A5102720313- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Papaya Research and Applications
- Insect Pest Control Strategies
- Pneumonia and Respiratory Infections
- Andrographolide Research and Applications
- Nanoparticles: synthesis and applications
- Tuberculosis Research and Epidemiology
- Computational Drug Discovery Methods
- Neurological Disease Mechanisms and Treatments
- Diet and metabolism studies
- Trypanosoma species research and implications
- Infectious Encephalopathies and Encephalitis
- Ginger and Zingiberaceae research
- Microstructure and mechanical properties
- SARS-CoV-2 and COVID-19 Research
- Traditional Chinese Medicine Analysis
- GABA and Rice Research
- Parasites and Host Interactions
- Berberine and alkaloids research
- Medicinal Plants and Bioactive Compounds
- Cocoa and Sweet Potato Agronomy
- Cancer, Lipids, and Metabolism
- Inflammasome and immune disorders
- Phytochemical compounds biological activities
Institute for Medical Research
2014-2025
Ministry of Health
2019-2025
King Saud University
2024
Uppsala University
2011-2016
ABSTRACT A previous pharmacokinetic study on dosing of colistin methanesulfonate (CMS) at 240 mg (3 million units [MU]) every 8 h indicated that has a long half-life, resulting in insufficient concentrations for the first 12 to 48 after initiation treatment. loading dose would therefore be beneficial. The aim this was evaluate CMS and pharmacokinetics following 480-mg (6-MU) critically ill patients explore bacterial kill use different regimens obtained by predictions from...
Gentamicin is commonly used in the management of neonatal infections. Development adaptive resistance typical for aminoglycosides and reduces antibacterial effect. There is, however, a lack understanding how this phenomenon influences effect different dosing schedules. The aim was to develop pharmacokinetic-pharmacodynamic (PKPD) model that describes time course bactericidal activity gentamicin its investigate schedules preterm term newborn infants based on developed model. In vitro...
An optimized dosing regimen of the prodrug colistin, colistin methanesulphonate (CMS), against resistant Pseudomonas aeruginosa is needed to ensure effective bacterial killing. The objectives this study were develop a pharmacokinetic (PK)/pharmacodynamic (PD) model that characterizes time course antibacterial activity P. in static vitro system and perform simulations different regimens algorithms evaluate effect interindividual variability interoccasion PK on Static time–kill curve...
Combination therapy can be a strategy to ensure effective bacterial killing when treating Pseudomonas aeruginosa, Gram-negative bacterium with high potential for developing resistance. The aim of this study was develop pharmacokinetic/pharmacodynamic (PK/PD) model that describes the in vitro time–kill curves colistin and meropenem alone combination one WT meropenem-resistant strain P. aeruginosa. In curve experiments were conducted aeruginosa (ATCC 27853) (MICs: 1 mg/L; mg/L) type (ARU552)...
Carica papaya leaves have been used for traditional treatment of dengue fever and reported to exhibit an immunomodulatory activity by affecting the level cytokine production in vitro vivo. Due lack adequate vivo evidence disease model, present study was initiated screen identify cytokines affected freeze-dried C. leaf juice (FCPLJ) AG129 mice infected with DEN-2 virus.The were fed orally FCPLJ 3 consecutive days after 24 h virus inoculation. Plasma screened using ProcartaPlex immunoassay....
The role of Carica papaya L. leaf juice in immune dysregulation caused by dengue virus infection remains unclear. This study aimed to investigate the immunomodulatory activities freeze-dried C. (FCPLJ) on AG129 mice infected with a clinical DENV-2 (DMOF015) isolate. were orally treated 500 and 1000 mg/kg/day FCPLJ, for three days. Platelet, leukocyte, lymphocyte neutrophil counts microscopically determined. level plasma proinflammatory cytokines was measured multiplex immunoassay. levels...
This paper aims to examine the development processes and challenges of Malaysian Herbal Monographs (MHM) committees in developing herbal monograph. With increasing demand market, efforts were made under Agriculture National Key Economic Area identify high-value botanical drugs contribute transformation products towards nutraceuticals. The MHM established streamline process monograph with main activity assisting industrial sector their product preparations. publication consists selection,...
Eurycoma longifolia is one of the commonly consumed herbal preparations and its major chemical compound, eurycomanone, has been described to have antimalarial, antipyretic, aphrodisiac, cytotoxic activities. Today, consumption E. popular through incorporation extract in food items, most frequently drinks such as tea coffee. In current study, characterisation physicochemical pharmacokinetic (PK) attributes eurycomanone were conducted via a series vitro vivo studies rats mice. The solubility...
Carica papaya leaf juice (CPLJ) was well known for its thrombocytosis activity in rodents and dengue patients. However, the effect of CPLJ treatment on other parameters that could contribute to pathogenesis such as nonstructural protein 1 (NS1) production viremia level have never been highlighted any clinical vivo studies. The aim this study is investigate freeze-dried NS1 levels fever mouse model. infection model established by inoculation non-mouse adapted New Guinea C strain virus (DEN-2)...
The purpose of this study was to profile and identify the endothelial cell biology related genes that are affected by dengue virus infection in liver tissue AG129 mice, with without Carica papaya leaf juice treatment. fever mouse model established intraperitoneal inoculation virus, New Guinea C strain at 2 × 106 PFU. Daily oral administration 1000 mg/kg freeze-dried C. (FCPLJ) done starting from day 1 3 post infection. RNA extracted tissues harvested on 4 expression levels 84 were determined...
Chloroquine (CQ) and fansidar (sulphadoxine-pyrimethamine, SP) were widely used for treatment of Plasmodium falciparum several decades in Malaysia prior to the introduction Artemisinin-based Combination Therapy (ACT) 2008. Our previous study Kalabakan, located south-east coast Sabah showed a high prevalence resistance CQ SP, suggesting use may no longer be effective area. This aimed provide baseline data antimalarial drug resistant markers on P. isolates Kota Marudu north-east Sabah....
Since the COVID-19 pandemic in 2020, many reports have highlighted several potential anti-SARS-CoV-2 drug candidates, including phenolic compounds. Therefore, this study aimed to evaluate activity of nine common compounds found plants using vitro cellular infection model. The curcumin, quercetin, gallic acid, catechin, rutin, kaempferol, naringenin, coumaric acid and caffeic were evaluated on SARS-CoV-2-infected Vero E6 cells by a cytopathic effect (CPE)-based assay. human lung cells, A549...
In early 2020, COVID-19 pandemic has mobilized researchers in finding new remedies including repurposing of medicinal plant products focusing on direct-acting antiviral and host-directed therapies. this study, we performed an vitro investigation the standardized Marantodes pumilum extract (SKF7
3-Monochloropropane-1,2-diol esters (3-MCPDE) are food contaminants commonly found in refined vegetable oils and fats, which have possible carcinogenic implications humans. To investigate this clinically, we conducted an occurrence level analysis on eight categories of retail cooked consumed Malaysia. This was used to estimate the daily exposure level, through a questionnaire-based case-control study involving 77 subjects with renal cancer, 80 matching controls. Adjusted Odds Ratio (AOR)...
tralising antibodies by surrogate virus neutralization test (sVNT) and plaque reduction (PRNT).Findings: Among the 1,736 HCWs enrolled in our cohort, 252 provided pre-and post-vaccination blood samples after each dose of either vaccine.Two doses BNT162b2 generated levels neutralizing (sVNT inhibition = 96.8%,range 42.8%,98.2%) comparable to those natural infections first wave 84.0%,range 32.9%,93.8%).Similar were achieved with three CoronaVac 95.3%, range 64.7%,98.3%) heterologous...