A5088809793- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Asthma and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral-associated cancers and disorders
- Respiratory and Cough-Related Research
- Hematopoietic Stem Cell Transplantation
- Respiratory Support and Mechanisms
- Cardiovascular Issues in Pregnancy
- Pregnancy and Medication Impact
- Mycobacterium research and diagnosis
- Sarcoidosis and Beryllium Toxicity Research
- Pregnancy-related medical research
- Anesthesia and Pain Management
- Eosinophilic Esophagitis
- Animal Virus Infections Studies
- Pediatric Pain Management Techniques
- Polyomavirus and related diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Pediatric health and respiratory diseases
Rabin Medical Center
2017-2024
Tel Aviv University
2018-2024
Cardio-Pulmonary Institute
2015
Ben-Gurion University of the Negev
2004-2007
Christie's
2007
Abstract Background Fatigue is the most prevalent and debilitating long-COVID (coronavirus disease) symptom; however, risk factors pathophysiology of this condition remain unknown. We assessed for fatigue explored its possible pathophysiology. Methods This was a nested case-control study in COVID recovery clinic. Individuals with (cases) without (controls) significant were included. performed multidimensional assessment evaluating various parameters, including pulmonary function tests...
Background The interleukin 5 (IL-5) pathway is an important component in the pathophysiology of severe eosinophilic asthma. Mepolizumab a monoclonal antibody that targets IL-5 pathway. Clinical trials showed efficacy patients with However, reports on experience treatment real-world cohort are limited.Objectives Evaluation and safety for asthma patients.Methods A clinical prospective observational trial included all >18 years treated between March 2016 to 2019 at Rabin Medical Center....
Patients with COVID-19 report severe respiratory symptoms consistent ARDS. The clinical presentation of ARDS in is often atypical, as patients exhibit a disproportionate hypoxemia compared relatively preserved lung mechanics. This pattern more similar to neonatal distress syndrome secondary surfactant deficiency, which has been shown benefit from exogenous surfactant. We present our experience treatment patient experiencing COVID-19-related responded improved oxygenation, and we believe was...
Cryptogenic organizing pneumonia (COP) is an interstitial lung disease that usually responsive to corticosteroid treatment. The treatment of COP has not been studied in randomized controlled trials; thus, decisions are based on practice guidelines. We herein present, for the first time, 4 cases patients with biopsy-proven who did respond corticosteroids but benefited from rituximab therapy. This report consists a retrospective case series experienced steroid-resistant, COP. Patients included...
Abstract Background Trans‐bronchial forceps biopsy ( TBFB ) is the gold standard to establish presence of allograft rejection or infection after lung transplantation. We aimed analyze diagnostic yield and safety trans‐bronchial cryobiopsy TBCB in allografts. Methods Retrospective analysis 402 TBB procedures 362 recipients was performed between 2011 2016. Half cases (201) were by other half . One hundred random slides specimens from allografts reviewed for artifacts, bleeding, histological...
To evaluate changes in pain threshold before, during and after labor a prospective clinical trial. Forty pregnant women at term were included. Pain 18 specific pressure points was evaluated using dolorimeter. Woman underwent assessment before labor, the active phase of postpartum. Subjective intensity assessed by parturient Verbal Rating Scale (VRS). significantly higher labor. There significant decline as compared to (2.507 ± 0.947 2.608 1.023, respectively, p = 0.01). VRS score than (4.8...
Abstract Background Capnography waveform contains essential information regarding physiological characteristics of the airway and thus indicative level obstruction. Our aim was to develop a capnography-based, point-of-care tool that can estimate obstruction in patients with asthma COPD. Methods Two prospective observational studies conducted between September 2016 May 2018 at Rabin Medical Center, Israel, included healthy, COPD patient groups. Each underwent spirometry test continuous...
Background: Prior studies assessing the diagnostic utility of bronchoscopy for chronic unexplained cough have focused primarily on identifying endobronchial anomalies to determine etiology. On basis our institutional experience, expanding include cultures and biopsies can considerably increase its yield etiology cough. Materials Methods: This retrospective review analyzed bronchoscopies conducted in institution between 2013 2017. Eligibility criteria were which no had been identified before...
Background Patients with idiopathic pulmonary fibrosis (IPF) have significantly higher incidence of lung cancer (LC) relative to the general population. There is a further increase in LC patients IPF subsequent transplant, specifically undergoing single transplant. Objectives To examine and characteristics during follow-up after transplantation (LTX). Methods We conducted retrospective analysis all diagnosed Rabin Medical Center, Israel, over an 11-year period. compared transplanted who did...
AbstractBackground: The interleukin 5 (IL-5) pathway is an important component in the pathophysiology of severe eosinophilic asthma. Mepolizumab a monoclonal antibody that targets IL-5 pathw...
Two doses of mRNA SARS-CoV-2 vaccines elicit an attenuated humoral immune response among immunocompromised patients. Our study aimed to assess the immunogenicity a third dose BNT162b2 vaccine lung transplant recipients (LTRs). We prospectively evaluated by measuring anti-spike and neutralizing antibodies in 139 vaccinated LTRs ~4-6 weeks following dose. The t-cell was IFNγ assay. primary outcome seropositivity rate Secondary outcomes included: positive antibody cellular rate, adverse events,...
PurposeThe world SARS-CoV-2 pandemic has affected global health, including the health of lung transplant recipients. There is very little data reported on outcomes this gruop patientsMethodsRetrospective cohort study approved all LTx recipients with symptoms consistent COVID-19 investigated naso-pharyngeal swabs and reverse PCR for SARS-COV-2. Postive test SARS-COV-2 Inserted to our their files. We also conducted pooled analysis published cases covid 19 recipientsResultsWe identified eleven...
Impaired pulmonary diffusing capacity for carbon monoxide (DLCO) following COVID-19 has been consistently reported among individuals recovering from severe-critical infection. However, most long COVID cases follow non-severe COVID-19. We assessed DLCO with mild to moderate acute illness. A cross-sectional study of adults COVID, at a recovery clinic > 3 months the onset infection, during 2020–2021. Participants subjectively ranked their dyspnea severity based on its impact daily living and...
Abstract Introduction Female lung transplant recipients (LTRs) of reproductive age are increasingly considering pregnancy due to advances in post‐transplant management and improved survival. We report our experience with LTRs, an emphasis on two or more successful full‐term pregnancies individual recipients. Methods conducted a retrospective analysis LTRs at center collected maternal fetal outcomes. Results In patient cohort, eight female conceived total 17 pregnancies, resulting 13...
<b>Background:</b> Malignancy after lung transplantation is an important cause of morbidity and mortality associated with the intensity cumulative dose immunosuppressive drugs. There some evidence that use mammalian target rapamycin (mTOR) inhibitors may reduce risk malignancy in kidney transplant recipients. <b>Aims:</b> To compare effect everolimus on incidence new malignancies, as well rate acute rejection, CMV infection overall survival between recipients who were treated...