A5001777782- Cardiac Arrest and Resuscitation
- Thyroid Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Ethics in Clinical Research
- Cardiac electrophysiology and arrhythmias
- S100 Proteins and Annexins
- SARS-CoV-2 and COVID-19 Research
- Clinical practice guidelines implementation
- Plasma Applications and Diagnostics
- Neurological disorders and treatments
- COVID-19 Clinical Research Studies
- Clinical Laboratory Practices and Quality Control
- Birth, Development, and Health
- Molecular Biology Techniques and Applications
- Biosimilars and Bioanalytical Methods
- Hepatocellular Carcinoma Treatment and Prognosis
- Diabetes Management and Research
- Polyamine Metabolism and Applications
- Business Process Modeling and Analysis
- Plasma Diagnostics and Applications
- Cardiovascular Effects of Exercise
- Bacterial Identification and Susceptibility Testing
- Neonatal Health and Biochemistry
Universitätsmedizin Greifswald
2015-2024
Universität Greifswald
2007-2019
Medizinische Hochschule Hannover
2016-2017
University of Basel
1993-1994
... The Study of Health in Pomerania (SHIP) comprises the two independent cohorts SHIP-START (recruited between 1997 and 2001) SHIP-TREND 2008 to 2012), which were established examine health disease status general adult population Northeast Germany given that this region had lowest life expectancy 1990s.1 initial cohort was renamed avoid confusion with designation SHIP, as whole project different cohorts. Both serve purpose understanding concepts their greatest possible complexity, rather...
Summary Disulphide bond formation catalysed by thiol‐disulphide oxidoreductases (TDORs) is a universally conserved mechanism for stabilizing extracytoplasmic proteins. In Escherichia coli , disulphide requires concerted action of distinct TDORs in thiol oxidation and subsequent quinone reduction. TDOR function other bacteria has remained largely unexplored. Here we focus on low‐GC Gram‐positive bacteria, particular DsbA Staphylococcus aureus BdbA‐D Bacillus subtilis . Phylogenetic analyses...
Plasma medicine and also decontamination of bacteria with physical plasmas is a promising new field life science huge interest especially for medical applications. Despite numerous successful applications low temperature gas in decontamination, the fundamental nature interactions between plasma microorganisms to large extent unknown. A detailed knowledge these essential development as well enhancement established plasma-treatment procedures. In present work we introduce first time growth...
Machine learning methods show promise to translate univariate biomarker findings into clinically useful multivariate decision support systems. At current, works in major depressive disorder have predominantly focused on neuroimaging and clinical predictor modalities, with genetic, blood-biomarker, cardiovascular modalities lacking. In addition, the prediction of rehospitalization after an initial inpatient episode is yet be explored, despite its importance. To address this gap literature, we...
Abstract Purpose Despite the need to generate valid and reliable estimates of protection levels against SARS-CoV-2 infection severe course COVID-19 for German population in summer 2022, there was a lack systematically collected population-based data allowing assessment level real time. Methods In IMMUNEBRIDGE project, we harmonised biosamples nine population-/hospital-based studies (total number participants n = 33,637) provide between June November 2022. Based on evidence synthesis, formed...
ABSTRACT The Gram-positive pathogen Staphylococcus aureus secretes various proteins into its extracellular milieu. Bioinformatics analyses have indicated that most of these are directed to the canonical Sec pathway, which consists translocation motor SecA and a membrane-embedded channel composed SecY, SecE, SecG proteins. In addition, S. contains an accessory Sec2 pathway involving SecA2 SecY2 Here, we addressed roles nonessential components in biogenesis proteome . results show is major...
Twin-arginine protein translocation (Tat) pathways are required for transport of folded proteins across bacterial, archaeal and chloroplast membranes. Recent studies indicate that Tat has evolved into a mainstream pathway secretion in certain halophilic archaea, which thrive highly saline environments. Here, we investigated the effects environmental salinity on Tat-dependent by Gram-positive soil bacterium Bacillus subtilis, encounters widely differing salt concentrations its natural...
In 2017, in the Polish-German transborder area of West Pomerania, Mecklenburg-Western and Brandenburg, collaboration with two centers Warsaw, a partnership field newborn screening (NBS) for severe primary immunodeficiency diseases (PID), mainly combined (SCID), was initiated. SCID, but also some other PID, is group disorders characterized by absence T and/or B NK cells. Affected infants are susceptible to life-threatening infections, early detection gives chance effective treatment. The...
The study evaluates the effects on sero-immunity, health status and quality of life children adolescents after upsurge Omicron variant in Germany.This multicenter cross-sectional (IMMUNEBRIDGE Kids) was conducted within German Network University Medicine (NUM) from July to October 2022. SARS-CoV-2- antibodies were measured data SARS-CoV-2 infections, vaccinations, socioeconomic factors as well caregiver-reported evaluation their children's psychological assessed.497 aged 2-17 years included....
The Integrated Research Biobank (IRB) at the Institute of Clinical Chemistry and Laboratory Medicine (IKCL) is central biobank resource University Greifswald (UMG) for all biological materials collected within framework clinical experimental studies carried out by internal external researchers. IRB a core unit UMG focuses on collection, processing storage mainly liquid biomaterials, e.g. blood, urine, saliva or swaps in established workflows thereby securing highest quality standards....
The applications of low-temperature plasma are not only confined to decontamination and sterilization but also found in the medical field terms wound skin treatment. For improvement already established for new techniques, in-depth knowledge on interactions between microorganism is essential. In an initial study, interaction growing Bacillus subtilis argon was investigated by using a growth chamber system suitable gas treatment bacteria liquid medium. this follow-up investigation, second kind...
Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers. Several local systemic therapies are available for patients with HCC depending on stage disease. In clinical practice, treatment decision-making, sequencing may be very heterogeneous.In this study, we retrospectively analyzed algorithms in 2101 treated from 2000 to 2015 at Hannover Medical School, Germany.Transarterial chemoembolization was common initial (n = 545; 25.9%), followed by resection 435, 20.7%),...
Abstract Long transportation times of samples can occur due to centralization laboratories, and also in, for instance epidemiological multicenter studies with one core laboratory. Unsatisfactory glycolysis inhibition is known threaten the correct measurements glucose concentration in patient samples. In former Terumo Glycaemia tubes proved be superior other anticoagulant systems time periods up 24 h. We investigated long-term stability 96 h at room temperature imitated transport conditions...
Abstract Background: The innovative pneumatic tube system (iPTS) transports one sample at a time without the use of cartridges and allows rapid sending samples directly into bulk loader laboratory automation (LAS). We investigated effects iPTS on turn-around (TAT). Methods: During transport, mini data logger recorded accelerations in three dimensions reported them arbitrary area under curve (AUC) units. In addition representative quantities clinical chemistry, hematology coagulation were...
Biobanks are important infrastructures facilitating biomedical research. After a decade of rolling out such infrastructures, shift in attention to the sustainability biobanks could be observed recent years. In this regard, an increase as yet relatively low utilisation rates has been formulated goal. Higher can only achieved if perspectives potential users biobanks-particularly researchers not collaborating with biobanks-are adequately considered. To better understand their perspectives,...
Abstract Background: Newborn screening (NBS) is an established procedure in many countries worldwide, aiming at the early detection of inborn errors metabolism. For decades, dried blood spots have been standard specimen for NBS. The collection well described and standardized includes critical pre-analytical steps. We examined impact contamination some anticipated common substances on NBS results obtained from dry spot samples. This possible source uncertainty has poorly past. Methods:...
Measuring the glucose concentration in whole blood samples is critical due to unsatisfactory glycolysis inhibition. Previous studies showed that Terumo tubes were superior, but they taken off European market 2016 and alternatives required. This initiated present evaluation of stability five available tube types.Venous collected from 61 healthy volunteers test supplied by (two sets), Greiner FC-Mix, BD FX-Mixture serum. After sampling, contents thoroughly mixed centrifuged within an hour. The...
Long patient transport times to trauma centers are a well-known problem in sparsely populated regions with low hospital density. Transfusion of red blood cell concentrates (RBC) and plasma improves outcome patients severe bleeding. Helicopter emergency services (HEMS) frequently employed provide early advanced medical care reduce time admission. Supplying HEMS products allows prehospital transfusion may help prevent exsanguination or prolonged hemorrhagic shock. We have investigated the...
The quality of biospecimens stored in a biobank depends tremendously on the technical personnel responsible for processing, storage, and release biospecimens. Adequate training these employees would allow harmonization correct sample handling thus ensure high comparable samples across locations. However, Germany there are no specific opportunities staff. To understand educational needs web-based survey was sent to all national biobanks via established e-mail registers. In total, 79 completed...
Electrophysiological studies have shown that somatostatin (SOM; 10(-8) and 10(-7) M) causes a hyperpolarization of the majority astrocytes in explant cultures rat spinal cord cortex. When SOM cholinergic agonists muscarine nicotine (10(-6) were tested on same cell, all three compounds produced hyperpolarizations, suggesting colocalization functional receptors glial membrane. Combined immunohistochemical autoradiographic binding demonstrating almost which immunostained by monoclonal...
Abstract Despite the need to generate valid and reliable estimates of protection against SARS-CoV-2 infection severe course COVID-19 for German population in summer 2022, there was a lack systematically collected population-based data allowing assessment level real-time. In IMMUNEBRIDGE project, we harmonised biosamples nine population-/hospital-based studies (total number participants n=33,637) provide levels between June November 2022. Based on evidence synthesis, formed combined endpoint...