Background: The expected survival of HIV-infected patients is major public health interest. Objective: To estimate time and age-specific mortality rates an population compared with that the general population. Design: Population-based cohort study. Setting: All persons receiving care in Denmark from 1995 to 2005. Patients: Each member nationwide Danish HIV Cohort Study was matched as many 99 according sex, date birth, municipality residence. Measurements: authors computed Kaplan–Meier life...

Background. We assessed mortality attributable to smoking among patients with human immunodeficiency virus (HIV). Methods. estimated rates (MRs), rate ratios (MRRs), life expectancies, life-years lost, and population-attributable risk of death associated HIV current nonsmoking individuals from a population-based, nationwide cohort matched HIV-negative individuals. Results. A total 2921 10 642 controls were followed for 14 281 45 122 person-years, respectively. All-cause non-AIDS-related was...

To compare fracture risk in persons with and without HIV infection to examine the influence of highly active antiretroviral therapy (HAART) initiation on fracture.Population-based nationwide cohort study using Danish registries.Outcome measures were time first at any site, low-energy high-energy HIV-infected patients (n = 5306) compared a general population control 26 530) matched by sex age during period 1995-2009. Cox regression analyses used estimate incidence rate ratios...

Background We determined the impact of three factors on mortality in HIV-infected patients who had been highly active antiretroviral therapy (HAART) for at least one year: (1) insufficient response to and presence AIDS-defining diseases, (2) comorbidity, (3) drug alcohol abuse compared that general population. Methodology/Principal Findings In a Danish nationwide, population-based cohort study, we used population based registries identify all started HAART period 1 January 1998–1 July 2009,...

The aim of the study was to examine whether exposure abacavir increases risk for myocardial infarction (MI).This a prospective nationwide cohort which included all Danish HIV-infected patients on highly active antiretroviral therapy (HAART) from 1995 2005 (N = 2952). Data hospitalization MI and comorbidity were obtained medical databases. Hospitalization rates after HAART initiation calculated who used those did not. We Cox's regression compute incidence rate ratios (IRR) as measure relative...

Background: Although the prevalence of HIV-infection among individuals ≥50 years age has increased, impact on risk death in this population remains to be established. Our aim was estimate long-term mortality HIV-infected who were 50 or older, when compared with an individually-matched cohort from background population. Methods: Population-based cohort-study including years, alive 1 year after HIV-diagnosis (n = 2440) and a comparison by gender extracted 14,588). Cumulative survival evaluated...

Human immunodeficiency virus (HIV)-infected individuals with high CD4(+) cell counts may have increased susceptibility to other infections. We compared incidence rates of pneumonia among and without HIV infection explored risk factors for in the HIV-infected population.This was an observational cohort study conducted during 1995-2007. Each member a Danish population-based nationwide matched up 99 control from general population. Data on age, mortality, emigration, hospital discharge...

The mortality in patients with persistent low CD4 count despite several years of HAART sustained viral suppression is poorly documented. We aimed to identify predictors for inadequate cell recovery and estimate but otherwise successful HAART.In a nationwide cohort HIV we identified all individuals who started before 1 January 2005 ≤ 200 cells/μL experienced three suppression. Patients were categorized according after the suppressed period (≤ cells/μL; immunological non-responders (INRs),...

Background. The clinical implications of a considerable CD4 decline despite antiretroviral treatment and viral suppression are unknown. We aimed to test the hypothesis that major could be marker cardiovascular disease or undiagnosed cancer.

Background. Invasive pneumococcal disease (IPD) is an important cause of morbidity among individuals infected with human immunodeficiency virus (HIV). We described incidence and risk factors for IPD in HIV-infected uninfected individuals.

BackgroundPatients with atherosclerotic plaques containing high-risk features have an increased likelihood of events and a worse prognosis. Whether levels Troponin I (TnI) C-reactive protein (CRP) are associated the presence coronary (HRP) is not well described. We assessed association between 1) TnI 2) CRP quantified plaque burden, luminal diameter stenosis, HRP in patients low/intermediate pre-test probability obstructive artery disease (CAD) referred for computed tomography angiography...

Objective: To investigate physical, psychosocial and sexual health outcomes in ≥50 years-old people with without HIV. Design: Cross-sectional study Denmark comparing by HIV status. Methods: Data were drawn from the SHARE study, a nationwide survey conducted between 2021 2022, examining psychosocial, reproductive (PWH), compared to data (PWOH) nationally representative Project SEXUS cohort study. Health assessed using validated patient-reported outcome measures, sex-stratified logistic...

AbstractOur objective was to determine the impact on mortality of coverage and spectrum initial empirical antimicrobial treatment among bacteraemic patients in county Northern Jutland, Denmark. Patients aged > 15 y from bacteraemia register who had their first episode between 1996 1998 were retrospectively included. Outcome defined as survival day that positive blood culture taken. Follow-up 180 d. Survival probability estimated using a Cox proportional hazard model. Conservative penicillin...

The objectives of this study were to estimate the data quality haematological malignancy diagnoses in a hospital discharge registry, and quantify impact any misclassification on survival estimates. We included all patients > or = 15 years living North Jutland County, Denmark with first-time diagnosis registered Hospital Discharge Registry Danish Cancer Registry, reference standard, from 1994 1999. estimated completeness positive predictive value (PPV) malignancies specific subcategories, as...

We aimed to assess retention of HIV-infected individuals in the Danish healthcare system over a 15-year period.Loss follow-up (LTFU) was defined as 365 days without contact HIV care system. Data were obtained from nationwide Cohort study, The National Hospital Registry and Civil Registration System. Incidence rates, risk factors for LTFU return mortality rate ratios (MRRs) estimated using Poisson regression analyses.We included 4745 patients who followed 36,692 person-years. Patients...

HIV patients have increased risk of impaired renal function. We aimed to estimate the incidence any replacement therapy (aRRT) and start chronic (cRRT) among compared with population controls.In a nationwide, population-based cohort study we analysed rates (IR), rate ratios (IRR) factors for aRRT cRRT an age- gender-matched control using Poisson regression.We identified 5300 53 000 controls. The IRs per 10 person-years were 15.9 (95% CI: 12.5-20.1) 4.4 2.8-6.9), respectively. IRR was 4.7...

We aimed to estimate the incidence and predictors of late presentation among human immunodeficiency virus (HIV)-infected individuals in Denmark.Incidence rates (IR) with advanced HIV (CD4 < 200 cells/μl and/or acquired immune deficiency syndrome (AIDS)) 350 AIDS) were calculated per 100,000 population aged 16-60 y. Mortality rate ratios (MRR) estimated using Poisson regression analysis.Three thousand twenty-seven diagnosed 1995-2009; 34.7% presented 51.2% presenters. The IR was stable...

Abstract Background The success of antiretroviral therapy has normalized pregnancy among women living with HIV (WWH) a very low risk perinatal transmission HIV. Despite these advances, WWH still face complex medical and psychosocial issues during postpartum. aim this study was to assess differences in health outcomes between pregnant WWH, non-pregnant without HIV, further identify factors associated probable depression the third trimester Methods In longitudinal survey study, participants...

Objective: Individuals with HIV experience an increased risk of lymphoma, making this important cause death among people HIV. Nevertheless, little is known regarding the underlying genetic aberrations, which we therefore set out to characterize. Design: We conducted next-generation panel sequencing explore mutational status diagnostic lymphoma biopsies from 18 patients diagnosed secondary infection. Methods: Ion Torrent was performed AmpliSeq on HIV-associated B-cell lymphomas ( n = 18),...

Women living with HIV (WLWH) are at increased risk of persistent human papillomavirus (HPV) infection, cervical dysplasia and cancer compared women from the general population (WGP). We assessed prevalence distribution high-risk (hr) HPV infection cytological abnormalities in WLWH WGP Denmark. Predictors were estimated WLWH. consecutively enrolled Study on HIV, Abnormalities infections Denmark (SHADE) 2011 examined for abnormalities. matched age prior findings an earlier study. demographics...