A5048773551- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Retinal Diseases and Treatments
- Liver Disease and Transplantation
- Retinal Imaging and Analysis
- Infective Endocarditis Diagnosis and Management
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Antibiotic Resistance in Bacteria
- Metabolism, Diabetes, and Cancer
- Antimicrobial Resistance in Staphylococcus
- Cardiovascular Function and Risk Factors
- Sepsis Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 and healthcare impacts
- Adipokines, Inflammation, and Metabolic Diseases
- Venous Thromboembolism Diagnosis and Management
- Endometriosis Research and Treatment
- Ophthalmology and Eye Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Glaucoma and retinal disorders
- Cardiovascular Disease and Adiposity
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
Agostino Gemelli University Polyclinic
2022-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2022-2024
University of Campania "Luigi Vanvitelli"
2017-2023
University of Molise
2023
Science & Technology Park (Czechia)
2023
University of Naples Federico II
2016-2020
Ospedale Monaldi
2016-2018
Multiple modifiable risk factors for late complications in patients with diabetic kidney disease (DKD), including hyperglycemia, hypertension and dyslipidemia, increase the of a poor outcome. DKD is associated very high cardiovascular risk, which requires simultaneous treatment these by implementing an intensified multifactorial approach. However, efficacy intervention on major fatal/non-fatal events (MACEs) has been poorly investigated.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated significant morbidity and reduced health-related quality of life. Findings from clinical trials have demonstrated the effectiveness dupilumab in CRSwNP, although real-world evidence still limited.This Phase IV real-life, observational, multicenter study assessed safety patients severe uncontrolled CRSwNP (n = 648) over first year treatment. We collected data at baseline after 1, 3, 6, 9, 12 months follow-up. focused on score...
Abstract Background We evaluated the association between mortality and colistin resistance in Acinetobacter baumannii infections interaction with antibiotic therapy. Methods This is a secondary analysis of randomized controlled trial patients carbapenem-resistant gram-negative bacterial treated or colistin-meropenem combination. infection caused by A. (CRAB) identified as susceptible (CoS) at time treatment compared which isolate was confirmed CoS those whose isolates were retrospectively...
In patients with Normal Glucose Tolerance (NGT) some causes of ischemic heart disease (IHD) were not completely investigated. The role both metabolic milieu and adipokines in IHD progression was fully Our aim to assess the link between plasma levels, insulin resistance (IR) NGT undergoing Percutaneous Coronary Intervention (PCI). AIRE is a single-center prospective longitudinal observational study investigating outcome subjects who underwent coronary revascularization by PCI third level...
Non-Alcoholic Fatty Liver Disease (NAFLD) is caused by the accumulation of fat in over 5% hepatocytes absence alcohol consumption. NAFLD considered hepatic manifestation metabolic syndrome (MS). Recently, an expert consensus suggested as more appropriate term MAFLD (metabolic-associated fatty liver disease). Insulin resistance (IR) plays a key role development NAFLD, it causes increase lipogenesis and inhibition adipose tissue lipolysis. Beyond imbalance adipokine levels, mass visceral also...
Abstract Purpose SARS-COV-2 pandemic led to antibiotic overprescription and unprecedented stress on healthcare systems worldwide. Knowing the comparative incident risk of bloodstream infection due multidrug-resistant pathogens in COVID ordinary wards intensive care-units may give insights into impact COVID-19 antimicrobial resistance. Methods Single-center observational data extracted from a computerized dataset were used identify all patients who underwent blood cultures January 1, 2018 May...
To assess the effect of hepatitis C virus (HCV) eradication on type 2 diabetes mellitus (T2DM). incidence.A prospective multicentre case-control study was performed, which included 2426 patients with HCV, 42% whom had liver fibrosis stage F0-F2 and 58% F3-F4. The population consisted a control group including 1099 untreated 1327 cases treated direct-acting antivirals (DAAs). T2DM incidence assessed during median (interquartile range) follow-up period 30 (28-42) months. Risk factors for were...
Abstract Aims Diabetic retinopathy (DR) represents the main cause of blindness among adults in industrialized Countries. Use telemedicine could offer an easy, smart specialist fundus oculi examination, as well putting a screening programme many patients who otherwise would be excluded. Materials and methods The NO BLIND is transversal, multicentre, observational study. Its pilot phase involved nine public outpatient clinics for 6 months. As endpoint study, we assessed prevalence DR by...
An unexpected increased HCC recurrence and occurrence rate among HCV patients treated with direct acting antivirals combination has been reported. Aim of the study was evaluation early its risk factors in a infected population, direct-acting-antivirals. According to Italian ministerial guidelines for direct-acting-antivirals treatment, 1022 consecutive were enrolled. Patients either active at imaging or history previous HCC, HBV HIV co-infection, liver transplant recipients excluded. The...
The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex only partially known. purpose of this paper was to review current knowledge these in a unified manner. Subjects with NAFLD T2DM have established insulin resistance (IR), which exacerbates two comorbidities. IR worsens by increasing accumulation free acids (FFAs) liver. This occurs due an increase influx FFAs from...
Most recent studies have stressed a high risk of thromboembolism in patients with SARS-CoV-2 infection, particularly those severe COVID-19 pneumonia. Counterbalance between angiotensin-converting-enzyme (ACE) and ACE2 activities disease may be crucially involved the thrombo-inflammatory process. Currently, no study has investigated ACE I/D polymorphism involvement complicated by pulmonary embolism, hence aim present pilot study. This is retrospective, single-center observational case-control...