A5007517961- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Blood groups and transfusion
- Hemophilia Treatment and Research
- Complement system in diseases
- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 Clinical Research Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Malaria Research and Control
- Blood disorders and treatments
- Long-Term Effects of COVID-19
- Hemoglobinopathies and Related Disorders
- Blood properties and coagulation
- Mosquito-borne diseases and control
- Hemostasis and retained surgical items
- Glycosylation and Glycoproteins Research
- Acute Ischemic Stroke Management
- Monoclonal and Polyclonal Antibodies Research
- Pharmaceutical Practices and Patient Outcomes
- Vitamin K Research Studies
- Central Venous Catheters and Hemodialysis
St. James's Hospital
2016-2025
Royal College of Surgeons in Ireland
2016-2025
University of Medicine and Health Sciences
2025
Irish Blood Transfusion Service
2023-2024
National Children’s Research Centre
2013-2023
Children's Health Ireland at Crumlin
2013-2023
St James's University Hospital
2023
Molecular Medicine Ireland
2022
Trinity College Dublin
2009-2020
Rowan University
2019-2020
<b><i>Background:</i></b> Warfarin increases mortality of intracerebral hemorrhage (ICH). The authors investigated whether this effect reflects increased baseline ICH volume at presentation or expansion. <b><i>Methods:</i></b> Subjects were drawn from an ongoing prospective cohort study outcome. warfarin on was studied in 183 consecutive cases supratentorial age ≥ 18 years admitted to the emergency department over a 5-year period. Baseline determined using computerized volumetric analysis....
Although the pathophysiology underlying severe COVID19 remains poorly understood, accumulating data suggest that a lung-centric coagulopathy may play an important role. Elevated D-dimer levels which correlated inversely with overall survival were recently reported in Chinese cohort studies. Critically however, ethnicity has major effects on thrombotic risk, 3-4-fold lower risk compared to Caucasians and significantly higher African-Americans. In this study, we investigated Caucasian...
von Willebrand disease (VWD) is the most common inherited bleeding disorder known in humans. Accurate and timely diagnosis presents numerous challenges.These evidence-based guidelines of American Society Hematology (ASH), International on Thrombosis Haemostasis (ISTH), National Hemophilia Foundation (NHF), World Federation (WFH) are intended to support patients, clinicians, other health care professionals their decisions about VWD diagnosis.ASH, ISTH, NHF, WFH established a multidisciplinary...
BackgroundPersistent fatigue, breathlessness, and reduced exercise tolerance have been reported following acute COVID‐19 infection. Although immuno‐thrombosis has implicated in pathogenesis, the biological mechanisms underpinning long COVID remain unknown. We hypothesized that pulmonary microvascular may be important this context.MethodsOne hundred fifty patients were reviewed at St James's Hospital Dublin between May September 2020 a median of 80.5 (range 44–155) days after initial...
Summary A recent report from the Leiden Thrombophilia Survey identified high factor VIII activity levels as an independent risk for venous thromboembolism in a population survey. As study measure was one-stage coagulation assay, and since markers acute phase reaction were not assessed, it remained uncertain whether increase due to constitutional increased rate of synthesis, circulating activated VIII, or response. We added assay (FVIII:C), antigen (FVIILAg), vWF (vWF:Ag), ABO blood group,...
Haemorrhage is a frequent manifestation of amyloidosis. We performed retrospective clinical analysis 337 patients with systemic immunoglobulin light-chain (AL)-amyloidosis, in whom whole-body serum amyloid P component (SAP) scintigraphy and clotting screen had been performed. Abnormal bleeding was noted 94 cases (28%), the coagulation abnormal 172 (51%). The most common abnormalities were prolongation thrombin time (TT; 108 cases, 32%) prothrombin (PT; 82 24%). In multivariate analysis,...
Summary Recent literature has suggested a role for elevated FVIII:C in venous thromboembolic disease (VTED). However since is known to rise response an acute phase reaction, it difficult determine whether the increased precedes thrombosis or represents secondary reactive phenomenon. In attempt address this question, we followed 35 patients with confirmed VTED, raised level (>1.5 iu/ml) and no other thrombotic tendency. Serial measurements of FVIII:C, vWF:Ag, C-reactive protein fibrinogen...
Summary Endothelial cell (EC) activation plays a key role in the pathogenesis of pulmonary microvascular occlusion, which is hallmark severe coronavirus disease 2019 (COVID‐19). Consistent with EC activation, increased plasma von Willebrand factor antigen (VWF:Ag) levels have been reported COVID‐19. Importantly however, studies other microangiopathies shown that VWF propeptide (VWFpp) more sensitive and specific measure acute activation. In present study, we further investigated nature...
BackgroundConsistent with fulminant endothelial cell activation, elevated plasma von Willebrand factor (VWF) antigen levels have been reported in patients COVID‐19. The multimeric size and function of VWF are normally regulated through A Disintegrin And Metalloprotease ThrombSpondin Motif type 1 motif, member 13 (ADAMTS‐13)‐‐mediated proteolysis.ObjectivesThis study investigated the hypothesis that ADAMTS‐13 regulation multimer distribution may be impaired severe acute respiratory...
BackgroundProlonged recovery is common after acute SARS-CoV-2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown. VWF/ADAMTS-13 imbalance, dysregulated angiogenesis, and immunothrombosis are hallmarks of COVID-19. We hypothesized that imbalance persists in convalescence together with endothelial cell (EC) activation angiogenic disturbance. Additionally, we postulate ongoing immune dysfunction may be linked to sustained EC coagulation...