Moshe Leshno

ORCID: 0000-0003-1485-0623
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About
Contact & Profiles
Research Areas
  • Health Systems, Economic Evaluations, Quality of Life
  • Liver Disease Diagnosis and Treatment
  • Gastric Cancer Management and Outcomes
  • Electronic Health Records Systems
  • Colorectal Cancer Screening and Detection
  • Food Allergy and Anaphylaxis Research
  • Hepatitis C virus research
  • Helicobacter pylori-related gastroenterology studies
  • Inflammatory Bowel Disease
  • Genetic factors in colorectal cancer
  • Economic and Financial Impacts of Cancer
  • Microscopic Colitis
  • Hepatitis B Virus Studies
  • Cancer Immunotherapy and Biomarkers
  • Medical Coding and Health Information
  • Eosinophilic Esophagitis
  • Healthcare Systems and Technology
  • Neural Networks and Applications
  • Pancreatic and Hepatic Oncology Research
  • Blood Pressure and Hypertension Studies
  • Renal cell carcinoma treatment
  • Healthcare Policy and Management
  • Celiac Disease Research and Management
  • Liver Disease and Transplantation
  • Healthcare cost, quality, practices

Tel Aviv University
2016-2025

Academic College of Tel Aviv-Yafo
2024

Tel Aviv Sourasky Medical Center
2006-2023

St. Raphael's Hospital
2021

Goldman Sachs (United States)
2021

Assaf Harofeh Medical Center
2016

Ono Academic College
2012

Clalit Health Services
2007

Rabin Medical Center
2007

University Gastroenterology
2006

Background: Guaiac-based fecal occult blood tests (FOBTs) for colorectal cancer screening are not specific human hemoglobin and have low sensitivity. Automated-development, immunochemical FOBT is quality-controlled, hemoglobin, does require diet restriction. Objectives: To measure the sensitivity specificity of quantitative measurements detection advanced adenoma in patients undergoing colonoscopy, to determine thresholds that give highest posttest probability neoplasia, number FOBTs needed....

10.7326/0003-4819-146-4-200702200-00003 article EN Annals of Internal Medicine 2007-02-20

While “most” decision makers may prefer one uncertain prospect over another, stochastic dominance rules as well other investment criteria, will not reveal this preference due to some extreme utility functions in the case of even a very small violation these rules. Such strict relate “all” given class including ones which presumably rarely represents investors' preference. In paper we establish almost (ASD) formally for makers, but them. The ASD that choices probably conform with also solve...

10.1287/mnsc.48.8.1074.169 article EN Management Science 2002-08-01

BACKGROUND The role of screening colonoscopy for colorectal (CR) neoplasia in average-risk population, remains to be determined. OBJECTIVES To evaluate the prevalence and anatomic location CR adenoma carcinoma morbidity individuals at average risk cancer (CRC). METHODS A retrospective study subjects aged 40–80 yr, with no cancer-related symptoms, personal or family history neoplasia, who underwent a colonoscopy. RESULTS Enrolled were 1,177 persons; 183 40–49 yr (young), 917 50–75 77 76–80...

10.1111/j.1572-0241.2006.00430.x article EN The American Journal of Gastroenterology 2006-02-01

Morbidity and mortality attributable to chronic hepatitis C virus (HCV) infection are increasing in many countries as the infected population ages. Models were developed for 15 quantify characterize viremic population, well estimate number of new infections HCV related deaths from 2013 2030. Expert consensus was used determine current treatment levels outcomes each country. In most countries, prevalence has already peaked. every country studied, begins decline before 2030, when held...

10.1111/jvh.12351 article EN Journal of Viral Hepatitis 2015-01-01

Summary Chronic hepatitis C virus ( HCV ) infection is a leading cause of liver related morbidity and mortality. In many countries, there lack comprehensive epidemiological data that are crucial in implementing disease control measures as new treatment options become available. Published literature, unpublished expert consensus were used to determine key parameters, including prevalence, viremia, genotype the number patients diagnosed treated. this study 15 viremic prevalence ranged from...

10.1111/jvh.12350 article EN Journal of Viral Hepatitis 2015-01-01

Abstract: Background: The upper normal limit (ULN) of serum alanine‐aminotrasferase (ALT) range was recently challenged, because patients diagnosed with liver diseases may have ‘normal’ or near‐‘normal’ ALT levels, and possible modulators are often ignored in determining range. Aim: To estimate the ULN for to identify factors modulating it. Subjects methods: We reviewed medical records subjects aged 15–90, who underwent standard panels laboratory tests, including ALT, over 6 months at a...

10.1111/j.1478-3231.2006.01197.x article EN Liver International 2006-04-10

Abstract Background Isolated rectal bleeding in infants is often attributed to the consumption of cow's milk. However, prevalence this condition has not been described, and its preferred diagnostic methods management are controversial. Methods In a prospective population‐based study following 13,019 children from birth, 21 with isolated milk protein were identified. Following evaluation, parents encouraged resume followed for reappearance symptoms thereafter 6 yr. addition, compared control...

10.1111/pai.12009 article EN Pediatric Allergy and Immunology 2012-10-11

In October 2016, pembrolizumab became the new standard of care for firstline treatment patients with metastatic non-small cell lung cancer (mNSCLC) whose tumors express programmed death ligand 1 in at least 50% cells. The US Food and Drug Administration-recommended dose is 200 mg every three weeks. Multiple studies have demonstrated equivalent efficacy weight-based doses between 2 mg/kg 10 mg/kg. objective this study was to compare economic impact using personalized dosing (2 mg/kg) vs fixed...

10.1093/jnci/djx063 article EN JNCI Journal of the National Cancer Institute 2017-03-16

Many medical organizations have invested heavily in electronic health record (EHR) and information exchange (HIE) systems (IS) to improve decision-making increase efficiency. Despite the potential interoperability advantages of such IS, physicians do not always immediately consult information, this decision may result decreased level quality care as well unnecessary costs. This study sought reveal effect EHR IS use on physicians' admission decisions. It was hypothesizing using will more...

10.1186/1472-6947-13-49 article EN cc-by BMC Medical Informatics and Decision Making 2013-04-17

Liver steatosis may occur concomitantly in patients with chronic hepatitis B infection (CHB) and is implicated increased morbidity mortality. Hepatitis virus (HBV) viral load a marker for disease progression long-term outcomes CHB. We investigated the association between liver HBV their individual effects on all-cause mortality development of cancer CHB steatosis.This retrospective study included 524 treatment-naïve CHB, mean follow-up 6 years. biopsy was available 170 validated by at least...

10.1016/j.jhepr.2019.02.002 article EN cc-by-nc-nd JHEP Reports 2019-03-27

Sesame food allergy (SFA) in children is an increasingly recognized one many countries. Our objective was to describe the course and natural history of SFA. Seventy‐four patients sensitized sesame were evaluated using clinical records, questionnaires, skin prick tests (SPT), vitro specific immunoglobulin (sIg) E, oral challenges (OC) categorized into three groups: group A: who experienced allergic reaction after ingestion sesame‐containing (n = 45); B: for atopic dermatitis found be...

10.1111/j.1399-3038.2006.00506.x article EN Pediatric Allergy and Immunology 2007-03-07

Background.Pseudomonas aeruginosa is an uncommon cause of community-acquired bacteremia among patients without severe immunodeficiency. Because tension exists between the need to limit unnecessary use anti-pseudomonal agents and avoid a delay in appropriate therapy, clinicians require better guidance regarding when cover empirically for P. aeruginosa. We sought determine occurrence construct model predict upon hospital admission. Methods. A retrospective study was conducted 4 tertiary care...

10.1086/596709 article EN Clinical Infectious Diseases 2009-01-20

Modern immuno-oncology agents have generated great excitement because of their potential to provide durable survival for some patients. However, there is concern regarding the cost cancer care, and multiple frameworks been developed assess value. The American Society Clinical Oncology (ASCO) framework awards bonus points if substantial demonstrated.To whether modern reach defined efficacy thresholds in value frameworks.In this analysis, all US Food Drug Administration (FDA) approvals between...

10.1001/jamaoncol.2017.4445 article EN JAMA Oncology 2017-12-28
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