A5034822565- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Neutropenia and Cancer Infections
- Plant Pathogens and Fungal Diseases
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Mycology
- COVID-19 and healthcare impacts
- Viral gastroenteritis research and epidemiology
- Vaccine Coverage and Hesitancy
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 and Mental Health
- Cardiac, Anesthesia and Surgical Outcomes
- Indoor Air Quality and Microbial Exposure
- Surgical site infection prevention
- Influenza Virus Research Studies
- Bacterial Identification and Susceptibility Testing
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immunodeficiency and Autoimmune Disorders
- Nail Diseases and Treatments
- Asthma and respiratory diseases
German Center for Infection Research
2019-2025
University of Cologne
2019-2025
University Hospital Cologne
2019-2025
Heinrich Heine University Düsseldorf
2019-2025
Düsseldorf University Hospital
2019-2025
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2019-2025
Integrated Oncology (United States)
2024
Centrum für Integrierte Onkologie
2023
Pneumonia caused by severe acute respiratory syndrome coronavirus 2 emerged in China at the end of 2019. Because immunomodulation and lymphocyte depletion this virus subsequent administration drugs directed immune system, we anticipated that patients might experience fungal superinfection. We collected data from 186 who had disease-associated pulmonary aspergillosis (CAPA) worldwide during March-August 2020. Overall, 182 were admitted to intensive care unit (ICU), including 180 with distress...
Prolonged shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been observed in immunocompromised hosts. Early monotherapy with direct-acting antivirals or monoclonal antibodies, as recommended by the international guidelines, does not prevent this certainty. Dual therapies may therefore have a synergistic effect.
Abstract Background Midostaurin is a multikinase inhibitor for the treatment of Fms-like tyrosine 3 (FLT3)-mutated acute myeloid leukaemia (AML). Cardiac adverse events like QTc-prolongation, pericardial effusion, and congestive heart failure have been described. Inflammatory diseases associated with midostaurin are rarely reported. Case summary A 24-year-old man newly diagnosed AML FLT3-ITD mutation was treated intensive remission-induction chemotherapy midostaurin. After 5 days...
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SARS-CoV-2 neutralising antibodies provide protection against COVID-19. Evidence from early vaccine trials suggested binding antibody thresholds could serve as surrogate markers of capacity, but whether these predict sufficient capacity variants concern (VOCs), and this is impacted by or infection history remains unclear. Here we analyse individuals recovered from, vaccinated with hybrid immunity SARS-CoV-2. An NT50 ≥ 100 IU confers in trials, however, VOC induce a reduction NT50, use 1000...
Abstract Background We assessed the laboratory diagnosis and treatment of invasive fungal disease (IFD) in Italy to detect limitations potential for improvement. Methods The survey was available online at www.clinicalsurveys.net/uc/IFI management capacity/, collected variables such as (a) institution profile, (b) perceptions IFD respective institution, (c) microscopy, (d) culture identification, (e) serology, (f) antigen detection, (g) molecular tests, (h) susceptibility testing (i)...
Abstract Introduction Immunosuppression after chemotherapy, stem cell transplantation or solid organ are the main risk factors for invasive fungal infections in Austria. Here, we aim to describe status of laboratory mycology and access antifungal treatment Methods Between October November 2021, hospitals were contacted participate our online survey: www.clinicalsurveys.net/uc/IFI_management_capacity/ . Centres required provide information on their institutional profile; self‐assessment...
Abstract Introduction In Germany, the growing incidence of invasive fungal infections (IFIs) is a significant health concern, particularly impacting individuals with compromised immune systems due to factors like increasing transplant recipients, an ageing population, and heightened use immunosuppressive medications. Diagnosing IFI remains challenging, integration biomarker assays into clinical practice difficult. Antifungal resistance, exemplified by pan-antifungal-resistant Candida auris...
Abstract Background Surgical site infections (SSI), mainly caused by Staphylococcus aureus, represent a significant economic burden in Europe, leading to an increase length of hospitalization, mortality and treatment costs, especially with drug-resistant strains. such as methicillin-resistant aureus. A new case-control study high-volume centers aims provide detailed data on the impact treating aureus SSIs. Methods The SALT is multinational retrospective cohort analysis focused SSIs Europe....
ABSTRACT Background Invasive mould infections (IMI) cause substantial morbidity and mortality in populations at risk. Novel treatment approaches are urgently needed. Targeting immune checkpoints may reverse hyporesponsiveness of the innate adaptive systems. Methods In this prospective, observational study, we investigated checkpoint expression levels on cells patients with invasive aspergillosis (IA; n = 25) mucormycosis (MU; 7). Healthy controls (HC; 5) matched haematological diseases but...