A5030005930- Pulmonary Hypertension Research and Treatments
- Obstructive Sleep Apnea Research
- Neurobiology of Language and Bilingualism
- Tracheal and airway disorders
- Neuroscience of respiration and sleep
- Vascular Anomalies and Treatments
- Respiratory Support and Mechanisms
- Cardiac Imaging and Diagnostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genomics and Chromatin Dynamics
- Congenital Heart Disease Studies
- Lung Cancer Diagnosis and Treatment
- Cardiovascular and exercise physiology
- CRISPR and Genetic Engineering
- Cancer Immunotherapy and Biomarkers
- Sleep and Wakefulness Research
- Vascular anomalies and interventions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Dementia and Cognitive Impairment Research
- Dysphagia Assessment and Management
- Radiation Dose and Imaging
- Linguistic research and analysis
- Medical Practices and Rehabilitation
- Language Development and Disorders
- Healthcare Systems and Technology
European Molecular Biology Laboratory
2021-2024
Bielefeld University
2011-2022
European Molecular Biology Laboratory
2022
University of Cologne
2017-2020
Praxis
2020
Krankenhaus Bethanien
2006-2019
Witten/Herdecke University
2012-2014
Städtisches Klinikum Solingen
2011
Klinikum Osnabrück
2010
Anheuser-Busch InBev (Belgium)
2009
Developmental enhancers bind transcription factors and dictate patterns of gene expression during development. Their molecular evolution can underlie phenotypical evolution, but the contributions evolutionary pathways involved remain little understood. Here, using mutation libraries in Drosophila melanogaster embryos, we observed that most point mutations developmental led to changes levels rarely resulted novel outside native pattern. In contrast, random sequences, often acting as...
Abstract Although the effects of genetic and environmental perturbations on multicellular organisms are rarely restricted to single phenotypic layers, our current understanding how developmental programs react these challenges remains limited. Here, we have examined consequences disturbing bicoid regulatory network in early Drosophila embryos. We generated flies with two extra copies , which causes a posterior shift network’s outputs decrease fitness. subjected EMS mutagenesis, followed by...
<i>Background:</i> Long-term compliance is suboptimal in the treatment of obstructive sleep apnea syndrome (OSAS). <i>Objectives:</i> We compared efficacy and adherence to automatic continuous positive airway pressure (APAP) constant (CPAP) based on a night-by-night analysis. <i>Methods:</i> performed randomized, single-blind crossover study 20 patients with moderate-to-severe OSAS. After diagnostic polysomnography manual titration, were treated for 8...
The purpose of this study was to explore the impact anterior cervical discectomy and fusion (ACDF) with instrumentation on swallowing function physiology as measured videofluoroscopic studies.We retrospectively analyzed both functional measures (penetration-aspiration, residue) physiological/anatomical (hyoid excursion, posterior pharyngeal wall thickness) in a series 17 patients (8 men, 9 women, mean age 54 years). These were extracted from calibrated 5-ml boluses thin radio-opaque liquids...
Abstract A significant challenge for developmental systems biology is balancing throughput with controlled conditions that minimize experimental artifacts. Large-scale screens such as unbiased mutagenesis surveys have been limited in their applicability to embryonic systems, the technologies quantifying precise expression patterns whole animals has not kept pace other sequencing-based technologies. Here, we outline an open-source semi-automated pipeline chemically fixate, stain, and 3D-image...
The serum- and glucocorticoid-regulated kinase (sgk1) is induced by mineralocorticoids and, in turn, upregulates heterologously expressed renal epithelial Na+ channel (ENaC) activity Xenopus oocytes. Accordingly, Sgk1 considered to mediate the mineralocorticoid stimulation of ENaC antinatriuresis. Here we show that at standard NaCl intake, water electrolyte excretion indistinguishable sgk1-knockout (sgk1–/–) mice wild-type (sgk1+/+) mice. In contrast, dietary restriction reveals an impaired...
ABSTRACT Developmental enhancers are DNA sequences that when bound to transcription factors dictate specific patterns of gene expression during development. It has been proposed the evolution such cis-regulatory elements is a major source adaptive evolution; however, regulatory and evolutionary potential remains little understood, masked by selective constraints, drift contingency. Here, using mutation libraries in Drosophila melanogaster embryos, we observed most mutations classical...
This study aims to test the predictive power of gene expression data derived from NIHs database dbEST, which collects results a large number and variety DNA array experiments. The motivation this is make comparable experimental studies, are usually performed only for one or few tissues organs, with wide other tissues. Confirmation good dbEST would put interesting partially surprising recent findings, solely based on mining, more solid basis than available so far. nine genes (eIF4E, DDX6,...
Zusammenfassung Hintergrund Mild Cognitive Impairment (MCI) ist häufig mit Veränderungen sprachlicher und kommunikativer Kompetenzen verbunden. Zur differenzierten Erfassung dieser sprachlichen bei MCI stehen allgemein keine spezifischen Diagnostikinstrumente zur Verfügung. Die vorliegende Studie untersucht, inwiefern die Verfahren BIAS R ANELT, entwickelt Diagnostik neurologisch bedingter Sprachstörungen, im Rahmen eines detektieren können. Methode Auf Grundlage des kognitiven Status,...
Es werden zwei Fälle von arteriovenösen Fisteln der Lunge mitgeteilt, denen eine wegen Kombination mit einem Vorhofseptumdefekt und zweite durch die Lokalisation in allen 5 Lungenlappen ausgesprochen seltene Beobachtungen sind. Die einer Lungenfistel Vorhofseptumdefekt, bisher nur einmal beschrieben wurde, zeichnet sich unserem Fall dadurch aus, daß Herzschatten Fistel nicht zu erklärende starke Vergrößerung kräftigen Pulsationen des Pulmonalisbogens aufweist Lungenzeichnung lokal zu-...
<b>Background</b> Transbronchial Cryobiopsy (TCB) is an endoscopy technique which can be applied for tissue sampling in diagnosis of interstitial lung diseases (ILD). We could show that this method results a definitive clinical 70% cases (Clin Respir J. 2015 Jan 26, Epub ahead print). It remains unclear how often surgical biopsy (SLB) either leads to change or confirmation histological when TCB are non-definitive. <b>Methods:</b> Data 12 ILD patients (8 retrospective, 4 prospective) were...
Unter 1000 kongenitalen und erworbenen Vitien fanden sich nur acht Fälle mit einer hämodynamisch wirksamen Pulmonalinsuffizienz. Funf waren postoperativ nach Sprengung valvularen Pulmonalstenose aufgetreten, drei funktionell entstanden. In einem weiteren Fall war die Regurgitation bedeutungslos. Die Gründe fur das seltene Vorkommen werden diskutiert zur Frage der Erkennbarkeit des Vitiums einfachen rontgenologischen Methoden wird Stellung genommen. Als diagnostisch hinweisend sind kräftige...
<b>Background:</b> Interstitial lung diseases (ILD) comprise a heterogeneous group of different entities. Retrospective data show that IPF patients with reduced capacity in cardiopulmonary exercise testing (CET) have higher mortality (Fell, C. <i>et al.</i> AJRCCM 2009; 179:402-407). Our aim is to evaluate the significance CET context early detection, disease progress and therapy monitoring compared other pulmonary function tests. <b>Methods:</b> We present prospective, monocentric,...