A5067032762- Infection Control in Healthcare
- Surgical site infection prevention
- Wound Healing and Treatments
- Medical Device Sterilization and Disinfection
- Plasma Applications and Diagnostics
- Antimicrobial agents and applications
- Infection Control and Ventilation
- Antimicrobial Resistance in Staphylococcus
- Surgical Sutures and Adhesives
- Nosocomial Infections in ICU
- Ocular Infections and Treatments
- Burn Injury Management and Outcomes
- Antibiotic Use and Resistance
- Oral microbiology and periodontitis research
- Thyroid Disorders and Treatments
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Health and Medical Studies
- Dental Research and COVID-19
- Bacterial Identification and Susceptibility Testing
- Medical Practices and Rehabilitation
- Medical and Health Sciences Research
- Orthopedic Infections and Treatments
- Contact Dermatitis and Allergies
- Pressure Ulcer Prevention and Management
Universitätsmedizin Greifswald
2016-2025
University of the Incarnate Word
2025
Bremen Institute for Applied Beam Technology
2024
Institut für Hygiene und Umwelt
2013-2023
Universität Greifswald
2009-2022
German Society of Surgery
2017-2022
Robert Koch Institute
2015-2022
Research Network (United States)
2021
ABB (Switzerland)
2010-2019
Heidelberg University
2017
To assess the suitability of an antiseptic agent, both microbicidal activity and cytotoxic effect must be taken into consideration to derive biocompatible antibacterial agents.We defined biocompatibility index (BI) by measuring against test organisms Escherichia coli Staphylococcus aureus and, in parallel, cytotoxicity on cultured murine fibroblasts. The agents tested were benzalkonium chloride (BAC), cetylpyridinium (CPC), chlorhexidine digluconate (CHX), mild silver protein (MSP),...
In the past years infections caused by multidrug-resistant Gram-negative bacteria have dramatically increased in all parts of world. This consensus paper is based on presentations, subsequent discussions and an appraisal current literature a panel international experts invited Rudolf Schülke Stiftung, Hamburg. It deals with epidemiology inherent properties bacteria, elucidating patterns spread antibiotic resistance, highlighting reservoirs as well transmission pathways risk factors for...
BackgroundThis study presents a comparative investigation of the antimicrobial efficacy antiseptics PVP–iodine, triclosan, chlorhexidine, octenidine and polyhexanide used for pre-surgical antisepsis antiseptic treatment skin, wounds mucous membranes based on internationally accepted standards.
Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and spread multidrug-resistant organisms (MDROs). However, strict indication must be set for application these agents. An infected or critically colonized wound treated antiseptically. In addition, systemic antibiotic therapy is required in case infection spreads. If applied preventively, Wounds-at-Risk Score allows an assessment risk thus appropriateness indication....
The rate of microscopic incomplete resections gastrointestinal cancers including pancreatic cancer has not changed considerably over the past years. Future intra-operative applications tissue tolerable plasmas (TTP) could help to address this problem. Plasma is generated by feeding energy, like electrical discharges, gases. development non-thermal atmospheric displaying spectra temperature within or just above physiological ranges allows biological medical plasmas. We have investigated...
Plasma medicine is an interdisciplinary field and recent clinical studies showed benefits of topical plasma application to chronic wounds. Whereas most investigations have focused on plasma-skin cell interaction, immune cells are omnipresent in tissues as well. They not only elicit specific responses but also regulate inflammation, which central healing regeneration. generates short-lived radicals species the gas phase. Mechanisms plasma-cell interactions fully understood it hypothesized...
Objective: The aim of the present study was to analyze current status morphologic and functional thyroid abnormalities in a previously iodine-deficient area. Methods: population based Study Health Pomerania (SHIP) comprised 4310 participants, aged 20-79 years. Thyroid function (thyrotropin [TSH] free triiodothyronine [FT3], thyroxine [FT4]) serum autoantibodies thyroperoxidase (TPOAb) were evaluated from blood samples. structure size measured by ultrasound. Data 3941 participants with no...
The medical use of non-thermal physical plasmas is intensively investigated for sterilization and surface modification biomedical materials. A further promising application the removal or etching organic substances, e.g., biofilms, from surfaces, because remnants biofilms after conventional cleaning procedures are capable to entertain inflammatory processes in adjacent tissues. In general, contamination surfaces by micro-organisms a major source problems health care. Especially most common...
In recent years, extended-spectrum β-lactamases (ESBL) producing bacteria have been found in livestock, mainly as asymptomatic colonizers. The zoonotic risk for people working close contact to animal husbandry has still not completely assessed. Therefore, we investigated the prevalence of ESBL-producing Escherichia spp. livestock animals and workers determine potential an animal-human cross-transmission.In Mecklenburg-Western Pomerania, northeast Germany, inguinal swabs 73 individuals with...
Objective: In the age of multiresistant microbes and increasing lack efficient antibiotics, conventional antiseptics play a critical role in prevention therapy wound infections. Recent studies have demonstrated antiseptic effects cold atmospheric pressure plasma (APP). this pilot, study we investigate overall suitability one first APP sources for treatment focusing on its potential antimicrobial effects. Method: The closure rate bacterial colonisation wounds were investigated. Patients...
Koban I, Holtfreter B, Hübner N-O, Matthes R, Sietmann Kindel E, Weltmann K-D, Welk A, Kramer Kocher T. Antimicrobial efficacy of non-thermal plasma in comparison to chlorhexidine against dental biofilms on titanium discs vitro – proof principle experiment. J Clin Periodontol 2011; 38: 956–965. doi: 10.1111/j.1600-051X.2011.01740.x. Abstract Aim: Dental play a major role the pathogenesis peri-implant mucositis. Biofilm reduction is pre-requisite for successful therapy mucosal lesions. In...
Health care associated infections, the fourth leading cause of disease in industrialised countries, are a major health issue. One part this condition is based on increasing insertion and implantation prosthetic medical devices, since presence foreign body significantly reduces number bacteria required to produce infection. The most significant hospital-acquired frequency potential severity, those related procedures e.g. surgical site infections including urinary tract infection catheterized...
Because of some disadvantages chemical disinfection in dental practice (especially denture cleaning), we investigated the effects physical methods on Candida albicans biofilms. For this purpose, antifungal efficacy three different low-temperature plasma devices (an atmospheric pressure jet and two dielectric barrier discharges (DBDs)) biofilms grown titanium discs vitro was investigated. As positive treatment controls, used 0.1% chlorhexidine digluconate (CHX) 0.6% sodium hypochlorite...
One of the promising possibilities clinical application cold plasma, so-called atmospheric plasma (CAP), is its on malignant cells and cancer tissue using anti-neoplastic effects, primarily through delivery reactive oxygen nitrogen species (ROS, RNS). In this study, we investigated impact CAP cellular proliferation consecutive molecular response mechanisms in established prostate (PC) cell lines. PC showed a significantly reduced growth following treatment as result both an immediate...
Abstract Background Antibiotic-resistant Klebsiella pneumoniae are a major cause of hospital- and community-acquired infections, including sepsis, liver abscess, pneumonia, driven mainly by the emergence successful high-risk clonal lineages. The K. sequence type (ST) 307 lineage has appeared in several different parts world after first being described Europe 2008. From June to October 2019, we recorded an outbreak extensively drug-resistant ST307 four medical facilities north-eastern...
Objective So-called cold physical plasmas for biomedical applications generate reactive oxygen and nitrogen species the latter can trigger DNA damage at high concentrations. Therefore, mutagenic risks of a certified atmospheric pressure argon plasma jet (kINPen MED) its predecessor model 09) were assessed. Methods Inner egg membranes fertilized chicken eggs received single treatment with either kINPen 09 (1.5, 2.0, or 2.5 min) MED (3, 4, 5, 10 min). After three days incubation, blood smears...
Multiresistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) cause serious postoperative infections. A skin tolerant far-UVC (< 240 nm) irradiation system for their inactivation is presented here. It uses UVC LEDs in combination with a spectral filter and provides peak wavelength of 233 nm, full width at half maximum 12 an irradiance 44 µW/cm
Abstract Healthcare-associated infections (HAIs) and antimicrobial resistance (AMR) pose threats to global health. Effective hand hygiene is essential for preventing HAIs the spread of AMR in healthcare. We aimed highlight recent progress future directions alcohol-based handrub (ABHR) use healthcare setting. In September 2023, 42 experts infection prevention control (IPC) convened at 3rd International Conference on Prevention Infection Control (ICPIC) ABHR Taskforce Geneva, Switzerland. The...