A5062723924- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- HIV-related health complications and treatments
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Bone and Joint Diseases
- SARS-CoV-2 detection and testing
- Hepatitis C virus research
- COVID-19 and Mental Health
- HIV/AIDS Research and Interventions
- Intensive Care Unit Cognitive Disorders
- Gut microbiota and health
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Sepsis Diagnosis and Treatment
- Bacillus and Francisella bacterial research
- Immunotherapy and Immune Responses
- Disaster Response and Management
- Inflammatory Biomarkers in Disease Prognosis
- Palliative Care and End-of-Life Issues
- Poxvirus research and outbreaks
- Ultrasound in Clinical Applications
- Fibromyalgia and Chronic Fatigue Syndrome Research
Mater Misericordiae University Hospital
2016-2025
University College Dublin
2016-2025
Université Paris Cité
2025
Global Virus Network
2020
St. Vincent's University Hospital
2017-2020
University College London
2014-2017
University of Zimbabwe
2017
St. James's Hospital
2016
The Royal Free Hospital
2014
GTx (United States)
2011
Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory Syndrome 2 (SARS-CoV-2), has affected over 30 million globally to date. Although high rates of venous thromboembolism and evidence COVID-19-induced endothelial dysfunction have been reported, precise aetiology increased thrombotic risk associated with COVID-19 infection remains be fully elucidated. Therefore, we assessed clinical platelet parameters circulating activity in patients severe nonsevere COVID-19. An...
We aimed to describe the clinical presentation of individuals presenting with prolonged recovery from coronavirus disease 2019 (COVID-19), known as long COVID.This was an analysis within a multicenter, prospective cohort study confirmed diagnosis COVID-19 and persistent symptoms >4 weeks onset acute symptoms. performed multiple correspondence (MCA) on most common self-reported hierarchical clustering results MCA identify symptom clusters.Two hundred thirty-three were included in analysis;...
Abstract Background The European AIDS Clinical Society (EACS) Guidelines were revised in 2021 for the 17th time with updates on all aspects of HIV care. Key points update Version 11.0 recommend six first‐line treatment options antiretroviral (ART)‐naïve adults: tenofovir‐based backbone plus an unboosted integrase inhibitor or doravirine; abacavir/lamivudine dolutegravir; dual therapy lamivudine emtricitabine dolutegravir. Recommendations preferred and alternative combinations from birth to...
Current or recent use of abacavir for treating human immunodeficiency virus type 1 (HIV-1) infection has been associated with increased rates myocardial infarction (MI). Given the role platelet aggregation in thrombus formation MI and reversible nature association, we hypothesized that patients treated would have reactivity.In a prospective study adult HIV-infected patients, determined associations between antiretrovirals (ARVs), particular nucleoside reverse transcriptase inhibitor...
Low bone mineral density (BMD) is common in HIV-positive patients, although the role played by HIV infection versus sociodemographic and metabolic factors remains unclear.Understanding Pathology of Bone Disease HIV-infected individuals (HIV UPBEAT) a prospective cohort study, enrolled HIV-negative participants from similar demographic backgrounds. Dual X-ray absorptiometry at femoral neck, total hip lumbar spine blood tests were performed. Associations between BMD interest assessed using...
Background: Whilst reporting improved renal and bone safety profiles, studies have noted changes in lipid profiles among people living with HIV (PLWH) receiving antiretroviral therapy (ART) switching away from tenofovir disoproxil fumarate (TDF) to alafenamide (TAF). We aimed characterize lipids observed after TAF-containing ART a real-world setting. Methods: A prospective study on PLWH enrolled the UCD-ID Cohort who switched ART. Routine laboratory data [including (total cholesterol (TC),...
BackgroundFew studies to date have explored the health-related quality of life (HRQoL) in patients with long COVID.MethodsThe Anticipate Study is a prospective single-centre observational cohort study. Hospitalised and nonhospitalised were seen at dedicated post-COVID clinic 2-4 month (Timepoint 1) 7-14 follow-up 2). The main objectives this study are assess longitudinal impact COVID-19 using 12-item Short Form Survey (SF-12) score, tool, identify predictors developing post–COVID-19 syndrome...
SARS-CoV-2 neutralising antibodies provide protection against COVID-19. Evidence from early vaccine trials suggested binding antibody thresholds could serve as surrogate markers of capacity, but whether these predict sufficient capacity variants concern (VOCs), and this is impacted by or infection history remains unclear. Here we analyse individuals recovered from, vaccinated with hybrid immunity SARS-CoV-2. An NT50 ≥ 100 IU confers in trials, however, VOC induce a reduction NT50, use 1000...
Abstract Background The global mpox outbreak which started in May 2022 was caused by a novel clade IIb variant of the virus (MPXV). It differed from traditional Western and Central Africa disease transmission patterns clinical presentation. Methods To address need for detailed virologic data, we conducted an observational cohort study (MOSAIC) during 2022-July 2023 individuals with confirmed MPXV infection enrolled six European Countries. Case-management decisions were left to attending...
Abstract Background Inflammation and innate immune activation are associated with chronic HIV infection, despite effective treatment. Although gut microbiota alterations linked to systemic inflammation, the relationships between microbiome, inflammation remain unclear. Methods The UPBEAT-CAD sub-study, examining cardiovascular disease (CVD) risk in HIV, enrolled participants matched on status traditional CVD factors. Subclinical was assessed using coronary computed tomography angiography...
Abstract Patient and public involvement engagement (PPIE) in health care research has been advocated to ensure that the is relevant, acceptable beneficial communities it serves. However, there remains a significant gap projects incorporating PPIE among transgender communities, particularly from global South. In this narrative summary authors describe methodology of through novel collaboration with community members for design development bilingual culturally sensitive educational...
Cardiovascular disease and myocardial infarction are of increasing concern in HIV-infected populations. Although platelets mediate arterial thrombosis, central to infarction, data on platelet function HIV infection lacking. We hypothesized that patients would have altered reactivity.A case-control study reactivity 20 (HIVpos) age sex-matched HIV-negative (HIVneg) individuals.Time-dependent aggregation was measured response concentrations agonists: epinephrine, collagen, thrombin...
In virologically suppressed, antiretroviral-treated patients, the effect of switching to tenofovir (TDF) on bone biomarkers compared patients remaining stable antiretroviral therapy is unknown.We examined (osteocalcin [OC], procollagen type 1 amino-terminal propeptide, and C-terminal cross-linking telopeptide collagen) mineral density (BMD) over 48 weeks in suppressed (HIV RNA < 50 copies/ml) randomized switch TDF/emtricitabine (FTC) or remain first-line zidovudine (AZT)/lamivudine (3TC)....
Objectives Studies suggest 2 per 1000 people in Dublin are living with HIV, the level above which universal screening is advised. We aimed to assess feasibility and acceptability of a opt-out Hepatitis B C testing programme for Emergency Department patients describe incidence prevalence blood-borne viruses this population. Methods An ED blood borne virus was piloted from March 2014 January 2015. Patients undergoing sampling during routine clinical care were offered HIV 1&2 antibody/antigen...
Objective: Although low bone mineral density (BMD) is prevalent in HIV, changes BMD over time remain unclear. We aimed to compare rates of, and factors associated with, change between HIV-positive HIV-negative patients. Methods: In a prospective, 3-year cohort, patients provided annual demographic clinical data, fasting bloods, dual x-ray absorptiometry. Using longitudinal mixed models we compared determined predictors of rate BMD. Results: Of 384 study participants (45.8% HIV positive), 120...
To date, coronavirus disease 2019 (COVID-19) has affected over 100 million people globally. COVID-19 can present with a variety of different symptoms leading to manifestation ranging from mild cases life-threatening condition requiring critical care-level support. At present, rapid prediction severity and care requirement in patients, early stages disease, remains an unmet challenge. Therefore, we assessed whether parameters routine clinical hematology workup, at the time hospital admission,...
Background Dysregulated immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are thought underlie the progression of disease 2019 (COVID-19) disease. We sought determine whether early host immune-related gene expression could predict clinical Methods analysed 579 immunological genes in peripheral blood mononuclear cells taken after symptom onset using NanoString nCounter and compared SARS-CoV-2 negative controls with positive subjects mild (SARS+ Mild)...
Abstract Background Defining patterns of symptoms in long COVID is necessary to advance therapies for this heterogeneous condition. Here we aimed describe clusters individuals with and explore the impact emergence variants concern (VOCs) vaccination on these clusters. Methods In a prospective, multi centre cohort study, persisting > 4 weeks from acute COVID-19 were divided into two groups based timing infection; pre-Alpha VOC, denoted wild type (WT) group post-Alpha VOC (incorporating...
Introduction A clear immune correlate of protection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has not been defined. We explored antibody, B-cell, and T-cell responses to the third-dose vaccine relationship incident SARS-CoV-2 infection. Methods Adults in a prospective cohort provided blood samples at day 0, 14, 10 months after vaccine. Participants self-reported Plasma anti–SARS-CoV-2 receptor-binding domain (RBD) spike-subunit-1 spike-subunit-2 antibodies...