Colm Bergin
A5079611632- COVID-19 Clinical Research Studies
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- HIV-related health complications and treatments
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver Disease Diagnosis and Treatment
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Intensive Care Unit Cognitive Disorders
- Cervical Cancer and HPV Research
- COVID-19 and Mental Health
- Innovations in Medical Education
- HIV/AIDS oral health manifestations
- Syphilis Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Drug-Induced Adverse Reactions
- Immune Cell Function and Interaction
St. James's Hospital
2016-2025
Trinity College Dublin
2016-2025
University Hospitals Birmingham NHS Foundation Trust
2024
Infectious Disease Consultants
2024
St. Vincent's University Hospital
2024
University of Toronto
2021
Spanish Oncology Genitourinary Group
2006-2021
Gujarat Institute of Desert Ecology
2021
ProQuest (United States)
2019
Australia and New Zealand Banking Group
2019
Fatigue is a common symptom in those presenting with symptomatic COVID-19 infection. However, it unknown if results persistent fatigue recovered from acute We examined the prevalence of individuals phase illness using Chalder Score (CFQ-11). further potential predictors following infection, evaluating indicators severity, markers peripheral immune activation and circulating pro-inflammatory cytokines. Of 128 participants (49.5 ± 15 years; 54% female), more than half reported (67/128; 52.3%)...
Introduction A panel of experts met in Paris on 18 April to present research and practice protocols, discuss topics current interest related the treatment HIV/hepatitis C virus (HCV) co-infection. The information presented focussed following main aspects: magnitude problem HIV/HCV co-infection differences similarities between HIV HCV disease paradigms, thereby allowing extrapolation lessons learned care patients with or co-infections Strategies for managing HCV-co-infected using...
Although the pathophysiology underlying severe COVID19 remains poorly understood, accumulating data suggest that a lung-centric coagulopathy may play an important role. Elevated D-dimer levels which correlated inversely with overall survival were recently reported in Chinese cohort studies. Critically however, ethnicity has major effects on thrombotic risk, 3-4-fold lower risk compared to Caucasians and significantly higher African-Americans. In this study, we investigated Caucasian...
Rationale: Much is known about the acute infective process of severe respiratory syndrome coronavirus 2 (SARS-CoV-2), causative virus disease (COVID-19) pandemic. The marked inflammatory response and coagulopathic state in SARS-CoV-2 infection may promote pulmonary fibrosis. However, little incidence seriousness post–COVID-19 pathology. Objectives: To describe recovery self-reported health after at time outpatient attendance. Methods: Infection severity was graded into three groups: 1) not...
BackgroundPersistent fatigue, breathlessness, and reduced exercise tolerance have been reported following acute COVID‐19 infection. Although immuno‐thrombosis has implicated in pathogenesis, the biological mechanisms underpinning long COVID remain unknown. We hypothesized that pulmonary microvascular may be important this context.MethodsOne hundred fifty patients were reviewed at St James's Hospital Dublin between May September 2020 a median of 80.5 (range 44–155) days after initial...
Our aim was to describe episodic nature of disability among adults living with Long COVID.We conducted a community-engaged qualitative descriptive study involving online semistructured interviews and participant visual illustrations. We recruited participants via collaborator community organisations in Canada, Ireland, UK USA.We who self-identified as COVID diversity age, gender, race/ethnicity, sexual orientation duration since initial infection between December 2021 May 2022. used...
Many practical clinical questions regarding the management of human immunodeficiency virus (HIV)–associated neurocognitive disorder (HAND) remain unanswered. We sought to identify and develop answers key in HAND management. Sixty-six specialists from 30 countries provided input into program, which was overseen by a steering committee. Fourteen were rated as being greatest importance. Answers drafted an expert group based on comprehensive literature review. Sixty-three experts convened...
Morbidity and mortality attributable to chronic hepatitis C virus (HCV) infection are increasing in many countries as the infected population ages. Models were developed for 15 quantify characterize viremic population, well estimate number of new infections HCV related deaths from 2013 2030. Expert consensus was used determine current treatment levels outcomes each country. In most countries, prevalence has already peaked. every country studied, begins decline before 2030, when held...
Summary Endothelial cell (EC) activation plays a key role in the pathogenesis of pulmonary microvascular occlusion, which is hallmark severe coronavirus disease 2019 (COVID‐19). Consistent with EC activation, increased plasma von Willebrand factor antigen (VWF:Ag) levels have been reported COVID‐19. Importantly however, studies other microangiopathies shown that VWF propeptide (VWFpp) more sensitive and specific measure acute activation. In present study, we further investigated nature...
Summary Chronic hepatitis C virus ( HCV ) infection is a leading cause of liver related morbidity and mortality. In many countries, there lack comprehensive epidemiological data that are crucial in implementing disease control measures as new treatment options become available. Published literature, unpublished expert consensus were used to determine key parameters, including prevalence, viremia, genotype the number patients diagnosed treated. this study 15 viremic prevalence ranged from...
High quality clinical learning environments (CLE) are critical to postgraduate medical education (PGME). The understaffed and overcrowded in which many residents work present a significant challenge learning. purpose of this study was develop national expert group consensus amongst stakeholders PGME to; (i) identify important barriers facilitators CLEs (ii) indicate priority areas for improvement. Our objective provide information focus efforts high CLEs. Group Concept Mapping (GCM) is an...
Considering the chronic and debilitating nature of HIV infection, health-related quality life (HRQoL) is an important patient-reported clinical outcome to better understand effects this infection its treatment on patients' lives. The purpose study was assess HRQoL association with sociodemographic, behavioural, clinical, nutrition-related factors social support in Irish cohort. A cross-sectional, prospective using Medical Outcomes Study Health survey assessed 10 dimensions summarised as...
Background The long-term clinical and physiological consequences of COVID-19 infection remain unclear. While fatigue has emerged as a common symptom following infection, little is known about its links with autonomic dysfunction. SARS-CoV-2 to infect endothelial cells in acute resulting Here we set out test the hypothesis that this results persistent dysfunction associated post-COVID convalescent patients. Methods We recruited 20 fatigued non-fatigued patients (median age 44.5 years, 36/40...
Bacterial respiratory coinfection in the setting of SARS-CoV-2 infection remains poorly described. A description and antimicrobial usage is needed to guide ongoing stewardship.To assess rate empirical treatment COVID-19 cases, methods microbiological sampling, bacterial coinfections evaluate factors associated with therapy this cohort.Inpatients positive PCR were recruited. Antibiotic prescription, choice duration recorded. Taking samples (sputum culture, blood urinary antigens) culture...
BackgroundConsistent with fulminant endothelial cell activation, elevated plasma von Willebrand factor (VWF) antigen levels have been reported in patients COVID‐19. The multimeric size and function of VWF are normally regulated through A Disintegrin And Metalloprotease ThrombSpondin Motif type 1 motif, member 13 (ADAMTS‐13)‐‐mediated proteolysis.ObjectivesThis study investigated the hypothesis that ADAMTS‐13 regulation multimer distribution may be impaired severe acute respiratory...
BackgroundProlonged recovery is common after acute SARS-CoV-2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown. VWF/ADAMTS-13 imbalance, dysregulated angiogenesis, and immunothrombosis are hallmarks of COVID-19. We hypothesized that imbalance persists in convalescence together with endothelial cell (EC) activation angiogenic disturbance. Additionally, we postulate ongoing immune dysfunction may be linked to sustained EC coagulation...
Abstract Objective: To demonstrate the effectiveness of Charlson weighted index comorbidity (WIC) for controlling in prospective studies focusing on mortality patients with Staphylococcus aureus bacteremia (SAB). Design: Cohort study. Setting: Two tertiary-care, university-affiliated hospitals France. Patients: One hundred sixty-six inpatients 18 years or older consecutively diagnosed SAB from May 15, 2001, to 2002. Methods: Patients were prospectively assessed and cases followed by...
Abstract Fatigue is a common symptom in those presenting with symptomatic COVID-19 infection. However, it unknown if results persistent fatigue recovered from acute We examined the prevalence of individuals phase illness using Chalder Score (CFQ-11). further potential predictors following infection, evaluating indicators severity, markers peripheral immune activation and circulating pro-inflammatory cytokines. Of 128 participants (49.5 ± 15 years; 54% female), more than half reported (52.3%;...
Objectives The immunological and inflammatory changes following acute COVID-19 are hugely variable. Persistent clinical symptoms resolution of initial infection, termed long COVID , also variable, but association with has not been described. We investigate changing parameters in convalescent interrogate their potential relationships persistent symptoms. Methods performed paired immunophenotyping at SARS-CoV-2 infection convalescence (n=40, median 68 days) validated findings 71 further...