A5071649135- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Parathyroid Disorders and Treatments
- Pneumonia and Respiratory Infections
- Genetic Syndromes and Imprinting
- Neuroendocrine Tumor Research Advances
- Thyroid and Parathyroid Surgery
- Bone health and osteoporosis research
- Bone health and treatments
- Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Vitamin D Research Studies
- Urban Stormwater Management Solutions
- Neutropenia and Cancer Infections
- Land Use and Ecosystem Services
- Pancreatic and Hepatic Oncology Research
- Social and Educational Sciences
- Abdominal Surgery and Complications
- Pharmacogenetics and Drug Metabolism
- Hernia repair and management
- Pituitary Gland Disorders and Treatments
- Public Policy and Administration Research
- Public-Private Partnership Projects
- Muscle metabolism and nutrition
- Environmental Conservation and Management
Uppsala University
2015-2024
Swedish University of Agricultural Sciences
2017-2019
Linköping University
2019
Uppsala University Hospital
1992-2018
Lasarettet i Motala
2018
Aalborg University
2016
Umeå University
1986-2010
University Hospital of Umeå
1987-2004
AstraZeneca (Sweden)
1976
Objectives Off-label use of rituximab to treat MS patients in Sweden is high, and the need for long-term safety data may not be met. Our objectives were assess rate prescription with multiple sclerosis and, addition, evaluate a single centre sclerosis. Material Methods Review Swedish register was performed study number treated during last 6 years. Investigation also included retrospective review medical files search possible side effects/adverse events all adult at Uppsala University...
The emergence of antibiotic-resistant bacteria has driven renewed interest in older antibacterials, including colistin. Previous studies have shown that colistin is less effective and more toxic than modern antibiotics. In vitro synergy clinical observational suggest a benefit combining with carbapenem. A randomised controlled study necessary for clarification. This multicentre, investigator-initiated, open-label, superiority 1:1 comparing monotherapy colistin-meropenem combination therapy...
Combination therapy can be a strategy to ensure effective bacterial killing when treating Pseudomonas aeruginosa, Gram-negative bacterium with high potential for developing resistance. The aim of this study was develop pharmacokinetic/pharmacodynamic (PK/PD) model that describes the in vitro time–kill curves colistin and meropenem alone combination one WT meropenem-resistant strain P. aeruginosa. In curve experiments were conducted aeruginosa (ATCC 27853) (MICs: 1 mg/L; mg/L) type (ARU552)...
Physical activity is most probably an important factor to increase bone mass. The exact mechanisms by which this takes place are not completely understood. During the last years methods have become available making it possible study metabolism of type I collagen in more detail. In seven male athletes were studied before and after a short-term maximal work (a modified Wingate test at retardation 7.5 % body weight) during 30 seconds. Blood samples drawn 5 60 minutes after. Serum concentrations...
Fatigue and muscular weakness are prevalent symptoms in patients with primary hyperparathyroidism. This study examined strength before after operation a group of eight hyperparathyroidism control seven benign thyroid lesions. The maximum power grip, pronation supination, endurance for the same movements, were studied by means computer program. Patients had impaired compared controls but 12 months significant improvement all performance was observed. No such detectable among controls. There...
Abstract A randomized study of the value drainage in thyroid and parathyroid surgery is presented. Fifty patients were provided with surgical drains another fifty allocated to a control group without drainage. Complications few either rate subjective discomfort from collar incision was equally low both groups. The observations suggest that provision not necessary after uncomplicated neck surgery.
ABSTRACT Sufficient antibiotic dosing in septic patients is essential for reducing mortality. Piperacillin-tazobactam often used empirical treatment, but due to the pharmacokinetic (PK) variability seen patients, optimal may be a challenge. We determined PK profile piperacillin given at 4 g every 8 h 22 admitted medical ward. Piperacillin concentrations were compared clinical breakpoint MIC Pseudomonas aeruginosa (16 mg/liter), and following PK/pharmacodynamic (PD) targets evaluated:...
ObjectivesThe aim was to analyse the population pharmacokinetics of colistin and explore relationship between exposure time death.MethodsPatients included in AIDA randomized controlled trial were treated with for severe infections caused by carbapenem-resistant Gram-negative bacteria. All subjects received a 9 million units (MU) loading dose, followed 4.5 MU twice daily maintenance dose reduction if creatinine clearance (CrCL) < 50 mL/min. Individual exposures estimated from developed...
Abstract Background Lithium therapy for affective bipolar disease is frequently associated with hyperparathyroidism (HPT), but the results of surgical treatment are virtually unknown. The aim this retrospective review was to analyse long-term outcome after surgery lithium-induced HPT in a large series patients. Methods Seventy-one patients on chronic lithium who underwent three university and district hospitals Sweden were followed median 6·3 years. Histopathology, complications...
Abstract BI 730357 is investigated as an oral treatment of plaque psoriasis. We analyzed the impact three dosage regimens on Psoriasis Area and Severity Index (PASI) response with modeling based phase I II data from 109 healthy subjects 274 patients moderate‐to‐severe The pharmacokinetics (PK) was characterized by a two‐compartment model dual absorption paths first‐order elimination. Higher baseline C‐reactive protein associated lower clearance generally had compared subjects. A bounded...
KRISTOFFERSSON, ANDERS; DAHLGREN, SVEN; LITHNER, FOLKE; JÄRHULT, JOHANNES Author Information
This paper argues that adopting a stakeholder approach to the study of contracting outcomes produces more rich and rounded representations realities out public services. We revisit research on outcomes, highlighting manager perspective as key for gaining deeper, detailed insights. The is explored in an inductive analysis answers open-ended survey questions collected from managers with experience within context municipal park management Scandinavia. emerging managerial summarized best-case,...