A5088761876- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Intensive Care Unit Cognitive Disorders
- COVID-19 and Mental Health
- Hepatitis B Virus Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Antibiotic Use and Resistance
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Immune Cell Function and Interaction
- Stroke Rehabilitation and Recovery
- HIV, Drug Use, Sexual Risk
- Chronic Lymphocytic Leukemia Research
- Antimicrobial Resistance in Staphylococcus
- HIV/AIDS Research and Interventions
- Sepsis Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Viral Infections and Vectors
- Frailty in Older Adults
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- Inflammasome and immune disorders
- interferon and immune responses
St. James's Hospital
2016-2025
Trinity College Dublin
2017-2025
Royal Darwin Hospital
2007-2008
Fatigue is a common symptom in those presenting with symptomatic COVID-19 infection. However, it unknown if results persistent fatigue recovered from acute We examined the prevalence of individuals phase illness using Chalder Score (CFQ-11). further potential predictors following infection, evaluating indicators severity, markers peripheral immune activation and circulating pro-inflammatory cytokines. Of 128 participants (49.5 ± 15 years; 54% female), more than half reported (67/128; 52.3%)...
Rationale: Much is known about the acute infective process of severe respiratory syndrome coronavirus 2 (SARS-CoV-2), causative virus disease (COVID-19) pandemic. The marked inflammatory response and coagulopathic state in SARS-CoV-2 infection may promote pulmonary fibrosis. However, little incidence seriousness post–COVID-19 pathology. Objectives: To describe recovery self-reported health after at time outpatient attendance. Methods: Infection severity was graded into three groups: 1) not...
BackgroundPersistent fatigue, breathlessness, and reduced exercise tolerance have been reported following acute COVID‐19 infection. Although immuno‐thrombosis has implicated in pathogenesis, the biological mechanisms underpinning long COVID remain unknown. We hypothesized that pulmonary microvascular may be important this context.MethodsOne hundred fifty patients were reviewed at St James's Hospital Dublin between May September 2020 a median of 80.5 (range 44–155) days after initial...
Our aim was to describe episodic nature of disability among adults living with Long COVID.We conducted a community-engaged qualitative descriptive study involving online semistructured interviews and participant visual illustrations. We recruited participants via collaborator community organisations in Canada, Ireland, UK USA.We who self-identified as COVID diversity age, gender, race/ethnicity, sexual orientation duration since initial infection between December 2021 May 2022. used...
Background The long-term clinical and physiological consequences of COVID-19 infection remain unclear. While fatigue has emerged as a common symptom following infection, little is known about its links with autonomic dysfunction. SARS-CoV-2 to infect endothelial cells in acute resulting Here we set out test the hypothesis that this results persistent dysfunction associated post-COVID convalescent patients. Methods We recruited 20 fatigued non-fatigued patients (median age 44.5 years, 36/40...
Bacterial respiratory coinfection in the setting of SARS-CoV-2 infection remains poorly described. A description and antimicrobial usage is needed to guide ongoing stewardship.To assess rate empirical treatment COVID-19 cases, methods microbiological sampling, bacterial coinfections evaluate factors associated with therapy this cohort.Inpatients positive PCR were recruited. Antibiotic prescription, choice duration recorded. Taking samples (sputum culture, blood urinary antigens) culture...
BackgroundProlonged recovery is common after acute SARS-CoV-2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown. VWF/ADAMTS-13 imbalance, dysregulated angiogenesis, and immunothrombosis are hallmarks of COVID-19. We hypothesized that imbalance persists in convalescence together with endothelial cell (EC) activation angiogenic disturbance. Additionally, we postulate ongoing immune dysfunction may be linked to sustained EC coagulation...
Published studies suggest physical recovery from the COVID-19 is complex, with many individuals experiencing persistent symptoms. There a paucity of data investigating longer-term trajectory COVID-19.A prospective longitudinal design was utilised to investigate impact has on functioning at 10-weeks (T1), 6-months (T2) and 1-year (T3) post-hospital discharge. Objective measures included 6-Minute Walk Test Distance (6MWTD), frailty (Clinical Frailty Scale), quantification falls following...
Abstract Fatigue is a common symptom in those presenting with symptomatic COVID-19 infection. However, it unknown if results persistent fatigue recovered from acute We examined the prevalence of individuals phase illness using Chalder Score (CFQ-11). further potential predictors following infection, evaluating indicators severity, markers peripheral immune activation and circulating pro-inflammatory cytokines. Of 128 participants (49.5 ± 15 years; 54% female), more than half reported (52.3%;...
Abstract Obesity underpins the development of numerous chronic diseases, such as type II diabetes mellitus. It is well established that obesity negatively alters immune cell frequencies and functions. Mucosal-associated invariant T (MAIT) cells are a population innate cells, which we have previously reported dysregulated in obesity, with altered circulating adipose tissue reduction their IFN-γ production, critical effector function MAIT host defense. Hence, there increased urgency to...
Objectives The immunological and inflammatory changes following acute COVID-19 are hugely variable. Persistent clinical symptoms resolution of initial infection, termed long COVID , also variable, but association with has not been described. We investigate changing parameters in convalescent interrogate their potential relationships persistent symptoms. Methods performed paired immunophenotyping at SARS-CoV-2 infection convalescence (n=40, median 68 days) validated findings 71 further...
As the prevalence of Long COVID increases, there is a critical need for comprehensive assessment disability. Our aims are to: (1) characterise disability experiences among people living with in Canada, UK, USA and Ireland; (2) develop patient-reported outcome measure to assess presence, severity episodic nature COVID. In phase 1, we will conduct semistructured interviews adults explore (dimensions, uncertainty, trajectories, influencing contextual factors) establish an (ED) framework context...
Recently published observational data suggests an increased risk of herpes zoster infection post-vaccination with the BNT162b2 mRNA vaccine. We describe case VZV meningitis post vaccination in a young immunocompetent patient. A 39-year-old patient no medical history presented vesicular rash, headache, nausea and fever, days after receiving vaccination. CSF analysis revealed pleocytosis, DNA was confirmed by PCR testing. The received intravenous aciclovir resolution symptoms within 48 h. He...
SARS-CoV-2 infection causes a wide spectrum of disease severity. Identifying the immunological characteristics severe and risk factors for their development are important in management COVID-19. This study aimed to identify rank clinical features associated with progression COVID-19 order investigate an signature disease. One hundred eight patients positive PCR were recruited. Routine laboratory markers measured, as well myeloid lymphoid whole-blood immunophenotyping measurement...
Abstract Background Increasing numbers of adults are living with the health-related consequences Long COVID. The Episodic Disability Framework (EDF), derived from perspectives HIV, characterizes multidimensional and episodic nature challenges (disability) experienced by an individual. Our aim was to determine applicability conceptualize among Methods We conducted a community-engaged qualitative descriptive study involving online semi-structured interviews. recruited who self-identified as...
Background Increasing numbers of adults are living with the health-related consequences Long COVID. The Episodic Disability Framework (EDF), derived from perspectives HIV, characterizes multi-dimensional and episodic nature challenges (disability) experienced by an individual. Our aim was to determine applicability conceptualize among Methods We conducted a community-engaged qualitative descriptive study involving online semi-structured interviews. recruited who self-identified as COVID via...
Highlights•HIV-Vif protein targets Type 1 IFN JAK/STAT pathway proteins (STAT1 and STAT3) for proteasomal degradation.•HIV-Vif uses the host ECS E3 ligase complex to degrade STAT1 STAT3.•HIV-Vif blocks IFN-α-induced STAT phosphorylation anti-viral ISG induction.Even though I IFNs are strongly expressed upon viral infection, IFN-α fails cure HIV. Our study reveals that HIV-Vif mediates inhibition of IFN-α's responses through degradation its signalling cascade. These results outline mechanism...
Aims To assess clinical outcomes and adverse drug events in patients hospitalised with COVID‐19 treated off‐label hydroxychloroquine (HCQ) azithromycin (Az). Methods We performed a retrospective analysis of who had positive polymerase chain reaction test for SARS‐CoV‐2 received HCQ plus Az or no targeted therapy. The primary end point was improvement on day 7 defined as either hospital discharge an 2 points 6‐category ordinal scale. Secondary included mortality at 28, intensive care...
The emergence of persistent symptoms following SARS-CoV-2 infection, known as long COVID, is providing a new challenge to healthcare systems. cardinal features are fatigue and reduced exercise tolerance. Vitamin D have pleotropic effects far beyond bone health associated with immune modulation autoimmunity. We hypothesize that vitamin levels COVID-19. Herein, we investigate the relationship between tolerance, assessed by Chalder Fatigue Score, six-minute walk test modified Borg scale....
Background: Nearly 3 million people worldwide are coinfected with HIV and HCV. Affordable strategies for prevention needed. We developed a novel vaccination regimen involving replication-defective serologically distinct chimpanzee adenovirus (ChAd3, ChAdV63) vector priming followed by modified vaccinia Ankara (MVA) boosts, simultaneous delivery of HCV non-structural (NSmut) HIV-1 conserved (HIVconsv) region immunogens. Methods: conducted phase I trial in which 32 healthy volunteers were...
Administration of an MHC class II invariant chain–adjuvanted HCV vaccine in humans leads to enhanced immunogenicity via the proteasome pathway.
Background and aims People who inject drugs (PWID) are historically viewed as having “difficult to treat” hepatitis C disease, with perceived inferior treatment adherence outcomes, concerns regarding reinfection risk. We evaluated for differences in response Peginterferon-alfa-2a/Ribavirin (Peg-IFNα/RBV) a large urban cohort without history of remote or recent injection drug use. Methods Patient data was retrospectively reviewed 1000 consecutive patients—608 former (no injecting use 6 months...