Oren Zusman
A5006273555- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Pneumonia and Respiratory Infections
- Clinical Nutrition and Gastroenterology
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Antibiotic Use and Resistance
- Venous Thromboembolism Diagnosis and Management
- Coronary Interventions and Diagnostics
- Nutrition and Health in Aging
- Heart Failure Treatment and Management
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Sepsis Diagnosis and Treatment
- Urinary Tract Infections Management
- Bacterial Identification and Susceptibility Testing
- Health Systems, Economic Evaluations, Quality of Life
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
Rabin Medical Center
2013-2024
Tel Aviv University
2014-2024
Carmel Medical Center
2019
Tel Aviv Sourasky Medical Center
2017
Ben-Gurion University of the Negev
2011
Intense debate exists regarding the optimal energy and protein intake for intensive care unit (ICU) patients. However, most studies use predictive equations, demonstrated to be inaccurate target intake. We sought examine outcome of a large cohort ICU patients in relation percent administered calories divided by resting expenditure (% AdCal/REE) obtained indirect calorimetry (IC) Included were hospitalized from 2003 2015 at 16-bed university affiliated, tertiary hospital, had IC measurement...
Abstract Background We evaluated the association between mortality and colistin resistance in Acinetobacter baumannii infections interaction with antibiotic therapy. Methods This is a secondary analysis of randomized controlled trial patients carbapenem-resistant gram-negative bacterial treated or colistin-meropenem combination. infection caused by A. (CRAB) identified as susceptible (CoS) at time treatment compared which isolate was confirmed CoS those whose isolates were retrospectively...
It is currently uncertain whether early administration of protein improves patient outcomes. We examined mortality rates critically ill patients receiving compared to late administration. This was a retrospective cohort study mixed ICU enteral or parenteral nutritional support. Patients >0.7 g/kg/d within the first 3 days were considered group and those less group. The latter subdivided into late-low (LL) who received low intake (<0.7 g/kg/d) throughout their stay late-high (LH) higher...
Optimizing colistin dosing should translate to improved patient outcomes. We used data from 2 prospective cohort studies performed between 2006 and 2009 2012 2015. In the latter period, a new policy of high-dose (9 million international units [MIU] loading dose followed by 9 MIU daily for normal renal function) was introduced in participating hospitals. included adult inpatients with invasive infections caused carbapenem-resistant gram-negative bacteria treated colistin. Our primary exposure...
Colistin heteroresistance (HR) refers to a bacterial population comprised of several subpopulations with different levels resistance colistin. In this study, we discuss the classic form HR, in which resistant subpopulation exists within predominantly susceptible population. We investigated prevalence colistin HR and its evolution into full among 173 clinical carbapenem-resistant Acinetobacter baumannii isolates examined effect on outcomes. To determine performed analysis profiling. Our...
The emergence of antibiotic-resistant bacteria has driven renewed interest in older antibacterials, including colistin. Previous studies have shown that colistin is less effective and more toxic than modern antibiotics. In vitro synergy clinical observational suggest a benefit combining with carbapenem. A randomised controlled study necessary for clarification. This multicentre, investigator-initiated, open-label, superiority 1:1 comparing monotherapy colistin-meropenem combination therapy...
Catheter associated urinary tract infection (CAUTI) is the most common healthcare-associated acquired infection. We aimed to describe short- and long-term survival of patients with CAUTI impact empirical antibiotic treatment on rates.In this prospective observational study we included consecutive adult a chronic indwelling catheter-associated UTI sepsis hospitalized in medical departments. The primary outcomes were 30-days all-cause mortality at end follow-up. A multivariate analysis using...
Abstract Background Empirical colistin should be avoided. We aimed to evaluate the association between covering empirical antibiotics (EAT) and mortality for infections caused by carbapenem-resistant gram-negative bacteria (CRGNB). Methods This was a secondary analysis of randomized controlled trial, including adults with bloodstream infections, pneumonia, or urosepsis CRGNB. All patients received EAT followed targeted therapy. The exposure variable in first 48 hours. outcome 28-day...
Indirect calorimetry (IC) measurement is considered the gold standard for assessment of resting energy expenditure (REE). It based on oxygen and carbon dioxide consumption (VO
Therapeutic options available to treat MRSA pneumonia are limited. Trimethoprim/sulfamethoxazole is an attractive treatment because of its bactericidal anti-MRSA activity, oral and parenteral formulations good penetration the lung tissue. We aimed compare efficacy safety trimethoprim/sulfamethoxazole with vancomycin in healthcare/ventilator-associated pneumonia.We carried out a retrospective case-control study all consecutive hospitalized adult patients diagnosed at Beilinson Hospital during...
We evaluated whether carbapenem-colistin combination therapy reduces the emergence of colistin resistance, compared to monotherapy, when given patients with infections due carbapenem-resistant Gram-negative organisms.This is a pre-planned analysis secondary outcome from randomized, controlled trial comparing monotherapy colistin-meropenem for treatment severe caused by carbapenem-resistant, colistin-susceptible bacteria. rectal swabs taken on Day 7 or later presence new colistin-resistant...
Abstract Objectives To describe the population genetics and antibiotic resistance gene distribution of carbapenem-resistant Acinetobacter baumannii (CRAB) isolates causing infections in three Mediterranean countries. Methods Isolates were collected during 2013–17 AIDA clinical trial six hospitals Israel, Greece Italy. WGS, bioinformatic characterization profiling performed. Results In 247 CRAB characterized this study, ST varied by country: 29/31 (93.5%) Greek isolates, 34/41 (82.9%) Italian...