A5076383603- BRCA gene mutations in cancer
- Reading and Literacy Development
- Innovations in Educational Methods
- Reflective Practices in Education
- Visual and Cognitive Learning Processes
- Disability Education and Employment
- Antifungal resistance and susceptibility
- Collaborative Teaching and Inclusion
- Behavioral and Psychological Studies
- Education and Technology Integration
- Genetic factors in colorectal cancer
- Probiotics and Fermented Foods
- Teacher Education and Leadership Studies
- Colorectal and Anal Carcinomas
- Cancer Treatment and Pharmacology
- Nutrition, Genetics, and Disease
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Innovative Teaching and Learning Methods
- Cancer Genomics and Diagnostics
- Genetic Associations and Epidemiology
- Digital Accessibility for Disabilities
- HER2/EGFR in Cancer Research
- Cancer survivorship and care
- Radio, Podcasts, and Digital Media
University of Virginia
2016-2025
St. James's Hospital
2014-2024
University of South Carolina
2018-2024
Instituto Valenciano de la Edificación
2023
Gossamer Bio (United States)
2020-2022
Trinity College Dublin
2010-2021
Molecular Oncology (United States)
2011-2021
Virginia Department of Education
2016
Babraham Institute
2014
Birmingham Women's Hospital
2014
Reliable estimates of cancer risk are critical for guiding management BRCA1 and BRCA2 mutation carriers. The aims this study were to derive penetrance breast cancer, ovarian contralateral in a prospective series carriers assess how these risks modified by common susceptibility alleles. Prospective estimated using cohort 978 909 from the United Kingdom. Nine hundred eighty-eight women had no or diagnosis at baseline, 1509 unaffected 651 been diagnosed with unilateral cancer. Cumulative...
To analyze the baseline clinicopathologic characteristics of prostate tumors with germline BRCA1 and BRCA2 (BRCA1/2) mutations prognostic value those on cancer (PCa) outcomes.
Isolation of Clostridium difficile from fecal specimens has been facilitated by the development a selective and differential medium, cefoxitin-cycloserinefructose agar (CCFA). We substituted 0.1% sodium taurocholate for 2.5% egg yolk in CCFA compared growth 15 isolates C. on resulting medium with conventional CCFA. The taurocholate-containing (TCCFA) quantitatively recovered vegetative forms same numbers as medium. Recovery spores was mean 1.7 log(10) higher TCCFA than Thirty-six 60 patient...
BRCA1 and BRCA2 mutations have been associated with prostate cancer (PCa) risk but a wide range of estimates reported that are based on retrospective studies. To estimate relative absolute PCa risks BRCA1/2 to assess modification by age, family history, mutation location. This was prospective cohort study male (n = 376) carriers 447) identified in clinical genetics centres the UK Ireland (median follow-up 5.9 5.3 yr, respectively). Standardised incidence/mortality ratios (SIRs/SMRs)...
Many students entering middle school experience increased difficulty in acquiring academic content vocabulary, especially science. Content Acquisition Podcasts for Students (CAP-S) were developed over a decade ago to help remediate this issue and provide structured multimedia instruction on vocabulary improve the acquisition application of terms. This study sought expand CAP-S research base by examining impact three different formats understanding, retention, science terms rural inclusive...
Abstract BACKGROUND. Five years of treatment provides the optimum duration tamoxifen therapy for prevention breast cancer recurrence and mortality. Durations adjuvant less than 5 are associated with poorer outcomes patients. The purpose study was to assess rates nonpersistence (early discontinuation) in women aged 35 or older using prescription refill data from a national prescribing database. METHODS. A cohort 2816 commencing as initial hormonal identified between January 2001 2004....
<h3>Objective</h3> To examine the long-term effects of standard chemotherapy on myocardial function in asymptomatic breast cancer survivors using two-dimensional speckle tracking echocardiography. <h3>Methods</h3> Seventy women (chemotherapy group) aged 54±8 years who had received anthracycline treatment with (n=19) or without (n=51) adjuvant trastuzumab up to 6 previously, and 50 female controls were studied. Left ventricular systolic (ejection fraction (EF%), peak excursion, (Sm))...
Antibiotic-treated and untreated Syrian hamsters were inoculated intragastrically with Candida albicans to determine whether C. could opportunistically colonize the gastrointestinal tract disseminate visceral organs. Antibiotic treatment decreased total population levels of indigenous bacterial flora predisposed overgrowth subsequent systemic dissemination by in 86% animals. Both control not given antibiotics antibiotic-treated animals reconventionalized an microflora showed significantly...
Abstract The known breast cancer susceptibility polymorphisms in FGFR2, TNRC9/TOX3, MAP3K1, LSP1, and 2q35 confer increased risks of for BRCA1 or BRCA2 mutation carriers. We evaluated the associations 3 additional single nucleotide (SNPs), rs4973768 SLC4A7/NEK10, rs6504950 STXBP4/COX11, rs10941679 at 5p12, reanalyzed previous using carriers a sample 12,525 7,409 Additionally, we investigated potential interactions between SNPs assessed implications risk prediction. minor alleles were...
Abstract Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood spleen. Using expression quantitative trait loci (eQTL) reported these identify 26 previously unreported, likely target genes of overall risk variants, 17 for estrogen receptor (ER)-negative cancer, several with a known function. We...
objectives: The purpose of this study was to determine the influence fatigue, pain, and depression on health status in breast cancer patients who had completed adjuvant chemotherapy were scheduled for autologous bone marrow/peripheral blood stem cell transplant (AT). materials methods: A predictive, correlational design used. convenience sample 127 women with stages II, III, IV recruited. setting an urban National Cancer Institute‐designated comprehensive center located Eastern United...
Patients with breast cancer who undergo autologous bone marrow/peripheral blood stem cell transplantation (ABMT) cope not only a life-threatening medical treatment, but also multiple, interrelated symptoms including pain, fatigue, psychological distress, and nausea. The purpose of this study was to determine, in randomized controlled clinical trial, whether comprehensive coping strategy program (CCSP) effective significantly reducing nausea patients underwent ABMT. CCSP composed preparatory...
Mice were treated orally with various antibiotics to determine which members of the indigenous intestinal microflora normally suppress Candida albicans colonization and dissemination from gastrointestinal (GI) tract. The mice given penicillin, clindamycin, vancomycin, erythromycin, or gentamicin for 3 days, then challenged C. albicans. Penicillin, but not decreased total anaerobic bacterial populations in animals ceca, increased enteric bacilli population levels. All three former allowed...
Universal Design for Learning (UDL) is a framework that commonly used guiding the construction and delivery of instruction intended to support all students. In this study, we related model guide creation multimedia-based instructional tool called content acquisition podcasts (CAPs). CAPs delivered vocabulary during two concurrent social studies units 32 SWD 109 students without disabilities. We created using combination evidence-based practices instruction, UDL, Mayer’s design principles....
Technology, whether assistive (AT) or instructional (IT), has played an uneven role in the field of learning disabilities since its inception more than a half century ago. In addition, technology is constant state flux; hence, researchers have been challenged to conduct appropriate experimental testing interventions before they are outdated made irrelevant by advances hardware and software. As schools seek improve outcomes for all students using tiered models such as response intervention...
As hepatitis B virus (HBV) infection in renal transplant recipients is associated with a high incidence of progressive liver disease it may be inadvisable to hemodialysis patients antigenemia. To determine the natural history HBV patients, all 49 on treatment for at least 1 year, 3 centers, who developed circulating surface antigen (HBsAG), were studied. A subgroup these (n = 31) aged less than or equal 50 years, followed 55 +/- 6 months after detection HBsAg was compared 22 previously...
Two single nucleotide polymorphisms (SNPs) at 6q25.1, near the ESR1 gene, have been implicated in susceptibility to breast cancer for Asian (rs2046210) and European women (rs9397435). A genome-wide association study Europeans identified two further variants: rs11249433 1p11.2 rs999737 RAD51L1 14q24.1. Although previously variants shown be associated with risk BRCA1 BRCA2 mutation carriers, involvement of these SNPs carriers is currently unknown. To address this, we genotyped from 42 studies...
Early detection, clinical management and disease recurrence monitoring are critical areas in cancer treatment which specific biomarker panels likely to be very important each of these key areas. We have previously demonstrated that levels alpha-2-heremans-schmid-glycoprotein (AHSG), complement component C3 (C3), clusterin (CLI), haptoglobin (HP) serum amyloid A (SAA) significantly altered from patients with squamous cell carcinoma the lung. Here, we report abundance for proteins samples...
The purpose of this experimental study is to investigate the effects using content acquisition podcasts (CAPs), an example instructional technology, provide vocabulary instruction adolescents with and without learning disabilities (LD). A total 279 urban high school students, including 30 LD in area related reading, were randomly assigned one four conditions occurring at individual computer terminals over a 3-week period. Each contained different configurations multimedia-based...