A5047535840- Synthesis and biological activity
- Antimicrobial Peptides and Activities
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Click Chemistry and Applications
- Cancer therapeutics and mechanisms
- Advanced Breast Cancer Therapies
- Cancer-related Molecular Pathways
- Bacterial biofilms and quorum sensing
- Synthesis and Characterization of Heterocyclic Compounds
- Biochemical and Molecular Research
- Cancer-related gene regulation
- Bioactive Compounds and Antitumor Agents
- Hops Chemistry and Applications
- Antibiotic Resistance in Bacteria
- Phagocytosis and Immune Regulation
- Microbial Natural Products and Biosynthesis
- PI3K/AKT/mTOR signaling in cancer
- Extracellular vesicles in disease
- Synthesis and Biological Evaluation
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Bioactive Compounds in Plants
University of Palermo
2019-2025
Hospital Provincial de Rosario
2021-2022
Amsterdam UMC Location Vrije Universiteit Amsterdam
2018-2021
National University of Rosario
2021
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2021
University of Rome Tor Vergata
2007
Amherst College
1981
Emory University
1981
Johns Hopkins University
1981
University of Washington
1981
This paper is concerned with the control of glycolysis in nongrowing Stregtococcus lactis 7962.Changes were measured concentrations glycolytic intermediates, intracellular inorganic phosphate (Pi), and adenine nucleotides following addition glucose to cells that a starved condition.We find Pi major factor glycolysis.In cells, concentration high, greater than 40 nm.The large phosphoenolpyruvate pool exists can be explained as result inhibition pyruvate kinase by high Pi.On other hand, are...
Infectious diseases caused by antimicrobial-resistant strains have become a serious threat to global health, with high social and economic impact. Multi-resistant bacteria exhibit various mechanisms at both the cellular microbial community levels. Among different strategies proposed fight antibiotic resistance, we reckon that inhibition of bacterial adhesion host surfaces represents one most valid approaches, since it hampers virulence without affecting cell viability. Many structures...
Pyruvate dehydrogenase kinases (PDKs) are serine/threonine kinases, that directly involved in altered cancer cell metabolism, resulting aggressiveness and resistance. Dichloroacetic acid (DCA) is the first PDK inhibitor has entered phase II clinical; however, several side effects associated with weak anticancer activity excessive drug dose (100 mg/kg) have led to its limitation clinical application. Building upon a molecular hybridization approach, small library of 3-amino-1,2,4-triazine...
A new series of nortopsentin analogs, in which the central imidazole ring natural lead was replaced by a 1,3,4-oxadiazole or 1,3,4-thiadiazole moiety, efficiently synthesized. The antiproliferative activity all synthesized derivatives evaluated against five pancreatic ductal adenocarcinoma (PDAC) cell lines, primary culture and gemcitabine-resistant variant. more potent compounds elicited EC50 values submicromolar-micromolar range, associated with significant reduction migration. Moreover,...
Pancreatic ductal adenocarcinoma (PDAC) is one of the main aggressive types cancer, characterized by late prognosis and drug resistance. Among factors sustaining PDAC progression, alteration cell metabolism has emerged to have a key role in proliferation, invasion, resistance standard chemotherapeutic agents. Taking into account all these urgency evaluating novel options treat PDAC, present work we reported synthesis new series indolyl-7-azaindolyl triazine compounds inspired marine...
A new series of imidazo[2,1-b][1,3,4]thiadiazole derivatives was efficiently synthesized and screened for their in vitro antiproliferative activity on a panel pancreatic ductal adenocarcinoma (PDAC) cells, including SUIT-2, Capan-1 Panc-1. Compounds 9c 9l, showed relevant all three pre-clinical models with half maximal inhibitory concentration (IC50) ranging from 5.11 to 10.8 µM, while the compounds 9e 9n were active at least one cell line. In addition, compound significantly inhibited...
Abstract A new series of topsentin analogs, in which the central imidazole ring natural lead was replaced by a 1,2,4‐oxadiazole moiety, efficiently synthesized. All derivatives were pre‐screened for antiproliferative activity against National Cancer Institute (NCI‐60) cell lines panel. The five most potent compounds further investigated various pancreatic ductal adenocarcinoma (PDAC) lines, including SUIT‐2, Capan‐1, and Panc‐1 cells, eliciting EC 50 values micromolar sub‐micromolar range,...
Limited therapeutic options are available for advanced colorectal cancer (CRC). Herein, we report that exposure to a neo-synthetic bis(indolyl)thiazole alkaloid analog, nortopsentin 234 (NORA234), leads an initial reduction of proliferative and clonogenic potential CRC sphere cells (CR-CSphCs), followed by adaptive response selecting the CR-CSphC-resistant compartment. Cells spared treatment with NORA234 express high levels CD44v6, associated constitutive activation Wnt pathway. In...
Colorectal cancer (CRC) mortality is mainly caused by patient refractoriness to common anti-cancer therapies and consequent metastasis formation. Besides, the notorious toxic side effects of chemotherapy are a concurrent obstacle be tackled. Thus, new treatment approaches needed effectively improve outcomes. Compelling evidence demonstrated that stem cells (CSCs) responsible for failure relapse. New natural showed capabilities selectively target CSC subpopulation rendering them targetable...
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal form of cancer characterized by drug resistance, urging new therapeutic strategies. In recent years, protein kinases have emerged as promising pharmacological targets for the treatment several solid and hematological tumors. Interestingly, cyclin-dependent kinase 1 (CDK1) overexpressed in PDAC tissues has been correlated to aggressive nature these tumors because its key role cell cycle progression resistance induction apoptosis. For...
Pancreatic ductal adenocarcinoma (PDAC) is among the leading causes of cancer-related deaths worldwide. Focal adhesion kinase (FAK) a nonreceptor tyrosine often overexpressed in PDAC. FAK has been linked to cell migration, survival, proliferation, angiogenesis and adhesion. This review first highlights chemoresistant nature Second, role PDAC cancer progression resistance carefully described. Additionally, it discusses recent developments inhibitors as valuable drugs treatment PDAC, with...
Anti-virulence strategy is currently considered a promising approach to overcome the global threat of antibiotic resistance. Among different bacterial virulence factors, biofilm formation recognized as one most relevant. Considering high and growing percentage multi-drug resistant infections that are biofilm-mediated, new therapeutic agents capable counteracting biofilms urgently required. In this scenario, series 18 thiazole derivatives was efficiently synthesized evaluated for its ability...
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive tumor characterized by early invasiveness, rapid progression and resistance to treatment. For more than twenty years, gemcitabine has been the main therapy for PDAC both in palliative adjuvant setting. After introduction of FOLFIRINOX as upfront treatment metastatic disease, still commonly used combination with nab-paclitaxel alternative first-line regimen, well a monotherapy elderly patients unfit chemotherapy. As...