A5057664702- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Thyroid Cancer Diagnosis and Treatment
- Liver Disease and Transplantation
- Thyroid Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Chronic Lymphocytic Leukemia Research
- Adrenal Hormones and Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Liver Diseases and Immunity
- Monoclonal and Polyclonal Antibodies Research
- Pancreatitis Pathology and Treatment
- Brucella: diagnosis, epidemiology, treatment
- Gallbladder and Bile Duct Disorders
- Diet and metabolism studies
- Head and Neck Surgical Oncology
- Immunodeficiency and Autoimmune Disorders
- Microscopic Colitis
- HIV/AIDS drug development and treatment
- Diabetes and associated disorders
- Cancer, Lipids, and Metabolism
- Vascular anomalies and interventions
- Bone Tumor Diagnosis and Treatments
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2022
Casa Sollievo della Sofferenza
2012-2022
Institute of Molecular and Cell Biology
2010
University of Milan
2004
Ospedale Garibaldi
1991-2004
University of Catania
1994-2004
University of Bologna
2002
We report a PCR-based technique for detecting thyroid cancer metastases in small nodes <1.5 cm diameter by the amplification of specific transcripts TSH-receptor and thyroglobulin. A 100% correspondence with histopathological diagnosis was observed 41/46 (89%) which an adequate sample obtained at fine needle aspiration. The genetic analysis that resulted more sensitive accurate than both cytological (28% inadequate samples, 17% false negative diagnoses) thyroglobulin measurement aspirates...
pancreatic adenocarcinoma is the fourth leading cause of cancer related deaths due to its aggressive behavior and poor clinical outcome. There a considerable variability in frequency serum tumor markers cancer' patients. We performed metabolomics screening patients diagnosed with cancer.Two targeted metabolomic assays were conducted on 40 samples healthy controls. Multivariate methods classification trees performed.Sparse partial least squares discriminant analysis (SPLS-DA) was used reduce...
Schwannomas are tumors that rarely involve the sinonasal tract or pterygopalatinefossa. Three cases of benign schwannomas originating in nasal cavity, nasal-ethmoid, and pterygopalatine fossa reported. Surgical treatment is considered choice to achieve long-term success. In this study, effectiveness endoscopic endonasal approach outlined for diagnosis these tumors.
Celiac disease (CD) is an autoimmune with the destruction of small intestinal villi, which occurs in genetically predisposed individuals. At present moment, a gluten-free diet (GFD) only way to restore functionality gut mucosa. However, there open debate on effects long-term supplementation through GFD, because some authors report unbalance microbial taxa composition. For microbiome analysis, fecal specimens were collected from 46 CD individuals GFD for at least 2 years and 30 healthy...
BACKGROUND Insulin receptor (IR), a member of the tyrosine kinase family, is expressed in normal thyroid cells and affects cell proliferation differentiation. METHODS The authors measured IR content benign malignant tumors by three independent methods: specific radioimmunoassay, 125I-insulin binding studies, immunohistochemistry. results obtained were compared with paired, adjacent, tissue. To assess function carcinoma cells, glucose uptake responsiveness to insulin was also studied human...
Thyroid nodules with a predominant follicular structure are often diagnosed as indeterminate at fine-needle aspiration biopsy (FNAB). We studied 453 patients thyroid nodule FNAB by using feed-forward artificial neural network (ANN) analysis to integrate cytologic and clinical data, the goal of subgrouping into high-risk in low-risk category. Three hundred seventy-one were used train 82 validate model. The smears blindly reviewed classified subgroup on basis standard criteria. Neural...
The aim of this study was to evaluate the prevention recurrent deep vein thrombosis (RDVT) with an oral antithrombotic agent (sulodexide) in moderate high-risk subjects. A group 405 patients included into multicenter registry. Both compression and exercise program were used as well a risk-factors control plan. After diagnosis DVT, treated anticoagulants for 6 months. At end period coagulation made started treatment sulodexide capsules 24 femoral, popliteal, tibial, superficial veins scanned...
In a previous study we demonstrated that 1-yr treatment with
Summary Long‐term outcome of patients with chronic hepatitis B virus ( HBV ) infection under continuous nucleos(t)ide analogues NUC s) has been poorly elucidated. We enrolled 121 anti‐ HB e‐positive into a prospective surveillance programme while on (>36 months) s therapy. ‐ DNA clearance, add‐on therapy and safety were evaluated. Development cirrhosis, events liver decompensation hepatocellular carcinoma HCC during the follow‐up main endpoints, as complication‐free survival. At baseline,...
The receptor for hepatocyte growth factor (Met) is not expressed in the normal thyroid but it overexpressed most carcinomas. We evaluated whether Met immunostaining of cytological smears from fine-needle aspiration biopsy (FNAB) may be useful preoperative diagnosis cancer. Notably, routine examination often fails to distinguish well-differentiated follicular carcinomas and a proportion papillary (low-grade variant [FVPTC]) benign lesions: all these lesions are usually classified as...
The effectiveness of a 12-week course sofosbuvir-ledipasvir in treatment-experienced HCV genotype 1b-infected patients with cirrhosis is still under debate. Our primary endpoint was to compare the sustained virological response at post-treatment week 12 (SVR12) combination ribavirin for weeks, and alone 24 weeks. This prospective observational study that enrolled 424 (195 naive, 229 experienced; 164 treated weeks Ribavirin 260 weeks) consecutive cirrhosis. SVR12 rates were 93.9% 99.2%...
Adriano Pellicelli, Vincenzo Messina, Valerio Giannelli1, Marco Distefano, Valeria Pace Palitti, Pascal Vignally, Pierluigi Tarquini, Antonio Izzi, Alessandra Moretti, Sergio Babudieri, Serena Dell’Isola, Massimo Marignani, Gaetano Scifo, Iovinella, Giuseppe Cariti, Maurizio Pompili, Francesco Di Candilo, Luca Fontanella, M. Ettorre, Giovanni Vennarecci, Ippolito, and Giorgio Barbarini, for the Working Group CLEO. Gut Liver 2020;14:357-67. https://doi.org/10.5009/gnl18269