Annika Y. Claßen
A5058364058- Neutropenia and Cancer Infections
- COVID-19 Clinical Research Studies
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Long-Term Effects of COVID-19
- Fungal Infections and Studies
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- COVID-19 and healthcare impacts
- Antifungal resistance and susceptibility
- Healthcare cost, quality, practices
- Bacteriophages and microbial interactions
- Sepsis Diagnosis and Treatment
- Surgical site infection prevention
- Cytomegalovirus and herpesvirus research
- Cardiac, Anesthesia and Surgical Outcomes
- Patient Satisfaction in Healthcare
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Tuberculosis Research and Epidemiology
- Inflammasome and immune disorders
- Genomics and Phylogenetic Studies
- Infectious Diseases and Mycology
- Optical Imaging and Spectroscopy Techniques
University Hospital Cologne
2019-2025
University of Cologne
2019-2025
German Center for Infection Research
2019-2025
Heinrich Heine University Düsseldorf
2023-2025
Düsseldorf University Hospital
2023-2025
University of Michigan
2024
Instituto de Salud Carlos III
2024
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2024
Integrated Oncology (United States)
2024
Centrum für Integrierte Onkologie
2021-2023
Abstract Introduction Since the early SARS-CoV-2 pandemic, cancer patients have been assumed to be at higher risk for severe COVID-19. Here, we present an analysis of from LEOSS (Lean European Open Survey on Infected Patients) registry determine whether are risk. Patients and methods We retrospectively analyzed a cohort 435 2636 non-cancer with confirmed infection, enrolled between March 16 August 31, 2020. Data socio-demographics, comorbidities, cancer-related features infection course were...
Abstract Purpose Knowledge regarding patients’ clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance understanding of COVID-19. Methods Sociodemographic and characteristics SARS-CoV-2-infected patients, enrolled LEOSS between March 16, 2020, May 14, were analyzed. Associations baseline stages diagnosis...
Hematologic and oncologic patients with chemo- or immunotherapy-related immunosuppression are at substantial risk for bacterial infections Pneumocystis jirovecii pneumonia (PcP). As resistances increasing worldwide new research reshapes our understanding of the interactions between human host commensals, administration antibacterial prophylaxis has become a matter discussion. This guideline constitutes an update 2013 published Infectious Diseases Working Party (AGIHO) German Society...
Bacteriophage therapy holds promise in addressing the antibiotic-resistance crisis, globally and Germany. Here, we provide an overview of current situation (2023) applied phage supporting research The authors, interdisciplinary group working on patient-focused bacteriophage research, addressed production, banks, susceptibility testing, clinical application, ongoing translational regulatory situation, network structure They identified critical shortcomings including lack trials, a paucity...
Abstract Background and purpose During acute coronavirus disease 2019 (COVID‐19) infection, neurological signs, symptoms complications occur. We aimed to assess their clinical relevance by evaluating real‐world data from a multinational registry. Methods analyzed COVID‐19 patients 127 centers, diagnosed between January 2020 February 2021, registered in the European LEOSS (Lean Open Survey on SARS‐Infected Patients) The effects of prior diseases effect outcome were studied using multivariate...
Background. The management and outcomes of nontuberculous mycobacterial (NTM) infections in solid organ transplant (SOT) recipients are poorly characterized. We aimed to describe the 1-y mortality these patients. Methods. Retrospective, multinational, 1:2 matched case-control study included SOT aged 12 y old or older diagnosed with NTM infection between January 1, 2008, December 31, 2018. Controls were on transplanted organs, treatment center, posttransplant survival at least equal time...
SARS-CoV-2 infection is associated with adverse outcomes in patients cardiovascular disease. Here, we analyzed whether specific biomarkers predict the clinical course of COVID-19 comorbidities.
Abstract Purpose While more advanced COVID-19 necessitates medical interventions and hospitalization, patients with mild do not require this. Identifying at risk of progressing to might guide treatment decisions, particularly for better prioritizing in need hospitalization. Methods We developed a machine learning-based predictor deriving clinical score identifying asymptomatic/mild COVID-19. Clinical data from SARS-CoV-2 positive the multicenter Lean European Open Survey on Infected Patients...
To determine the overall and procedure-specific incidence of surgical site infections (SSI) caused by Staphylococcus aureus (S. aureus) as well risk factors for such across all disciplines in Europe.This is a retrospective cohort patients with procedures performed at 14 European centres 2016, nested case-control analysis. S. SSI were identified semi-automated crossmatching bacteriological electronic health record data. Within each procedure, cases controls matched using optimal propensity...
The Coronavirus Disease-2019 (COVID-19) pandemic has brought opportunities and challenges, especially for health services research based on routine data. In this article we will demonstrate by presenting lessons learned from establishing the currently largest registry in Germany providing a detailed clinical dataset Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) infected patients: Lean European Open Survey SARS-CoV-2 Infected Patients (LEOSS).LEOSS is collaborative integrative approach...
Coagulopathy and venous thromboembolism are common findings in coronavirus disease 2019 (COVID-19) associated with poor outcome. Timely initiation of anticoagulation after hospital admission was shown to be beneficial. In this study we aim examine the association pre-existing oral (OAC) outcome among a cohort SARS-CoV-2 infected patients.
Abstract Background Risk factors for nontuberculous mycobacteria (NTM) infections after solid organ transplant (SOT) are not well characterized. Here we aimed to describe these factors. Methods Retrospective, multinational, 1:2 matched case-control study that included SOT recipients ≥12 years old diagnosed with NTM infection from 1 January 2008 31 December 2018. Controls were on transplanted organ, treatment center, and post-transplant survival greater than or equal the time diagnosis....
The increasing occurrence of hospital-associated infections, particularly bacteremia, caused by extensively drug-resistant (XDR) carbapenemase-producing colistin-resistant Klebsiella pneumoniae highlights a critical requirement to discover new therapeutic alternatives. Bacteriophages having host-specific bacteriolytic effects are promising alternatives for combating these pathogens. Among 12 phages isolated from public wastewater in Thailand, two phages-vB_kpnM_05 (myovirus) and vB_kpnP_08...
Reported antibiotic use in coronavirus disease 2019 (COVID-19) is far higher than the actual rate of reported bacterial co- and superinfection. A better understanding therapy COVID-19 necessary.