A5048491760- Cancer survivorship and care
- Nutrition and Health in Aging
- Childhood Cancer Survivors' Quality of Life
- Esophageal Cancer Research and Treatment
- Frailty in Older Adults
- Esophageal and GI Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Risks and Factors
- Lymphatic System and Diseases
- Palliative Care and End-of-Life Issues
- Enhanced Recovery After Surgery
- Management of metastatic bone disease
- COVID-19 and healthcare impacts
- Lung Cancer Diagnosis and Treatment
- Physical Activity and Health
- Hip and Femur Fractures
- Meta-analysis and systematic reviews
- Cancer Diagnosis and Treatment
- Interprofessional Education and Collaboration
- Delphi Technique in Research
- Nutrition, Genetics, and Disease
- Cardiovascular and exercise physiology
- Hematopoietic Stem Cell Transplantation
- Telemedicine and Telehealth Implementation
- Hemodynamic Monitoring and Therapy
Trinity College Dublin
2016-2025
St. James's Hospital
2016-2025
Cancer Institute (WIA)
2023-2024
Trinity College
2023-2024
Hartford Financial Services (United States)
2023-2024
Total (France)
2019
University College Dublin
2019
Guy's and St Thomas' NHS Foundation Trust
2018
Versus Arthritis
2018
Cancer Trials Ireland
2011-2018
The aim of this article was to study the prevalence and significance sarcopenia in multimodal management locally advanced esophageal cancer (LAEC), assess its independent impact on operative oncologic outcomes.Sarcopenia may confer negative outcomes, but modern regimens for LAEC have not been systematically studied.Two hundred fifty-two consecutive patients were studied. Lean body mass (LBM), skeletal muscle index (SMI), fat (FM) determined pre-treatment, preoperatively, 1 year...
Preliminary evidence supports the beneficial role of physical activity on prostate cancer outcomes. This phase III randomised controlled trial (RCT) is designed to determine if supervised high-intensity aerobic and resistance exercise increases overall survival (OS) in patients with metastatic castrate-resistant (mCRPC).Participants (n=866) must have histologically documented progressive disease androgen deprivation therapy (defined as mCRPC). Patients can be treatment-naïve for mCRPC or...
Abstract Background Up to 40 per cent of patients undergoing oesophagectomy develop pneumonia. The aim this study was assess whether preoperative inspiratory muscle training (IMT) reduces the rate pneumonia after oesophagectomy. Methods Patients with oesophageal cancer were randomized a home-based IMT programme before surgery or usual care. included use flow-resistive loading device, and instructed train twice day at high intensity (more than 60 maximum strength) for 2 weeks longer until...
Published studies suggest physical recovery from the COVID-19 is complex, with many individuals experiencing persistent symptoms. There a paucity of data investigating longer-term trajectory COVID-19.A prospective longitudinal design was utilised to investigate impact has on functioning at 10-weeks (T1), 6-months (T2) and 1-year (T3) post-hospital discharge. Objective measures included 6-Minute Walk Test Distance (6MWTD), frailty (Clinical Frailty Scale), quantification falls following...
Objective: The Rehabilitation Strategies in Esophagogastric cancer (RESTORE) randomized controlled trial evaluated the efficacy of a 12-week multidisciplinary program to increase cardiorespiratory fitness and health-related quality life (HRQOL) esophagogastric survivors. Background: Patients following treatment for are at risk physical deconditioning, nutritional compromise, sarcopenia. Accordingly, compelling rationale exists target these impairments recovery. Methods: Disease-free patients...
Reduced physical functioning is common following resections for esophageal cancer; however, objective data on performance outcomes in this cohort are rare. The aim of study was to assess the and health related quality life (HRQOL) disease free survivors compare findings a case matched noncancer control group. Twenty-five males (mean (±SD) aged 63 (±6) years) who were over 6 months postesophagectomy disease-free compared with 25 controls (60 ± years). Physical assessed through hand grip...
To prospectively characterize changes in body weight, satiety, and postprandial gut hormone profiles following esophagectomy.With improved oncologic outcomes esophageal cancer, there is an increasing focus on functional status health-related quality of life survivorship. Early satiety weight loss are common after esophagectomy, but the pathophysiology these phenomena remains poorly understood.In this prospective study, consecutive patients undergoing esophagectomy with gastric conduit...
Esophageal resection is associated with a high incidence of postoperative pneumonia. Respiratory complications account for almost half the readmissions to critical care unit. Postoperative can result in prolonged hospital stay and consequently increase healthcare costs. In cardiac surgery preoperative inspiratory muscle training program has shown prevent pneumonia reduce length stay. While some surgical centers already used phase patients undergoing esophageal resection, added value this...
Oesophagectomy remains the only curative intervention for oesophageal cancer, with defined nutritional and health-related quality of life (HR-QOL) consequences. It follows therefore that there is a significant risk decline in physical wellbeing oesophagectomy however this has been inadequately quantified. This study prospectively examines change functioning habitual activity participation, from pre-surgery through 6-months post-oesophagectomy.Patients scheduled intent were recruited. Key...
Abstract Background Patients with cancer of the lung or oesophagus, undergoing curative treatment, usually require a thoracotomy and complex oncological resection. These surgeries carry risk major morbidity mortality, assessment, preoperative optimisation, enhanced recovery after surgery (ERAS) pathways are modern approaches to optimise outcomes. Pre-operative fitness is an established predictor postoperative outcome, accordingly, targeting pre-operative through exercise prehabilitation has...
Physical therapist-delivered rehabilitation aims to manage the side effects of cancer and its treatments. Although access is not yet a standard care in many countries, physical therapists practice types services with different populations. The purpose this study was explore experiences regard their role, factors influencing service delivery development, therapists' professional development needs.In qualitative semistructured interviews, settings Republic Ireland were interviewed via...