A5083404181- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Cardiac Arrest and Resuscitation
- Tracheal and airway disorders
- Long-Term Effects of COVID-19
- Asthma and respiratory diseases
- Frailty in Older Adults
- Cardiovascular Syncope and Autonomic Disorders
- Pulmonary Hypertension Research and Treatments
- Sleep and Wakefulness Research
- Family and Patient Care in Intensive Care Units
- Mechanical Circulatory Support Devices
- Sleep and related disorders
- Esophageal and GI Pathology
- Nosocomial Infections in ICU
- Lung Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Health and Medical Studies
- Emergency and Acute Care Studies
- Cardiovascular and exercise physiology
Agaplesion Bethesda Krankenhaus
2016-2025
Helios Universitätsklinikum Wuppertal
2020-2025
Witten/Herdecke University
2008-2025
St. Josef Krankenhaus
2024
Heinrich Heine University Düsseldorf
2015-2019
Krankenhaus Bethanien
2006-2014
Fachkrankenhaus Kloster Grafschaft
2005
University of Duisburg-Essen
2001
BackgroundHypercapnic respiratory failure in patients with COPD frequently requires mechanical ventilatory support. Extracorporeal CO2 removal (ECCO2R) techniques have not been systematically evaluated these patients.MethodsThis is a pilot study of novel ECCO2R device that utilizes single venous catheter high rates at low blood flows. Twenty hypercapnic received ECCO2R. Group 1 (n = 7) consisted receiving noninvasive ventilation likelihood requiring invasive ventilation, group 2 2) who could...
Zusammenfassung Die außerklinische Beatmung über einen invasiven oder nichtinvasiven Beatmungszugang ist mittlerweile etablierter Standard. Entsprechend wurde bereits im Jahr 2010 unter der Federführung Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V. (DGP) die Leitlinie „Nichtinvasive invasive als Therapie chronischen respiratorischen Insuffizienz“ publiziert. stetige Weiterentwicklung technischen Methoden, neue wissenschaftliche Erkenntnisse sowie versorgungsrelevante...
Abstract Study Objectives: The clear discrimination of central and obstructive hypopneas is highly relevant to avoid misinterpretation inappropriate treatment complicated breathing patterns. Esophageal manometry the accepted standard for differentiation phenotypes sleep apnea. However, it limited in its use due poor acceptance by patients therefore rarely performed routine clinical practice. Flattening inspiratory airflow curve, paradoxical breathing, arousal position, stages, pattern at end...
The Covid-19 pandemic has pushed many hospitals to their capacity limits. Therefore, a triage of patients been discussed controversially primarily through an ethical perspective. term contains aspects such as urgency treatment, severity the disease and pre-existing conditions, access critical care, or classification regarding subsequent clinical pathways starting from emergency department. determination is important not only for patient but also planning in hospitals. We examine performance...
Background Awake tracheal intubation may evoke reflex bronchoconstriction in asthmatics. Whether this effect is altered by the choice of local anesthetic used or pretreatment with a beta2-adrenoceptor agonist unknown. Therefore, we assessed awake fiberoptic after lidocaine dyclonine inhalation without salbutamol on lung function asthmatic volunteers. Methods Bronchial hyperreactivity was verified an inhalational histamine challenge. On four different days randomized, double blind fashion...
Abstract Purpose While more advanced COVID-19 necessitates medical interventions and hospitalization, patients with mild do not require this. Identifying at risk of progressing to might guide treatment decisions, particularly for better prioritizing in need hospitalization. Methods We developed a machine learning-based predictor deriving clinical score identifying asymptomatic/mild COVID-19. Clinical data from SARS-CoV-2 positive the multicenter Lean European Open Survey on Infected Patients...
<i>Background:</i> Long-term compliance is suboptimal in the treatment of obstructive sleep apnea syndrome (OSAS). <i>Objectives:</i> We compared efficacy and adherence to automatic continuous positive airway pressure (APAP) constant (CPAP) based on a night-by-night analysis. <i>Methods:</i> performed randomized, single-blind crossover study 20 patients with moderate-to-severe OSAS. After diagnostic polysomnography manual titration, were treated for 8...
Background In standard textbooks, intravenous lidocaine is recommended for intubation of patients with bronchial hyperreactivity. However, whether and to what extent local anesthetics attenuate hyperreactivity in humans unknown. Accordingly, nine awake volunteers known were subjected an inhalational challenge acetylcholine before during infusion lidocaine, bupivacaine, or placebo a randomized, double-blinded fashion. Methods Baseline threshold concentrations determined 3-5 days initiation...
Conventional and electromagnetic navigation bronchoscopy (ENB) is generally used as a diagnostic tool in suspicious pulmonary nodules. The use of this technique for the placement fiducial markers patients with inoperable but early-stage lung cancer could present an innovative approach enabling risk-reduced therapy.We seven clinical cases where conventional ENB were part experimental interdisciplinary to management therapy planning. In each case, we analyzed indication, endoscopic procedures...
<h3>BACKGROUND:</h3> Measurement of P<sub>CO<sub>2</sub></sub> is vital in determining effective alveolar ventilation. However, obtaining capillary by a skin prick the earlobe painful, and nocturnal measurements disturb sleep. End-expiratory measurement also well established, but there low precision predicting arterial or CO<sub>2</sub>. The purpose study was to evaluate noninvasive, transcutaneous (P<sub>tcCO<sub>2</sub></sub>) hypercapnic subjects. <h3>METHODS:</h3> In this prospective...
<i>Background:</i> The measurement of CO<sub>2</sub> partial pressure (P<i>CO</i><sub>2</sub>) is great importance. Former systems transcutaneous capnometry combining the oxygen (P<i>O</i><sub>2</sub>) and P<i>CO</i><sub>2</sub> had their limitations due to skin irritations caused by heating-up sensor a short application time 4 h. <i>Objectives:</i> To evaluate for first combined...
We aimed to assess symptoms in patients after SARS-CoV-2 infection and identify factors predicting prolonged time symptom-free.COVIDOM/NAPKON-POP is a population-based prospective cohort of adults whose first on-site visits were scheduled ≥ 6 months positive PCR test. Retrospective data including self-reported symptom-free collected during the survey before site visit. In survival analyses, being served as event be variable. Data visualized with Kaplan-Meier curves, differences tested...
Recently, taurolidine has been intensively studied on a variety of in-vitro cancer cell-lines and first data exhibit encouraging antitumoral effects. While the clinical use is considered, some studies with in-vivo experiments contradict this beneficial effect even indicate advanced growth. The aim study to further investigate paradox by closely analyze interaction cells surrounding environment following exposure.HT-29 (ATCC® HTB-38™) were treated at different concentrations oxaliplatin using...