Gestational diabetes mellitus (GDM) is the most frequent complication during pregnancy. Untreated GDM a severe threat to maternal and neonatal health. Based on recent evidence, up 15% of all pregnancies may be affected by GDM. We hypothesized that in rural birth cohort, higher BMI adverse socioeconomic conditions would promote GDM, which turn lead effects pregnancy outcomes.

The subject of “pregnancy and disease” is particular importance for maternal well-being neonatal outcomes. international literature has focused on acute diseases during pregnancy; however, there are only a few studies investigating chronic in pregnant women. focus this study women childbearing age that not related to the pregnancy. objective paper deliver population based prevalences dieases compare two groups chronically ill healthy detail regarding sociodemography, peri- prenatal...

Some etiological factors involved in developmental dysplasia of the hip (DDH) occur last trimester pregnancy, which could result a decreased incidence DDH preterm infants. The aim this study was to compare between and term Ultrasound joint performed 2,534 infants 376 within population-based Survey Neonates Pomerania (SNiP) study. A total 42 (1.66%) had (Graf type II c, 0.8%; D, 0.3% left 0.4% right; III a, 0.2% left). Eighteen bilateral findings. Hip occurred more frequently female neonates...

<b><i>Background:</i></b> Newborns are prone to infections, which independent predictors of neonatal mortality and morbidity. Neutrophil extracellular traps (NETs) structures composed chromatin antimicrobial molecules that capture kill pathogens. NETs may play an important role in the innate immune system and, thus, might be associated with impaired function. <b><i>Objectives:</i></b> This study aimed compare NET formation between term neonates...

Purpose: NovaTears®+Omega-3 is a water-free eye drop solution with non-animal-derived omega-3 fatty acids. It allows to supplement acids directly in the tear film of patients dry disease (DED). This post-market clinical follow-up (PMCF) study evaluated for first time effects on signs and patient symptoms DED, safety tolerability NovaTears+Omega-3 (0.2%) drops, when used accordance its approved label. Methods: A prospective, multicenter, single-arm, uncontrolled, open-label observational...

Abstract Aim This study analysed the comparative cost of feeding donor human milk to preterm infants compared mother's own and formula. Methods A document process analysis a time measurement were carried out at bank Level 1 Perinatal Center University Hospital Greifswald, Germany, from April June 2017. The data provided by University's financial department. Results total per year was €92 085.02 for 300 litres milk: 27% this material costs, 51% personnel 22% other overheads. average litre...

Neonatal health is of major concern to parents, midwives, physicians and society as a whole, yet prospective population-based birth cohort collect comprehensive data on multiple issues including medical, social, environmental genetic aspects remains be established in Germany. The survey newborns Pomerania (SNiP) described this paper attempts take up goal. objectives SNiP are establish (a) providing detailed information about neonatal health, morbidity mortality, (b) biobank with newborn DNA...

Congenital anomalies of the kidneys and urinary tract (CAKUT) are among most common in newborn infants, may cause chronic renal disease newborns. We investigated sensitivity specificity different ultrasound-based screening strategies for CAKUT.Newborns (n = 4331) were analyzed CAKUT at least one ultrasound examination as a part Survey Neonates Pomerania (SNiP), 7-year population-based study on neonates Western (Germany). Intrauterine examinations compared with early postnatal findings (from...

Congenital toxoplasmosis is associated with severe complications. German state health insurance covers rubella, but not toxoplasmosis, immunity screening. We analysed the effect of socioeconomic factors on efficiency private screening during pregnancy. Toxoplasmosis and rubella data (n = 5402 mothers) were collected within population-based Survey Neonates in Pomerania (SNiP). At first-trimester screening, 34.4 % (88.1 %) expecting mothers immune to (rubella). Susceptibility for (rubella) was...

Abstract Objective Maternal pre-pregnancy underweight, overweight and obesity might increase the risk for worse short- long-term outcome in offspring. There is a need further study into relationship between maternal body mass index (BMI) combined of physical development, state health social behavior children. Question: Is BMI associated with child terms (school leisure time behavior) at age 9 to 15 years? Methods In population-based birth cohort Survey Neonates Pomerania (SNIP) children 9–15...

The Nationale Stillkommission was founded in Germany 1994 to increase the acceptance of breastfeeding as primary means infant nutrition. Scientific studies like "Stillen und Säuglingsernährung (SuSe-Studie)", and regional Bavaria, Freiburg, Hamburg, Berlin demonstrated initiation rates 90 95%, but total rate decreased 25–61% after infants were 6 months old. One predictor duration may be maternal motivation. present study aimed describe We analysed data collected 2004–2008, during a previous...

The Survey of Neonates in Pomerania (SNiP) is a birth cohort study conducted Western Pomerania, Germany. SNiP-I recruited participants at between the years 2002 and 2008 (5801 inclusions). Since SNiP-I, population sociodemographic characteristics prevalence early exposures, including overweight gestational diabetes (GDM), have changed. To establish second (SNiP-II) same area as first sample (SNiP-I) decade later to investigate changes life exposures. Mothers with registered principal...

Abstract Background: Newborn screening (NBS) is an established procedure in many countries worldwide, aiming at the early detection of inborn errors metabolism. For decades, dried blood spots have been standard specimen for NBS. The collection well described and standardized includes critical pre-analytical steps. We examined impact contamination some anticipated common substances on NBS results obtained from dry spot samples. This possible source uncertainty has poorly past. Methods:...

Abstract Background Neonate immune cell functions lack full protection against pathogens. This could be either defect or protective mechanism overshooting proinflammatory responses. We here analysed the function of classical, pro- and anti-inflammatory monocytes granulocytes from neonates in comparison with adults to investigate if suppressed subpopulations are causative for unique neonatal status. Therefore, reactive oxygen species (ROS) surface activation markers were quantified...

Abstract Aim The aim was to investigate socio‐economic risk factors for maternal underweight before pregnancy and then associations of with neonatal outcomes. Methods Data 3401 mother‐child dyads from the population‐based birth cohort Survey Neonates in Pomerania (SNiP) were analysed. Results Bivariate analysis showed that underweighted mothers younger, smoked more often, had a lower equivalent income status (employment and/or educational level) compared women normal weight. final prediction...

<b>Background:</b> The shortage of skilled personnel is ubiquitous, basic and further training a key aspect in the recruitment new medical colleagues. significance nursing practicum its function as gateway to gynaecology obstetrics discipline practically unexplored. <b>Methods:</b> In an online questionnaire, students all German faculties were questioned about practica their courses. questionnaire reached 9079 students. 149 participants selectively asked answer 140 questions. We analysed...

Abstract Background Recent guidelines recommend a cranial ultrasound (CU) in neonates born at &lt; 30 weeks gestation, admitted to the neonatal intensive care unit (NICU), or with CU indication. Here, we addressed need extend these recommendations. Methods We retrospectively reviewed 5107 CUs acquired population-based Survey of Neonates Pomerania, conducted 2002 2008. conspicuous that were ≥ gestation without recent indications for identified and assigned following groups: (I) (II) admission...

The health status of newborns is a major concern for parents and medical personnel. Recent studies have provided increasing evidence that factors from the foetal perinatal periods life influence later in life. "Follow-up Survey Neonates Pomerania" (SNiP-I-Follow-up) first follow-up population-based birth cohort study, SNiP-I, established north-east Germany.The primary aim SNiP-I-Follow-up study was collection longitudinal data on children adolescents. associations will be analysed between...

Breastfeeding is a recognized preferred method of infant feeding; however, for many women, difficulties in breastfeeding result termination before the recommended period time. Acupuncture suggested to be promising option treat lactation insufficiency and enhance production maternal milk.We have reported case woman with due Caesarean section congenital unilateral invaginated nipple. Milk started on 3rd day following delivery. The newborn was not provided any food or fluids other than mother's...

Abstract Purpose The aim is to investigate the associations of mother’s socioeconomic and lifestyle factors life satisfaction with delivery a small for gestational age (SGA) infant. Methods Data from 4598 participants population-based birth cohort study Survey Neonates in Pomerania (SniP) including comprehensive information on pregnancies, mothers, their offspring Western Pomerania, Germany were used this study. analyzed using linear logistic regression models. Results After analysis...

The release of DNA by cells during extracellular trap (ET) formation is a defense function neutrophils and monocytes. Neutrophil ET (NET) in term infants reduced compared to adults. Objective: aim was quantify NET monocyte (MET) the respective key enzymes myeloperoxidase (MPO) neutrophil elastase (NE) preterm infants. In this prospective explorative study, induction stimulated N-formylmethionine-leucyl-phenylalanine (fMLP), phorbol 12-myristate 13-acetate (PMA), lipopolysaccharide (LPS),...

The German maternity guidelines require regular medical checkup (MC) during pregnancy as a measure of prevention. Socioeconomic factors such education, profession, income and origin, but also age parity may influence the preventive health behavior pregnant women. aim was to investigate these on participation rate in MC women.The current analysis is based prospective population-based birth cohort study Survey Neonates Pomerania, which conducted Western Germany. data 4092 women from 2004 2008...