) a relational database global surface ozone observations has been developed and populated with hourly measurement data enhanced metadata. A comprehensive suite products including standard statistics, health vegetation impact metrics, trend information, are made available through common portal web interface. These form basis TOAR analyses focusing on human health, vegetation, climate relevant issues, which part this special...
Emission of organic compounds and metals from electronic cigarettes are quantified.
Abstract. Measuring the chemical composition of airborne particulate matter (PM) can provide valuable information on concentration regulated toxic metals, support modelling approaches for source detection and assist in identification validation abatement techniques. Undertaking these at a high time resolution (1 h or less) enables receptor techniques to be more robustly linked emission processes. This study describes comprehensive laboratory field evaluation x-ray fluorescence (XRF)...
Abstract Aberrant activation of the NRF2/NFE2L2 transcription factor commonly occurs in head and neck squamous cell carcinomas (HNSCC). Mouse model studies have shown that NRF2 alone does not result cancer. When combined with classic oncogenes at right dose, promotes tumor initiation progression. Here we deleted suppressor genes p16INK4A p53 (referred to as CP mice), which are lost human HNSCC, presence a constitutively active NRF2E79Q mutant (CPN mice). expression CPN mice resulted...
Abstract Lung cancer continues to be the leading cause of cancer-related mortality in United States, with lung adenocarcinoma (LUAD) representing most common histological subtype. Clinical evidence has demonstrated that tumor plasticity—, transformation between subtypes—, plays a crucial role development resistance chemotherapy and targeted therapies. Hyperactivation NRF2, transcription factor normally protects cells from oxidative damage, is implicated various types therapies including...
<title>Abstract</title> The NRF2 signaling pathway promotes tumor initiation, progression and resistance to chemotherapy, radiation therapy immune checkpoint inhibitors. mechanisms underlying the biology of NRF2-active tumors are varied, include altered cellular metabolism, a reductive shift in redox state, immunosuppression. Here we determined molecular phenotypic impact activation on two human non-small cell lung cancer (NSCLC) models. Inducible expression NRF2<sup>E79Q</sup>, common...
There is a paucity of data on how gene expression enables identification individuals who are at risk exposure to carcinogens from e-cigarette (e-cig) vaping; and human vaping behaviors modify these exposures. This pilot study aimed identify genes regulated acute e-cig using RT-qPCR. Three subjects (2M 1F) made three visits the lab (nTOT = 9 visits); buccal blood samples were collected before immediately after scripted 20 puffs 18 samples); topography in each session. Subjects used their own...
The distribution of dissolved and particulate forms 49 elements was investigated along transect the Tigris River (one major rivers world) within Baghdad city in its tributary (Diyala River) from 11 to 28 July 2011. SF-ICP-MS used measure total filterable at 17 locations transect, two samples Diyala River, one sample confluence rivers. calculated were determine particle-partition coefficients metals. No changes concentrations down river transect. Dissolved phases dominated physical speciation...
Our objective was to characterize physical properties and semivolatile harmful potentially constituent yields in the mainstream smoke (MSS) of 4 popular little cigars compared 3R4F reference cigarette.
<p>Figure S4 shows scatterplots Protein abundances measured by targeted protein mass spectrometry in CP and CPN oral cavity tissues.</p>
<p>Table S3 shows IHC-NRF2 score in control tissues from CP & CPN mice treated with TMX</p>
<p>Table S3 shows IHC-NRF2 score in control tissues from CP & CPN mice treated with TMX</p>
<div>Abstract<p>Aberrant activation of the NRF2/NFE2L2 transcription factor commonly occurs in head and neck squamous cell carcinomas (HNSCC). Mouse model studies have shown that NRF2 alone does not result cancer. When combined with classic oncogenes at right dose, promotes tumor initiation progression. Here we deleted suppressor genes <i>p16<sup>INK4A</sup></i> <i>p53</i> (referred to as CP mice), which are lost human HNSCC, presence a...
<p>Histologic profile of normal and epithelial lesions the oral mucosa from CP CPN mice. Normal epithelium (CP; <b>A</b>); hyperplasia with hyperkeratosis (CPN; <b>B</b>); (<b>C</b>); squamous cell carcinoma <b>D</b>). Scale bar = 50 µm. Images were taken using an Olympus DP38 digital camera on BX46 microscope.</p>
<p>Table S1 shows mouse SIL catalogue.</p>