A5000735364- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Diagnosis and treatment of tuberculosis
- Health and Medical Studies
- Pneumonia and Respiratory Infections
- Migration, Health and Trauma
- Infectious Diseases and Tuberculosis
- Long-Term Effects of COVID-19
- Pneumocystis jirovecii pneumonia detection and treatment
- Child and Adolescent Health
- Medical and Pharmaceutic Studies
- Acute Lymphoblastic Leukemia research
- Antimicrobial Peptides and Activities
- Pharmacological Effects of Natural Compounds
- COVID-19 and Mental Health
- Misinformation and Its Impacts
- Vaccine Coverage and Hesitancy
- Metabolism and Genetic Disorders
- Hepatitis B Virus Studies
- Ideological and Political Education
- Respiratory viral infections research
Helmholtz Centre for Infection Research
2022-2024
Kharkiv National Medical University
2018-2022
Abstract Purpose Despite the need to generate valid and reliable estimates of protection levels against SARS-CoV-2 infection severe course COVID-19 for German population in summer 2022, there was a lack systematically collected population-based data allowing assessment level real time. Methods In IMMUNEBRIDGE project, we harmonised biosamples nine population-/hospital-based studies (total number participants n = 33,637) provide between June November 2022. Based on evidence synthesis, formed...
The study evaluates the effects on sero-immunity, health status and quality of life children adolescents after upsurge Omicron variant in Germany.This multicenter cross-sectional (IMMUNEBRIDGE Kids) was conducted within German Network University Medicine (NUM) from July to October 2022. SARS-CoV-2- antibodies were measured data SARS-CoV-2 infections, vaccinations, socioeconomic factors as well caregiver-reported evaluation their children's psychological assessed.497 aged 2-17 years included....
Vulnerability to infectious diseases in refugees is dependent on country of origin, flight routes, and conditions. Information specific medical needs different groups lacking. We assessed the prevalence diseases, immunity vaccine-preventable chronic conditions children, adolescents, adult from Ukraine who arrived Germany 2022. Using media, we recruited Ukrainian at 13 sites between 9-12/2022. An antigen test for acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, serologies...
IntroductionThroughout the SARS-CoV-2 pandemic, Germany like other countries lacked adaptive population-based panels to monitor spread of epidemic diseases.MethodsTo fill a gap estimates needed for winter 2022/23 we resampled in German cohort study MuSPAD mid-2022, including characterization systemic cellular and humoral immune responses by interferon-γ-release assay (IGRA) CLIA/IVN assay. We were able confirm categorization our population into four groups with differing protection levels...
Abstract Despite the need to generate valid and reliable estimates of protection against SARS-CoV-2 infection severe course COVID-19 for German population in summer 2022, there was a lack systematically collected population-based data allowing assessment level real-time. In IMMUNEBRIDGE project, we harmonised biosamples nine population-/hospital-based studies (total number participants n=33,637) provide levels between June November 2022. Based on evidence synthesis, formed combined endpoint...
Abstract Throughout the SARS-CoV-2 pandemic, Germany lacked an adaptive population panel for epidemic diseases and a modelling platform to rapidly incorporate estimates. We evaluated how cross-sectional analysis of 9922 participants MuSPAD study in June/July 2022 combined with newly developed could bridge gap analyzed antibody levels, neutralizing serum activity interferon-gamma release response samples. categorized into four groups differing protection against severe course disease...
In 2022, over 1,000,000 people from Ukraine fled to Germany, mostly women and children. The aim of this study was determine health status socio-demographic background Ukrainian refugee minors in Germany compare that German minors. study, refugees all ages, who voluntarily made contact with the centres via flyers or shelters, were interviewed help trained interpreters 09-12/2022. We assessed data their families on socio-economic status, general perception, current pre-existing infectious...
L'étude des types de la mort cellulaire et les stades l'apoptose leucocytes chez patients atteints tuberculose pulmonaire aux différents programmes traitement antimycobactérien L'objectif.D'évaluer l'état membranes cytoplasmiques étudier leur viabilité, déterminer variétés avec traités par schémas antimycobactérien.Matériaux méthodes.L'étude a été réalisée sur 30 pulmonaire: 1er groupe -12 un schéma thérapeutique standard médicaments en ligne; 2-ème groupe-patients individuellement gamme I...
Search of ways to improve the treatment efficacy pulmonary tuberculosis is main task phthisiology at present stage its development. According our opinion, one such way prediction outcomes anti-tuberculosis therapy intensive phase initial stage, which will allow make correction regimen opportunely.The aim study was determine informative indicators for predicting patients with in therapy. Based on results, create a model regimen.Materials and methods: 80 active tuberculosis, were registered...
<b>Aim:</b> To assess the modes of cell death white blood cells (WBCs) in patients with community-acquired pneumonia (CAP) and pulmonary tuberculosis (PTB). <b>Materials methods:</b> Flow cytometry analysis (FCA) was performed 12 CAP, 30 PTB 22 volunteers. FCA using FITC-labeled annexin V (AV), anti-CD45 PE 7-aminoactinomycin D (7-AAD) markers to evaluate amount viable, early apoptotic, late apoptotic/necrotic, dead necrotic circulating WBCs on a flow cytometer. <b>Results:</b> The...
Einleitung In spring 2022, Germany lacked systematically collected population-based SARS-CoV-2 data allowing real-time assessment of protection levels against severe course COVID-19. To fill this gap, the IMMUNEBRIDGE project, a joint collaboration eight population- and one hospital-based studies, was launched.
Isoniazid is one of the most effective anti-tuberculosis drugs, and resistance to it a problem for phthysiology doctors.Objective. To study prevalence isoniazid-resistant tuberculosis in Kharkiv region, term administration an individual regimen, analyze results treatment, determine optimal regimen duration treatment.Material Methods. The statistical forms I line drugs case histories 100 patients diagnosed with pulmonary period from 2012 2016 years were studied. Group 1 included 45...
Objective — to evaluate the condition of cytoplasmic membranes leukocytes and study their viability, determine varieties stages cell death in patients with pulmonary tuberculosis (TB) different treatment efficacy intensive phase (IP) antimycobacterial therapy (AMBT).Materials methods. The involved 30 an established diagnosis TB who were treated at Regional Tuberculosis Hospital N 1 (Kharkiv). Patients divided into groups depending on effectiveness IP AMBT. first group included 12 effective...
Currently used X-ray and laboratory methods for monitoring the effectiveness of TB treatment are not always convenient, because they give a delayed result, as in case sputum culture or difficult to perform, example, patients with poor production following instructions. The aim study was develop mathematical model predicting MDR-TB based on Human-beta-defensin-1 level <b>Materials methods:</b> 50 pulmonary were included study. A generated by discriminant functional analysis using (HBD-1) at...