A5101820162- Allergic Rhinitis and Sensitization
- Glioma Diagnosis and Treatment
- Asthma and respiratory diseases
- Sinusitis and nasal conditions
- Nanoparticle-Based Drug Delivery
- Blood properties and coagulation
- Synthesis and biological activity
- Synthesis and Biological Activity
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Adipokines, Inflammation, and Metabolic Diseases
- Congenital Heart Disease Studies
- Hemophilia Treatment and Research
- Natural product bioactivities and synthesis
- Cancer, Lipids, and Metabolism
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Metal complexes synthesis and properties
- Sesquiterpenes and Asteraceae Studies
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Biopolymer Synthesis and Applications
- MicroRNA in disease regulation
- Blood Coagulation and Thrombosis Mechanisms
- Advanced Neuroimaging Techniques and Applications
Amsterdam University Medical Centers
2022-2025
Vrije Universiteit Amsterdam
2024-2025
Capital Medical University
2015-2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2023-2024
Cancer Center Amsterdam
2022-2024
Nanjing Maternity and Child Health Care Hospital
2024
Nanjing Medical University
2024
Tianjin University
2023
Tianjin Chest Hospital
2023
Sun Yat-sen Memorial Hospital
2022
Glioblastoma is the most common primary brain malignancy with limited treatment options. EphA2 a tumor-associated-antigen overexpressed in glioblastoma. Pre-clinical studies have demonstrated promise of EphA2-redirected CAR T-cells against We conduct first-in-human trial patients EphA2-positive recurrent glioblastoma and report results three enrolled as first cohort receiving starting dosage (1×106 cells/kg). A single infusion was administrated intravenously, lymphodepletion regimen...
A new series of nortopsentin analogs, in which the central imidazole ring natural lead was replaced by a 1,3,4-oxadiazole or 1,3,4-thiadiazole moiety, efficiently synthesized. The antiproliferative activity all synthesized derivatives evaluated against five pancreatic ductal adenocarcinoma (PDAC) cell lines, primary culture and gemcitabine-resistant variant. more potent compounds elicited EC50 values submicromolar-micromolar range, associated with significant reduction migration. Moreover,...
Gliomas are the most common type of primary brain tumor. Using current standard treatment regimens, prognosis patients with gliomas remains poor, which is predominantly due to resistance glioma cells chemotherapy. The organ microenvironment has been implicated in pathogenesis and survival tumor cells. Thus, aim present study was test hypothesis that astrocytes (the housekeeping microenvironment) may protect from chemotherapy investigate underlying mechanism. Immunofluorescent scanning...
Abstract Background Studies have found that circular RNAs (circRNAs) play key roles in cardiovascular diseases. However, the function of circROBO2 acute myocardial infarction (AMI) is unclear. This study aimed to investigate pathogenesis AMI. Methods qRT-PCR and Western blot were used determine expression levels circROBO2, miR-1184, TRADD AMI sham-operated mouse models at mRNA protein level, respectively. The relationship among was evaluated by RNA immunoprecipitation (RIP) analysis...
<i>Objective:</i> The mechanism of action involved in how <i>Dermatophagoides pteronyssinus</i> (Der p) 1 initiates the nasal allergic cascade is poorly understood. <i>Methods:</i> We detected proinflammatory cytokine production (GM-CSF, TNF-α, IL-1β, IL-6, and IL-8) associated signal molecules primarily cultured epithelial cells (NECs) from patients with rhinitis (AR) after Der p1 stimulation, using ELISA, RT-PCR, Western blot. also evaluated importance...
Focal Adhesion Kinase (FAK) is a non-receptor protein tyrosine kinase that plays crucial role in various oncogenic processes related to cell adhesion, migration, proliferation, and survival. The strategic targeting of FAK represents burgeoning approach address resistant tumours, such as pancreatic ductal adenocarcinoma (PDAC). Herein, we report new series twenty imidazo[2,1-
A detailed and exhaustive structural analysis by low-energy electron diffraction (LEED) is reported for the C${}_{60}$-induced reconstruction of Cu(111), in system Cu(111) $+$ (4 $\ifmmode\times\else\texttimes\fi{}$ 4)-C${}_{60}$. wide LEED energy range allows enhanced sensitivity to crucial C${}_{60}$-metal interface that buried below 7-\AA{}-thick molecular layer. The clearly favors a seven-Cu-atom vacancy model (with Pendry R-factor ${R}_{p}$ $=$ 0.376) over one-Cu-atom (${R}_{p}$ 0.608)...
Monoclonal antibodies (ICI) targeting the immune checkpoint PD-1/PD-L1 alone or in combination with chemotherapy have demonstrated relevant benefits and established new standards of care first-line treatment for advanced non-oncogene addicted non-small cell lung cancer (NSCLC). However, a percentage NSCLC patients, even high PD-L1 expression, did not respond to ICI, highlighting presence intracellular resistance mechanisms that could be dependent on levels. The signaling induced by tumor...
Erythropoietin (EPO) is a hematopoietic hormone that protects against renal interstitial fibrosis in animal models; however, the mechanism underlying anti‑fibrotic activity of EPO has remained elusive. The present study aimed to elucidate this mechanism. Twenty‑four male C57BL6 mice were randomly divided into four groups, each comprising six mice: (i) control group (Sh); (ii) unilateral ureteral obstruction (UUO) plus vehicle (U+V); (ⅲ) UUO 300 U/kg body weight recombinant human (rh)EPO...
Aluminum-maltolate (Al‑Malt) is a potent apoptosis inductor, which has been widely reported as an etiologic factor in Alzheimer's disease (AD). MicroRNA-322 (miR‑322) vital regulator various biological processes. The aim of the current study was to identify role and possible underlying mechanism miR‑322 Al‑Malt‑induced apoptosis. Eight concentrations Al‑Malt were prepared used for treating human neuroblastoma cell line, SH‑SY5Y. Subsequent treatment with 3 days, viability, expression levels...
Abstract The design of smart targeted drug delivery systems that deliver drugs to specific cancer cells will give rise treatments with better efficacy and lower toxicity levels. We report the development characterizations maleimide‐functionalized biopolymer (Mal‐PGA‐Asp) as an effective carrier synthesized from amidation reaction between aspartylated PGA (PGA‐Asp) N ‐(maleimidohexanoyl)‐ethylenediamine (NME). epidermal growth factor receptor (EGFR) targeting peptide (TP13) was conjugated...
Specific immunotherapy (SIT) is a suitable but uncommon treatment option for allergic rhinitis (AR) in China. The current understanding and attitude of Chinese ENT (ear, nose, throat) specialists regards to SIT unclear. This study investigates trends the awareness application status among specialists. We performed nationwide, cross-sectional survey with specially designed questionnaire given 800 A member trained research group conducted face-to-face interviews each respondent. Most...
Poly(γ-glutamic acid)-based targeted drug delivery system (PAMCN) targeting transmembrane metalloprotease aminopeptidase-N (APN/CD13) was fabricated and evaluated for the enhancement of efficiency cytotoxicity. The cisplatin (CDDP) loading content PAMCN about 36 ± 5% showed a sustainable release profile with half-maximal time (t1/2) 23 h. average size 132 18 nm determined by light scattering (LS) 158 67 atomic force microscopy (AFM). Flow cytometry fluorescence microscope analysis that...
Gliomas exhibit high intra-tumoral histological and molecular heterogeneity. Introducing stereotactic biopsy, we achieved a superior analysis of glioma using O-(2-18F-fluoroethyl)-L-tyrosine (FET)-positron emission tomography (PET) diffusion-weighted magnetic resonance imaging (DWI). Patients underwent simultaneous DWI FET-PET scans. Correlations between biopsy-derived tumor tissue values, such as the tumor-to-background ratio (TBR) apparent diffusion coefficient (ADC)/exponential ADC (eADC)...