A5069190627- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- dental development and anomalies
- Advanced X-ray Imaging Techniques
- Acne and Rosacea Treatments and Effects
- Urticaria and Related Conditions
- Ocular Infections and Treatments
- Facial Rejuvenation and Surgery Techniques
- Surfactants and Colloidal Systems
- Skin Protection and Aging
- Optical measurement and interference techniques
- Dermatology and Skin Diseases
- Retinal and Macular Surgery
- Retinal Imaging and Analysis
- melanin and skin pigmentation
- Connexins and lens biology
- Antimicrobial Peptides and Activities
- Contact Dermatitis and Allergies
- Advancements in Transdermal Drug Delivery
- Hedgehog Signaling Pathway Studies
- Syphilis Diagnosis and Treatment
Augenklinik Heidelberg
2009-2022
Ophthalmology Clinic
2017
Friedrich-Alexander-Universität Erlangen-Nürnberg
2012-2013
Orthopädische Praxis
2013
Universitätsklinikum Erlangen
2012
Berufsverband Niedergelassener Gynäkologischer Onkologen
2008
Klinikum Ludwigshafen
1992-2004
Although known for almost 80 years, the physiological role of plasmalogens (PLs), major mammalian ether lipids (ELs), is still enigmatic. Humans that lack ELs suffer from rhizomelic chondrodysplasia punctata (RCDP), a peroxisomal disorder usually resulting in death early childhood. In order to learn more about functions ELs, we generated mouse model RCDP by targeted disruption dihydroxyacetonephosphate acyltransferase gene. The mutant mice revealed multiple abnormalities, such as male...
Purpose: Evaporation of the tear film is heavily discussed as one core reason for dry eye disease (DED). Subsequently, new artificial products are developed that specifically target this pathomechanism. Perfluorohexyloctane (F6H8, NovaTears®) from family semifluorinated alkanes a novel substance has been approved medical device, nonblurring wetting agent ocular surface. Methods: Thirty patients with hyperevaporative received F6H8 during prospective, multicenter, observational 6-week study....
Meibomian gland disease is generally accepted as the leading cause for evaporative dry eye (DED). In a previous study, perfluorohexyloctane, semifluorinated alkane, has been demonstrated to significantly increase tear film breakup time and reduce corneal fluorescein staining in patients with DED, thereby vastly reducing eye-related symptoms. This study was set up evaluate perfluorohexyloctane larger population of dysfunction.Seventy-two associated received 1 drop 4 times daily during an...
Abstract: Meibomian gland dysfunction (MGD) is widespread and has significant impact on patients’ quality of life. Eyelid hygiene the mainstay treatment but unstandardized requires commitment from patient encouragement ophthalmologist. Blephasteam ® an eyelid warming device designed to be easy-to-use standardized for MGD. In present study, 73 patients were treated 21 days with twice daily sessions. The primary efficacy variable, a symptomatology visual analog scale score, declined...
Purpose: NovaTears®+Omega-3 is a water-free eye drop solution with non-animal-derived omega-3 fatty acids. It allows to supplement acids directly in the tear film of patients dry disease (DED). This post-market clinical follow-up (PMCF) study evaluated for first time effects on signs and patient symptoms DED, safety tolerability NovaTears+Omega-3 (0.2%) drops, when used accordance its approved label. Methods: A prospective, multicenter, single-arm, uncontrolled, open-label observational...
Objective:The aim was to evaluate the efficacy of Optive Plus ® , an artificial tear containing castor oil, in patients with dry eye, a routine clinical setting.Methods: This prospective, noninterventional study eye who switched from prior therapy or were naïve treatment (n=1,209).Patients issued tears.Dry severity, break-up time (TBUT), Schirmer score, Ocular Surface Disease Index (OSDI) and patient assessment symptoms recorded at baseline follow-up visit (4 weeks after starting ).Results:...
The factors and cellular interactions that influence the commitment of cells to specific neural lineages are not well understood. We have used cultured non-neuronal process-bearing (PB) from neonatal rat cerebral cortices as a model assess various culture conditions on determination either astroglia or oligodendroglia. Increasing postseparation plating density was significantly associated (p less than 0.001) with decreasing percentages glial fibrillary acidic protein (GFAP+) cells,...
X-linked hypohidrotic ectodermal dysplasia (XLHED) is the most common form of dysplasia. Clinical characteristics include meibomian gland disorder and resulting hyperevaporative dry eye. In this study, we evaluated meibography ocular infrared thermography as novel methods to diagnose XLHED.Eight infants, 12 boys 14 male adults with XLHED healthy control subjects were subjected a panel tests including surface disease index (OSDI), thermography, non-invasive measurement tear film break-up time...
This pooled analysis of two pivotal studies (ESSENCE-1 and ESSENCE-2) evaluated treatment effects a water-free ciclosporin 0.1% solution in dry eye disease (DED) patients the overall population subgroups according to sex, age, baseline severity disease. In these randomized, multicenter, double-masked, vehicle-controlled received or vehicle (1:1 ratio) both eyes twice daily for 85 29 days, respectively. Total central corneal fluorescein staining (tCFS; cCFS; NEI scale, 0–15) were assessed at...
sind zwei unterschiedliche Erkrankungen; können beide gemeinsam auftreten; ihre Beschwerden ähneln sich; überlappen sich in ihren diagnostischen Schritten; müssen unterschieden werden, um eine angemessene Behandlung durchführen zu können.
Anecdotal evidence suggests that eyelid disorders are common, although estimates of prevalence vary. The current study determines the disorders, meibomian gland dysfunction (MGD) and related diseases (specifically ocular surface disease) in a population patients presenting for routine ophthalmologic consultations.This cross-sectional epidemiologic survey evaluated ophthalmic visits. During consultation an ophthalmologist completed questionnaire, each patient underwent examination quality...
To investigate the impact of supplementation with a targeted micronutrient formulation on visual discomfort associated vitreous degeneration.In this clinical trial, 61 patients symptomatic floaters were randomized to consume daily, active supplement consisting 125 mg L-lysine, 40 vitamin C, 26.3 Vitis vinifera extract, 5 zinc, and 100 Citrus aurantium or placebo for 6 months. Change in from floaters, assessed Floater Disturbance Questionnaire, was primary outcome measure. Secondary measures...
Purpose: To investigate the efficacy, safety and tolerability of topical omega-3 polyunsaturated fatty acids (PUFA) as an innovative treatment dry eye disease (DED). Patients Methods: In a pilot, multicenter, masked-observer, randomized, active-controlled, non-inferiority study in Germany, patients self-treated their eyes with daily instillations drops containing either PUFA or povidone major components for three months. At four twelve weeks, efficacy was among others evaluated based on...
PURPOSE Effects of preservatives like benzalkonium chloride on the tear film are often hypothetized. With regard to Meibomian lipid layer only few data available. In order receive precise information about effect we performed in vitro experiments using a direct optical control films. METHODS gland secretion was spread water subphase containing concentrations 0.001%, 0.005%, 0.01%, 0.05%, and 0.1%, respectively. This aqueous chosen analogy layer. our experimental assay, pH 5.5, temperature 20...
Contrast thresholds under photopic and mesopic luminance conditions are compromised in subjects with vitreous degeneration. A plausible explanation is needed for the visual discomfort expressed by patients suffering from symptomatic degeneration.The current study investigates effect of degeneration on contrast at high spatial frequencies.An age-matched sample 115 subjects, comprising 30 floaters (cases) 85 healthy (controls), was included this study. Visual acuity flicker were measured all...