A5033388868- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Phagocytosis and Immune Regulation
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Pancreatic function and diabetes
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Nanoparticle-Based Drug Delivery
- TiO2 Photocatalysis and Solar Cells
- Caveolin-1 and cellular processes
- Advanced Photocatalysis Techniques
- Gallbladder and Bile Duct Disorders
- Sphingolipid Metabolism and Signaling
- Extracellular vesicles in disease
- Gastrointestinal disorders and treatments
- COVID-19 Clinical Research Studies
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Pediatric Hepatobiliary Diseases and Treatments
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Renal cell carcinoma treatment
- Bone and Dental Protein Studies
Ludwig-Maximilians-Universität München
2017-2025
LMU Klinikum
2017-2025
Medi-Caps University
2023-2024
München Klinik
2023
Universitätsmedizin Greifswald
2016-2021
Universität Greifswald
2015-2017
Moritz Klinik
2016
Objective Current non-invasive diagnostic tests can distinguish between pancreatic cancer (pancreatic ductal adenocarcinoma (PDAC)) and chronic pancreatitis (CP) in only about two thirds of patients. We have searched for blood-derived metabolite biomarkers this purpose. Design For a case–control study three tertiary referral centres, 914 subjects were prospectively recruited with PDAC (n=271), CP (n=282), liver cirrhosis (n=100) or healthy as well non-pancreatic disease controls (n=261)...
Background & AimsPancreatitis starts with primarily sterile local inflammation that induces systemic inflammatory response syndrome, followed by compensatory anti-inflammatory syndrome (CARS). We investigated the mechanisms of these processes in mice and human serum.MethodsWe induced severe acute pancreatitis partial duct ligation caerulein stimulation or intraperitoneal injection l-arginine deletion interleukin (IL)12B, NLRP3, IL18 given MCC950, a small molecule inhibitor...
Background & AimsAcute pancreatitis is characterized by premature intracellular activation of digestive proteases within pancreatic acini and a consecutive systemic inflammatory response. We investigated how these processes interact during severe in mice.MethodsPancreatitis was induced C57Bl/6 wild-type (control), cathepsin B (CTSB)-knockout, L-knockout mice partial duct ligation with supramaximal caerulein injection, or repetitive injections alone. Immune cells that infiltrated the pancreas...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies and projected to be second leading cause cancer-related death by 2030. Despite extensive knowledge insights into biological properties genetic aberrations PDAC, therapeutic options remain temporary ineffective. One plausible explanation for futile response therapy an insufficient non-specific delivery anticancer drugs tumour site.Superparamagnetic iron oxide nanoparticles (SPIONs) coupled with siRNA directed...
In this study, we synthesized pristine and Cu-doped TiO2 nanoparticles with varying doping concentrations (0.025 M, 0.05 0.075 0.1 M) using the co-precipitation method. Characterization of samples (designated as S1 to S5) was performed X-ray diffraction analysis (XRD), Raman analysis, UV-Vis spectroscopy, field emission scanning electron microscopy (FE-SEM), energy dispersive spectroscopy (EDX). Our findings revealed that possess an anatase phase a tetragonal crystal structure. FE-SEM...
Gold nanorods (AuNRs) have attracted considerable attention in plasmonic photothermal therapy for cancer treatment by exploiting their selective and localized heating effect due to unique photophysical properties. Here we describe a strategy design novel multifunctional platform based on AuNRs to: (i) specifically target the adenocarcinoma MUC-1 marker through use of EPPT-1 peptide, (ii) enhance cellular uptake myristoylated polyarginine peptide (MPAP) (iii) selectively induce cell death...
Objective Chronic pancreatitis (CP) is a fibroinflammatory syndrome leading to organ dysfunction, chronic pain, an increased risk for pancreatic cancer and considerable morbidity. Due lack of specific biomarkers, diagnosis based on symptoms but insensitive imaging features, preventing early appropriate management. Design We conducted type 3 study multivariable prediction individual prognosis according the TRIPOD guidelines. A signature distinguish CP from controls (n=160) was identified...
Pancreatic ductal adenocarcinoma cancer (PDAC) is a highly lethal malignancy requiring efficient detection when the primary tumor still resectable. We previously developed MxPancreasScore comprising 9 analytes and serum carbohydrate antigen 19-9 (CA19-9), achieving an accuracy of 90.6%. The necessity for 5 different analytical platforms multiple runs, however, hindered clinical applicability. therefore aimed to develop simpler single-analytical run, single-platform diagnostic signature.We...
Currently there is a lack of effective methods to accurately detect pancreatic cacer. In our study, we develop liquid biopsy signature EV miRNAs based on associated radiomics features patients’ tumors in order provide new insights for the early diagnosis cancer.A total eight datasets enrolled this featuring clinical and imaging data from different benign lesions malignant cancers as well small RNAseq cargo plasma extracellular vesicles tumor patients. Radiomics Feature Extraction analysis...
Currently there is a lack of effective methods to accurately detect pancreatic cacer. In our study, we develop liquid biopsy signature EV miRNAs based on associated radiomics features patients’ tumors in order provide new insights for the early diagnosis cancer.A total eight datasets enrolled this featuring clinical and imaging data from different benign lesions malignant cancers as well small RNAseq cargo plasma extracellular vesicles tumor patients. Radiomics Feature Extraction analysis...
The quest for efficient and sustainable energy solutions has led to increased interest in dye-sensitized solar cells (DSSCs) utilizing natural dyes. However, enhancing the performance stability of these cells...
Fluoropyrimidine c (5-fluorouracil [5FU]) increasingly represents the chemotherapeutic backbone for neoadjuvant, adjuvant, and palliative treatment of pancreatic ductal adenocarcinoma (PDAC). Even in combination with other agents, 5FU efficacy remains transient limited. One explanation inadequate response is insufficient nonspecific delivery to tumor.
Background and aims Besides well-defined genetic alterations, the dedifferentiation of mature acinar cells is an important prerequisite for pancreatic carcinogenesis. Acinar-specific genes controlling cell homeostasis are extensively downregulated during cancer development; however, underlying mechanisms poorly understood. Now, we devised a novel in vitro strategy to determine genome-wide dynamics epigenetic landscape Design With our carcinogenic sequence, performed global gene expression...
Systemic therapies for pancreatic ductal adenocarcinoma (PDAC) remain unsatisfactory. Clinical prognosis is particularly poor tumor subtypes with activating aberrations in the MYC pathway, creating an urgent need novel therapeutic targets. To unbiasedly find MYC-associated epigenetic dependencies, we conducted a drug screen cancer cell lines. Here, found that protein arginine N-methyltransferase 5 (PRMT5) inhibitors triggered dependency. In human and murine PDACs, robust connection of PRMT5...
Primary sclerosing cholangitis (PSC) represents a chronic liver disease characterized by poor prognosis and lacking causal treatment options. Yes-associated protein (YAP) functions as critical mediator of fibrogenesis; however, its therapeutic potential in biliary diseases such PSC remains unestablished. The objective this study is to elucidate the possible significance YAP inhibition fibrosis examining pathophysiology hepatic stellate cells (HSC) epithelial (BEC). Human tissue samples from...