Vered Daitch
A5011998661- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Long-Term Effects of COVID-19
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Antibiotic Use and Resistance
- Vibrio bacteria research studies
- Intensive Care Unit Cognitive Disorders
- Nosocomial Infections in ICU
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical and Antibiotic Environmental Impacts
- Plant Pathogenic Bacteria Studies
- COVID-19 diagnosis using AI
- Psychosomatic Disorders and Their Treatments
- Cystic Fibrosis Research Advances
- Antimicrobial Resistance in Staphylococcus
- Radiology practices and education
- Heart Failure Treatment and Management
- Meta-analysis and systematic reviews
- Tuberculosis Research and Epidemiology
- Child Nutrition and Feeding Issues
- Enterobacteriaceae and Cronobacter Research
Rabin Medical Center
2015-2024
Tel Aviv University
2014-2023
Misgav Ladach
2018
Abstract Background We evaluated the association between mortality and colistin resistance in Acinetobacter baumannii infections interaction with antibiotic therapy. Methods This is a secondary analysis of randomized controlled trial patients carbapenem-resistant gram-negative bacterial treated or colistin-meropenem combination. infection caused by A. (CRAB) identified as susceptible (CoS) at time treatment compared which isolate was confirmed CoS those whose isolates were retrospectively...
To describe long-COVID symptoms among older adults and to assess the risk factors for two common symptoms: fatigue dyspnea.This is a multicenter, prospective cohort study conducted in Israel, Switzerland, Spain, Italy. Individuals were included at least 30 days after their COVID-19 diagnosis. We compared between elderly (aged >65 years) younger individuals 18-65 univariate multivariable analyses predictors of dyspnea.A total 2333 evaluated an average 5 months (146 [95% confidence interval...
Abstract Background Fatigue is the most prevalent and debilitating long-COVID (coronavirus disease) symptom; however, risk factors pathophysiology of this condition remain unknown. We assessed for fatigue explored its possible pathophysiology. Methods This was a nested case-control study in COVID recovery clinic. Individuals with (cases) without (controls) significant were included. performed multidimensional assessment evaluating various parameters, including pulmonary function tests...
Optimizing colistin dosing should translate to improved patient outcomes. We used data from 2 prospective cohort studies performed between 2006 and 2009 2012 2015. In the latter period, a new policy of high-dose (9 million international units [MIU] loading dose followed by 9 MIU daily for normal renal function) was introduced in participating hospitals. included adult inpatients with invasive infections caused carbapenem-resistant gram-negative bacteria treated colistin. Our primary exposure...
Colistin heteroresistance (HR) refers to a bacterial population comprised of several subpopulations with different levels resistance colistin. In this study, we discuss the classic form HR, in which resistant subpopulation exists within predominantly susceptible population. We investigated prevalence colistin HR and its evolution into full among 173 clinical carbapenem-resistant Acinetobacter baumannii isolates examined effect on outcomes. To determine performed analysis profiling. Our...
Abstract Background Empirical colistin should be avoided. We aimed to evaluate the association between covering empirical antibiotics (EAT) and mortality for infections caused by carbapenem-resistant gram-negative bacteria (CRGNB). Methods This was a secondary analysis of randomized controlled trial, including adults with bloodstream infections, pneumonia, or urosepsis CRGNB. All patients received EAT followed targeted therapy. The exposure variable in first 48 hours. outcome 28-day...
ObjectivesThe aim was to analyse the population pharmacokinetics of colistin and explore relationship between exposure time death.MethodsPatients included in AIDA randomized controlled trial were treated with for severe infections caused by carbapenem-resistant Gram-negative bacteria. All subjects received a 9 million units (MU) loading dose, followed 4.5 MU twice daily maintenance dose reduction if creatinine clearance (CrCL) < 50 mL/min. Individual exposures estimated from developed...
We evaluated whether carbapenem-colistin combination therapy reduces the emergence of colistin resistance, compared to monotherapy, when given patients with infections due carbapenem-resistant Gram-negative organisms.This is a pre-planned analysis secondary outcome from randomized, controlled trial comparing monotherapy colistin-meropenem for treatment severe caused by carbapenem-resistant, colistin-susceptible bacteria. rectal swabs taken on Day 7 or later presence new colistin-resistant...
Abstract Objectives To describe the population genetics and antibiotic resistance gene distribution of carbapenem-resistant Acinetobacter baumannii (CRAB) isolates causing infections in three Mediterranean countries. Methods Isolates were collected during 2013–17 AIDA clinical trial six hospitals Israel, Greece Italy. WGS, bioinformatic characterization profiling performed. Results In 247 CRAB characterized this study, ST varied by country: 29/31 (93.5%) Greek isolates, 34/41 (82.9%) Italian...
Background. Traditional wisdom suggests that infections in older patients have atypical presentation, including blunted febrile response. Data are scarce.
Sepsis is associated with excessive release of catecholamines, which causes tachycardia and correlated poor clinical outcome. β-Blockers (BBs) may blunt this effect on heart rate (HR). The objective study to assess whether long-term BB therapy better outcomes in patients sepsis admitted internal medicine wards.We performed a single-center, observational cohort study. We included adult who were hospitalized departments due sepsis. A propensity score model for was used match patients. primary...
Abstract Background Population external validity is the extent to which an experimental study results can be generalized from a specific sample defined population. In order apply of study, we should able assess its population validity. We performed investigator-initiated randomized controlled trial (RCT) (AIDA study), compared colistin-meropenem combination therapy colistin monotherapy in treatment patients infected with carbapenem-resistant Gram-negative bacteria. examine study’s and...
Background: Venous thromboembolism (VTE) is a feared complication during hospitalization. The practice of administering pharmacological prophylaxis highly endorsed despite failure studies to show reduction in mortality.
The Combination Antibiotic Therapy for Methicillin-Resistant Staphylococcus aureus (CAMERA2) trial ceased recruitment in July 2018, noting that a higher proportion of patients the intervention arm (combination therapy) developed acute kidney injury (AKI) compared to standard therapy (monotherapy) arm. We analyzed long-term outcomes participants CAMERA2 understand impact combination antibiotic and AKI.Trial sites obtained additional follow-up data. primary outcome was all-cause mortality,...
Abstract Background Antimicrobial stewardship (AMS) programmes are established across the world to treat infections efficiently, prioritize patient safety, and reduce emergence of antimicrobial resistance. One core elements AMS is guidance support direct physicians in making efficient, safe optimal decisions when prescribing antibiotics. To optimize tailor AMS, we need a better understanding physicians’ experience with guidance. Objectives explore user experience, needs targeted improvements...