A5010947074- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Neuroethics, Human Enhancement, Biomedical Innovations
- Biological Research and Disease Studies
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Histone Deacetylase Inhibitors Research
- PI3K/AKT/mTOR signaling in cancer
- Melanoma and MAPK Pathways
- Bioactive Compounds in Plants
- Hops Chemistry and Applications
- Genetics and Neurodevelopmental Disorders
- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- Nutrition, Genetics, and Disease
- CAR-T cell therapy research
- FOXO transcription factor regulation
- Science, Research, and Medicine
- Thyroid Cancer Diagnosis and Treatment
University of Palermo
2021-2024
Abstract Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. The cell subpopulation in lineage hierarchy that serves as origin for different TC histotypes unknown. Human embryonic stem cells (hESCs) with appropriate vitro stimulation undergo sequential differentiation into thyroid progenitor (TPCs-day 22), which maturate thyrocytes (day 30). Here, we create follicular cell-derived TCs all based on specific genomic alterations delivered by CRISPR-Cas9 hESC-derived TPCs....
Limited therapeutic options are available for advanced colorectal cancer (CRC). Herein, we report that exposure to a neo-synthetic bis(indolyl)thiazole alkaloid analog, nortopsentin 234 (NORA234), leads an initial reduction of proliferative and clonogenic potential CRC sphere cells (CR-CSphCs), followed by adaptive response selecting the CR-CSphC-resistant compartment. Cells spared treatment with NORA234 express high levels CD44v6, associated constitutive activation Wnt pathway. In...
Colorectal cancer (CRC) mortality is mainly caused by patient refractoriness to common anti-cancer therapies and consequent metastasis formation. Besides, the notorious toxic side effects of chemotherapy are a concurrent obstacle be tackled. Thus, new treatment approaches needed effectively improve outcomes. Compelling evidence demonstrated that stem cells (CSCs) responsible for failure relapse. New natural showed capabilities selectively target CSC subpopulation rendering them targetable...
Despite advances in the curative approach, survival rate of advanced colorectal cancer (CRC) patients is still poor, which likely due to emergence cell clones resistant available therapeutic options. We have already shown that CD44v6-positive CRC stem cells (CR-CSCs) are refractory toward standard anti-tumor agents activation PI3K pathway together with high HER2 expression levels. Tumor microenvironmental cytokines confer resistance CR-CSCs against HER2/PI3K targeting by enhancing MAPK...
Abstract Thyroid cancer (CT) is the most common endocrine organs malignancy and classified into:well-differentiated carcinomas, characterized by favourable prognosis sensitive to standardtreatments, undifferentiated carcinomas (UTC), lethal highly refractoryagainst current therapies. UTCs have invasive metastatic phenotype. The metastaticcascade model described distant metastasis origin deriving from cells that seed lymphnode then disseminate organs. According this, lymphadenectomy was...