A5012364931- Streptococcal Infections and Treatments
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Otolaryngology and Infectious Diseases
- Antimicrobial Resistance in Staphylococcus
- Cellular Mechanics and Interactions
- COVID-19 and Mental Health
- Neonatal and Maternal Infections
- Erythrocyte Function and Pathophysiology
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Cell Image Analysis Techniques
- Immunodeficiency and Autoimmune Disorders
- Microfluidic and Bio-sensing Technologies
- RNA Research and Splicing
- Caveolin-1 and cellular processes
- Pharmaceutical studies and practices
- COVID-19 and healthcare impacts
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Bacterial Identification and Susceptibility Testing
University Hospital Carl Gustav Carus
2016-2025
TU Dresden
2016-2025
Klinik und Poliklinik für Kinder- und Jugendmedizin
2015-2025
Jena University Hospital
2024
Friedrich Schiller University Jena
2024
University Hospital Cologne
2023
University of Cologne
2023
University of Cambridge
2017-2018
Papworth Hospital
2017
University Medical Center Freiburg
2011
Background Long-term health sequelae of the Coronavirus Disease 2019 (COVID-19) are a major public concern. However, evidence on post-acute COVID-19 syndrome (post-COVID-19) is still limited, particularly for children and adolescents. Utilizing comprehensive healthcare data approximately 46% German population, we investigated post-COVID-19-associated morbidity in children/adolescents adults. Methods findings We used routine from statutory insurance organizations covering period between...
In late 2022, health care institutions in Germany reported an unusual number of severe, invasive bacterial infections association with a high incidence viral respiratory infections.
Blood is arguably the most important bodily fluid and its analysis provides crucial health status information. A first routine measure to narrow down diagnosis in clinical practice differential blood count, determining frequency of all major cells. What lacking advance initial diagnostics an unbiased quick functional assessment that can generate specific hypotheses. To address this need, we introduce continuous, cell-by-cell morpho-rheological (MORE) diluted whole blood, without labeling,...
In vivo–mimicking mechanical deformations quickly depolarize neutrophils—a mechanism potentially failing in acute lung injury.
Low-density granulocytes (LDGs) are a distinct subset of proinflammatory and vasculopathic neutrophils expanded in systemic lupus erythematosus (SLE). Neutrophil trafficking immune function intimately linked to cellular biophysical properties. This study used proteomic, biomechanical functional analyses further define neutrophil heterogeneity the context SLE.Proteomic/phosphoproteomic were performed healthy control (HC) normal density (NDNs), SLE NDNs autologous LDGs. The properties these...
Abstract It has become increasingly apparent that the biomechanical properties of neutrophils impact on their trafficking through circulation and in particularly pulmonary capillary bed. The retention polarized or shape-changed lungs was recently proposed to contribute acute respiratory distress syndrome pathogenesis. Accordingly, this study tested hypothesis neutrophil priming is coupled morpho-rheological (MORE) changes capable altering cell function. We employ real-time deformability...
Abstract Background Long-term health sequelae of the coronavirus disease 2019 (COVID-19) are a major public concern. However, evidence on post-acute COVID-19 syndrome (post COVID-19) is still limited, particularly for children and adolescents. Utilizing comprehensive healthcare data more than 45 percent German population from January through December 2020, we investigated post in children/adolescents adults. Methods From total 38 million individuals, identified all patients with laboratory...
Abstract Purpose The objective examination of the Post-COVID syndrome (PCS) remains difficult due to heterogeneous definitions and clinical phenotypes. aim study was verify functionality correlates a recently developed PCS score. Methods score applied prospective, multi-center cross-sectoral cohort (in- outpatients with SARS-CoV-2 infection) "National Pandemic Cohort Network (NAPKON, Germany)". Symptom assessment patient-reported outcome measure questionnaires were analyzed at 3 12 months...
In winter 2022/2023, a resurgence of invasive group A streptococcal (iGAS) infections in children was observed Europe, including Germany and Switzerland. While simultaneous increase consultations for scarlet fever pharyngitis reported England, leading to the recommendation treat any suspected GAS disease with antibiotics, guidelines Switzerland remained unchanged. We aimed investigate whether this policy appropriate.
Immune cells face constant changes in their microenvironment, which requires rapid metabolic adaptation. In contrast to neutrophils, are known rely near exclusively on glycolysis, the profile of human eosinophils has not been characterized. Here, we assess key parameters peripheral blood-derived using real-time extracellular flux analysis measure acidification rate and oxygen consumption rate, compare these neutrophils. Using this methodology, demonstrate that neutrophils have a similar...
Abstract Purpose Despite the need to generate valid and reliable estimates of protection levels against SARS-CoV-2 infection severe course COVID-19 for German population in summer 2022, there was a lack systematically collected population-based data allowing assessment level real time. Methods In IMMUNEBRIDGE project, we harmonised biosamples nine population-/hospital-based studies (total number participants n = 33,637) provide between June November 2022. Based on evidence synthesis, formed...
Vulnerability to infectious diseases in refugees is dependent on country of origin, flight routes, and conditions. Information specific medical needs different groups lacking. We assessed the prevalence diseases, immunity vaccine-preventable chronic conditions children, adolescents, adult from Ukraine who arrived Germany 2022. Using media, we recruited Ukrainian at 13 sites between 9-12/2022. An antigen test for acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, serologies...