A5029326001- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging Techniques and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Cancer survivorship and care
- Medical Imaging and Pathology Studies
- Advanced Radiotherapy Techniques
- Cancer Genomics and Diagnostics
- Music Therapy and Health
- Radiation Therapy and Dosimetry
- Sarcoidosis and Beryllium Toxicity Research
- Liver Disease Diagnosis and Treatment
- Statistical Methods and Bayesian Inference
- Genetic factors in colorectal cancer
- Sports injuries and prevention
- Sepsis Diagnosis and Treatment
- Tracheal and airway disorders
- Statistical Methods and Inference
- Respiratory viral infections research
- Neuroscience and Music Perception
- Head and Neck Cancer Studies
- Inhalation and Respiratory Drug Delivery
University of Copenhagen
2009-2025
Copenhagen University Hospital
2006-2025
University of Arizona
2025
Frederiksberg Hospital
2015-2025
Bispebjerg Hospital
2014-2024
Rigshospitalet
2006-2023
Amsterdam UMC Location University of Amsterdam
2016
Hvidovre Hospital
2004-2015
Society of Thoracic Surgeons
2015
Capital Region of Denmark
2015
Fast and accurate staging is essential for choosing treatment non–small-cell lung cancer (NSCLC). The purpose of this randomized study was to evaluate the clinical effect combined positron-emission tomography computed (PET–CT) on preoperative NSCLC.
Summary. Logistic regression with random effects is used to study the relationship between explanatory variables and a binary outcome in cases nonindependent outcomes. In this paper, we examine detail interpretation of both fixed parameters. As heterogeneity measures, parameters included model are not easily interpreted. We discuss different alternative measures suggest using median odds ratio measure that function original The allows simple interpretation, terms well‐known ratios, greatly...
<h3>Background</h3> The effects of low-dose CT screening on disease stage shift, mortality and overdiagnosis are unclear. Lung cancer findings rates reported at the end in Danish Cancer Screening Trial. <h3>Methods</h3> 4104 men women, healthy heavy smokers/former smokers were randomised to five annual screenings or no screening. Two experienced chest radiologists read all scans registered location, size morphology nodules. Nodules between 5 15 mm without benign characteristics rescanned...
Abstract Non-invasive approaches for cell-free DNA (cfDNA) assessment provide an opportunity cancer detection and intervention. Here, we use a machine learning model detecting tumor-derived cfDNA through genome-wide analyses of fragmentation in prospective study 365 individuals at risk lung cancer. We validate the using independent cohort 385 non-cancer 46 patients. Combining features, clinical factors, CEA levels, followed by CT imaging, detected 94% patients with across stages subtypes,...
As of April 2015, participants in the Danish Lung Cancer Screening Trial had been followed for at least 5 years since their last screening.Mortality, causes death, and lung cancer findings are reported to explore effect computed tomography (CT) screening.A total 4,104 aged 50-70 time inclusion with a minimum 20 pack-years smoking were randomized have five annual low-dose CT scans (study group) or no screening (control group).Follow-up information regarding date cause diagnosis, stage,...
Abstract Introduction Accurate and timely diagnosis of community-acquired bacterial infections in patients with systemic inflammation remains challenging both for clinician laboratory. Combinations markers, as opposed to single ones, may improve thereby survival. We therefore compared the diagnostic characteristics novel routinely used biomarkers sepsis alone combination. Methods This prospective cohort study included inflammatory response syndrome who were suspected having infections. It...
Objective. There is increasing focus on non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to conduct a long-term clinical follow-up patients with biopsy-confirmed without inflammation or significant fibrosis (pure liver), analyse for potential risk factors at time index biopsy important survival and development cirrhosis describe causes death. Material methods. Patients were linked through their personal identification number Danish National Registry Register Causes...
Knowledge of the effect differences in iodine intake levels on public health areas with no endemic goiter is limited. Groups at risk when relatively low are pregnant and lactating women their newborns. A prospective randomized study was performed to evaluate supplementation an area where median daily excretion urine around 50 micrograms. Fifty-four normal were be controls or receive 200 micrograms iodine/day from weeks 17-18 pregnancy until 12 months after delivery. In control group, serum...
Groin injuries cause major problems in sports and particularly football. Exercise is effective treating adductor-related groin pain, but no trials have been published regarding the specific prevention of pain or specifically targeting overuse sport using exercise programs. We performed a cluster-randomized trial including 55 football clubs representing 1211 players. The were randomized to an program aimed at preventing (n=27) control group training as usual (n=28). intervention consisted six...
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is very operator dependent and has a long learning curve. Simulation-based training might shorten the curve, an assessment tool with solid validity evidence could ensure basic competency before unsupervised performance. A total of 16 respiratory physicians, without EBUS experience, were randomised to either virtual-reality simulator or traditional apprenticeship on patients, then each physician performed EBUS-TBNA...
Background It is unknown whether an exercise program can prevent overuse injuries in the lower extremity. An often encountered and important risk factor for development of extremity abrupt increase activity level. Hypothesis A preventive training based on a literature review intrinsic factors, performed concurrent with physical activity, reduce incidence knee medial tibial stress syndrome, as well running distance. Study Design Randomized controlled trial; Level evidence, 1. Methods total...
Thirty‐one adult patients with asthma caused by house‐dust mites (HDM) were included in this placebo‐controlled, double‐blind study to evaluate the efficacy and safety of specific immunotherapy (SIT) biologically standardized extracts HDM. The diagnosis was confirmed skin prick tests, IgE, bronchial provocation tests HDM allergens. randomized receive active treatment either Dermatophagoides pteronyssinus (Dpt) or D. farinae (Dfa) (Alutard® SQ, ALK, Denmark) placebo injections. Twenty‐three...
Correct mediastinal staging is a cornerstone in the treatment of patients with non-small cell lung cancer. A large range methods available for this purpose, making process adequate complex. The objective study was to describe faults and benefits positron emission tomography (PET)-CT multimodality staging.A randomised clinical trial conducted including verified diagnosis cancer, who were considered operable. Patients assigned PET-CT (PET-CT group) followed by invasive (mediastinoscopy and/or...
EGFR mutation frequencies in unselected Caucasian populations are unknown. This study assesses the prevalence of mutations an population‐based cohort, and correlation between gender, age, ethnicity, smoking habits, pathological data. NSCLC patients diagnosed a well‐defined Danish population were included. The type diagnostic material, data on registered. analyses investigated by Therascreen RGQ ‐ PCR Kit or Sanger sequencing. A total 658 men 598 women 6.2% never smokers, 38.9% ex‐smokers,...
Diagnosing relapse after radiotherapy for lung cancer is challenging. The specificity of both CT and <sup>18</sup>F-FDG PET/CT low because radiation-induced changes. 3′-deoxy-3′-<sup>18</sup>F-fluorothymidine (<sup>18</sup>F-FLT) PET has previously demonstrated higher malignancy than PET. We investigated the value <sup>18</sup>F-FLT diagnosing in irradiated cancer. <b>Methods:</b> Patients suspected definitive (conventional fractionated [cRT] or stereotactic body [SBRT]) were included....
The aim of this study was to evaluate which parameters preoperative spirometry and cardiopulmonary exercise test are the best predictors postoperative morbidity mortality in patients with bronchogenic carcinoma. Ninety seven were prospectively consecutively examined. All had maximal dynamic spirometry. Postoperative complications causes death registered. Logistic regression used models explaining relationship between variables deaths constructed. We found significant differences workload...
<i>Background:</i> There have been several attempts to systematically assess performance in bronchoscopy. Earlier validation studies used bronchoscopy simulators, not real-life patients. <i>Objectives:</i> The aim of this study was explore the reliability and validity an assessment tool aimed for use a clinical setting. <i>Methods:</i> Five junior residents, 5 senior residents 9 consultants performed 3 bronchoscopies each. All 57 were video-recorded...
Introduction. Surgical resection in patients with non–small cell lung cancer (NSCLC) may be associated significant morbidity, functional limitations, and decreased quality of life. Objectives. The safety feasibility a preoperative early postoperative rehabilitation program operated for NSCLC was determined nonhospital setting, focus on high-intensity interval exercise. Methods. Forty biopsy-proven stages I to IIIa referred surgical at the Department Cardiothoracic Surgery RT, Rigshospitalet,...