A5080825465- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- HIV, Drug Use, Sexual Risk
- Immune Cell Function and Interaction
- Cystic Fibrosis Research Advances
- Sepsis Diagnosis and Treatment
- Respiratory viral infections research
- Viral-associated cancers and disorders
- Bacterial Infections and Vaccines
- Hepatitis C virus research
- Inhalation and Respiratory Drug Delivery
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Complement system in diseases
- Tuberculosis Research and Epidemiology
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- vaccines and immunoinformatics approaches
- Systemic Lupus Erythematosus Research
- Bacterial biofilms and quorum sensing
- Bacillus and Francisella bacterial research
Copenhagen University Hospital
2015-2025
University of Copenhagen
2011-2025
Amager Hospital
2003-2025
Hvidovre Hospital
2014-2024
AIDS Fondet
2024
Janssen (Belgium)
2022
Riga East University Hospital
2021
Charles University
2015
Rigshospitalet
1992-2007
Odense University Hospital
2006-2007
Background: The expected survival of HIV-infected patients is major public health interest. Objective: To estimate time and age-specific mortality rates an population compared with that the general population. Design: Population-based cohort study. Setting: All persons receiving care in Denmark from 1995 to 2005. Patients: Each member nationwide Danish HIV Cohort Study was matched as many 99 according sex, date birth, municipality residence. Measurements: authors computed Kaplan–Meier life...
Background. We assessed mortality attributable to smoking among patients with human immunodeficiency virus (HIV). Methods. estimated rates (MRs), rate ratios (MRRs), life expectancies, life-years lost, and population-attributable risk of death associated HIV current nonsmoking individuals from a population-based, nationwide cohort matched HIV-negative individuals. Results. A total 2921 10 642 controls were followed for 14 281 45 122 person-years, respectively. All-cause non-AIDS-related was...
There are concerns about highly active antiretroviral therapy (HAART) causing a progressive increase in the risk of ischemic heart disease. We examined this issue nationwide cohort study patients with human immunodeficiency virus (HIV) infection and population-based control group.We determined rate first hospitalization for disease all Danish HIV (3953 patients) from 1 January 1995 through 31 December 2004 compared that 373,856 subjects group. Data on comorbidity were obtained National...
A daily dose with 6 mg of dexamethasone is recommended for up to 10 days in patients severe and critical COVID-19, but a higher may benefit those more disease.To assess the effects 12 mg/d vs COVID-19 hypoxemia.A multicenter, randomized clinical trial was conducted between August 2020 May 2021 at 26 hospitals Europe India included 1000 adults confirmed requiring least L/min oxygen or mechanical ventilation. End 90-day follow-up on 19, 2021.Patients were 1:1 intravenous (n = 503) 497)...
Abstract Introduction Accurate and timely diagnosis of community-acquired bacterial infections in patients with systemic inflammation remains challenging both for clinician laboratory. Combinations markers, as opposed to single ones, may improve thereby survival. We therefore compared the diagnostic characteristics novel routinely used biomarkers sepsis alone combination. Methods This prospective cohort study included inflammatory response syndrome who were suspected having infections. It...
Previous studies have shown associations between low mannose-binding lectin (MBL) level or variant MBL2 genotype and sepsis susceptibility. However, MBL deficiency has not been rigorously defined, with outcomes subjected to multivariable analysis.We reanalyzed results in a large cohort use of individual data from 4 involving total 1642 healthy control subjects systematically defined reliable cutoff. Subsequently, were reassessed extend previous associations, adjustment for known outcome...
Background. Human immunodeficiency virus (HIV) infection predisposes to progressive multifocal leukoencephalopathy (PML). Here, we describe the incidence, presentation, and prognosis of PML in HIV-1-infected patients during period before highly active antiretroviral therapy (HAART) (1995–1996) early HAART (1997–1999) late (2000–2006) periods. Methods. Patients from a nationwide population-based cohort adult individuals were included. We calculated incidence rates median survival times after...
Objective To determine whether variant alleles in the coding portion of mannose-binding lectin (MBL) gene are associated with increased susceptibility to systemic lupus erythematosus (SLE) and concomitant infections. Methods MBL serum concentrations were determined by polymerase chain reaction enzyme-linked immunosorbent assay, respectively, 91 Danish patients SLE 250 controls. Results Homozygosity for MBL was observed 7.7% compared 2.8% controls (P = 0.06), while no...
Objective: To assess the risk of cerebrovascular events (CVEs) in HIV-infected individuals and evaluate impact proven factors, injection drug abuse (IDU), immunodeficiency, HAART family-related factors. Design: Nationwide, population-based cohort study. Methods: The study population included all Danish individuals, a comparison parents both cohorts – with no prior cerebral comorbidity. We computed incidence rate ratios (IRRs) overall CVEs without stratifying analyses on IDU. Impact HAART,...
To compare fracture risk in persons with and without HIV infection to examine the influence of highly active antiretroviral therapy (HAART) initiation on fracture.Population-based nationwide cohort study using Danish registries.Outcome measures were time first at any site, low-energy high-energy HIV-infected patients (n = 5306) compared a general population control 26 530) matched by sex age during period 1995-2009. Cox regression analyses used estimate incidence rate ratios...
Background We determined the impact of three factors on mortality in HIV-infected patients who had been highly active antiretroviral therapy (HAART) for at least one year: (1) insufficient response to and presence AIDS-defining diseases, (2) comorbidity, (3) drug alcohol abuse compared that general population. Methodology/Principal Findings In a Danish nationwide, population-based cohort study, we used population based registries identify all started HAART period 1 January 1998–1 July 2009,...
The aim of the study was to examine whether exposure abacavir increases risk for myocardial infarction (MI).This a prospective nationwide cohort which included all Danish HIV-infected patients on highly active antiretroviral therapy (HAART) from 1995 2005 (N = 2952). Data hospitalization MI and comorbidity were obtained medical databases. Hospitalization rates after HAART initiation calculated who used those did not. We Cox's regression compute incidence rate ratios (IRR) as measure relative...
Objective In a nationwide, population-based cohort study we assessed the risk of diabetes mellitus (DM) in HIV-infected individuals compared with general population, and evaluated impact factors for DM individuals. Methods We identified 4,984 Danish-born from Danish HIV Cohort Study born age- gender-matched comparison 19,936 (study period: 1996–2009). Data on was obtained National Hospital Registry Prescription Registry. Incidence rate ratios (IRR) including exposure to Highly Active...
Abstract Background. Human immunodeficiency virus-infected individuals have increased risk of myocardial infarction (MI); however, the contribution from smoking and potentiating effects HIV are controversial. Methods. From Danish Cohort Study Copenhagen General Population Study, we identified 3251 HIV-infected 13 004 population controls matched on age gender. Data MI were obtained National Hospital Registry Causes Death. We calculated adjusted incidence rate ratios (aIRR) for...
CD163, a monocyte- and macrophage-specific scavenger receptor, is shed as soluble CD163 (sCD163) during the proinflammatory response. Here, we assessed association between plasma sCD163 levels progression to AIDS all-cause mortality among individuals infected with human immunodeficiency virus type 1 (HIV).Plasma were measured in 933 HIV-infected individuals. Hazard ratios (HRs) 95% confidence intervals (CIs) associated computed by Cox proportional hazards regression.At baseline, 86%...
Background: Although the prevalence of HIV-infection among individuals ≥50 years age has increased, impact on risk death in this population remains to be established. Our aim was estimate long-term mortality HIV-infected who were 50 or older, when compared with an individually-matched cohort from background population. Methods: Population-based cohort-study including years, alive 1 year after HIV-diagnosis (n = 2440) and a comparison by gender extracted 14,588). Cumulative survival evaluated...
Objectives. To examine trajectories of CD8+ T-cell counts before and after combination antiretroviral therapy (cART) in human immunodeficiency virus (HIV)-infected individuals associations with mortality. Methods. were measured 3882 HIV-infected who received care Copenhagen during 1995–2012. Reference values obtained from 1230 persons the background population. Mortality rate ratios estimated by Poisson regression. Results. elevated untreated HIV infection remained through 10 years cART. A...
The relative impact of immune deficiency and lifestyle-related factors on risk cancer in the HIV-infected population is controversial. We aimed to estimate population-attributable fractions (PAFs) associated with smoking, being deficiency.In a Danish, nationwide, population-based cohort study (1995-2011), incidences were compared between an matched analyses stratified category, smoking status for HIV patients: low CD4 cell count.We included 3503 patients [baseline CD4+ 450 cells/μl...
To determine whether variant alleles in the coding portion of mannose-binding lectin (MBL) gene are associated with increased susceptibility to systemic lupus erythematosus (SLE) and concomitant infections.MBL serum concentrations were determined by polymerase chain reaction enzyme-linked immunosorbent assay, respectively, 91 Danish patients SLE 250 controls.Homozygosity for MBL was observed 7.7% compared 2.8% controls (P = 0.06), while no difference seen heterozygosity (33.0% versus 34.4%)....
ABSTRACT The purpose of this study was to investigate whether an age-associated impaired acute-phase response exists. Nine healthy elderly volunteers (median, 66 years; range, 61 69 years) and eight young controls 24 20 27 were given intravenous bolus endotoxin (2 ng/kg). rectal temperature monitored continuously, blood samples for cytokine measurements obtained before administration as well 0.5, 1, 1.5, 2, 3, 4, 8, 12, h after the injection. subjects showed a more prolonged fever compared...
Insulin therapy to maintain euglycemia increases survival in critically ill patients. To explore possible mechanisms of action, we investigated the effect endotoxin on circulating cytokines, free fatty acids (FFA), and leukocytes during manipulated plasma glucose insulin concentrations. Ten volunteers underwent three trials each, receiving an intravenous bolus (0.2 ng/kg) normoglycemia (trial A, control), a hyperglycemic clamp at 15 mM B), hyperinsulinemic euglycemic C). Endotoxin induced...
Soluble CD163 (sCD163) is a new macrophage-specific serum marker. This study investigated sCD163 and other markers of macrophage activation (neopterin, ferritin, transcobalamin, soluble urokinase plasminogen activator receptor [suPAR]) as prognostic factors in patients with pneumococcal bacteremia.Observational cohort study.Five university hospitals Denmark.A total 133 Streptococcus pneumoniae bacteremia (positive blood culture) age- gender-matched controls.Samples were collected for...