A5069322426- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Bone health and treatments
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Monoclonal and Polyclonal Antibodies Research
- Venous Thromboembolism Diagnosis and Management
- Cancer therapeutics and mechanisms
- Shoulder Injury and Treatment
- Childhood Cancer Survivors' Quality of Life
- Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Cytokine Signaling Pathways and Interactions
- Research on Leishmaniasis Studies
- Bone and Joint Diseases
- Tendon Structure and Treatment
- Histone Deacetylase Inhibitors Research
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Blood Coagulation and Thrombosis Mechanisms
Aalborg University Hospital
2016-2025
Aalborg University
1997-2024
Nordic Myeloma Study Group
2022
Aarhus University Hospital
2006-2021
Aarhus University
2009-2021
Faculty (United Kingdom)
2013
Svendborg Sygehus
1997-2012
Mech-Sense
2009
Haukeland University Hospital
2007
Tallaght University Hospital
2007
Background: Some autoimmune and chronic inflammatory disorders are associated with increased risks of non-Hodgkin lymphoma (NHL). Because different NHL subtypes develop at stages lymphocyte differentiation, associations specific could lead to a better understanding lymphomagenic mechanisms. Methods: In population-based case–control study in Denmark Sweden, 3055 patients 3187 matched control subjects were asked about their history disorders, markers severity, treatment. Logistic regression...
Knowledge of the effect differences in iodine intake levels on public health areas with no endemic goiter is limited. Groups at risk when relatively low are pregnant and lactating women their newborns. A prospective randomized study was performed to evaluate supplementation an area where median daily excretion urine around 50 micrograms. Fifty-four normal were be controls or receive 200 micrograms iodine/day from weeks 17-18 pregnancy until 12 months after delivery. In control group, serum...
The objective of this guideline is to provide healthcare professionals with clear guidance for the effective clinical investigation patients newly detected M-proteins and practical management monoclonal gammopathy undetermined significance (MGUS). may not be appropriate all individual patient circumstances dictate an alternative approach. members joint group UK Myeloma Forum (UKMF) Nordic Study Group (NMSG) were selected representative UK-based based medical experts representatives. MEDLINE...
Biomedical science and its allied disciplines are entering a new era in which computational methods technologies poised to play prevalent role supporting collaborative investigation of the human body. Within Europe, this has focus virtual physiological (VPH), is an evolving entity that emerged from EuroPhysiome initiative strategy for (STEP) consortium. The VPH intended be solution common infrastructure needs physiome projects across globe, providing unifying architecture facilitates...
Several risk scores for disease progression in patients with smoldering multiple myeloma (SMM) have been proposed; however, all developed using single-center registries. To examine factors time to (TTP) (MM) SMM, we analyzed a nationwide population-based cohort of 321 newly diagnosed SMM registered within the Danish Multiple Myeloma Registry between 2005 and 2014. Significant univariable TTP were selected multivariable Cox regression analyses. We found that both an M-protein ≥30 g/L...
Importance In recent years, there has been a focus on reducing the socioeconomic gap in survival for hematological malignant neoplasms. Understanding developments is important to develop further intervention improve care. Objective To investigate temporal trend associations of status (SES) with among 3 aggressive neoplasms: multiple myeloma (MM), acute myeloid leukemia (AML), and diffuse large B-cell lymphoma (DLBCL). Design, Setting, Participants This nationwide, population-based cohort...
Abstract Purpose To assess and describe chemotherapy-induced peripheral neuropathy (CIPN), a well-known complication to cancer treatment, using different methodologies in hematological patients. Methods Patients scheduled for treatment with vincristine, bortezomib, or lenalidomide were included this longitudinal observational study. The patients examined CIPN before (baseline), each chemotherapy cycle, one month after end of year baseline patient-reported outcomes (Functional Assessment...
Abstract To describe the prevalence of comorbidity and its impact on survival in newly diagnosed multiple myeloma patients compared with population controls. Cases symptomatic during 2005–2012 period were identified Danish National Multiple Myeloma Registry. For each patient, 10 members general matched by age sex chosen from national Civil Registration System. Data comparison cohort collected linkage to Patient Registry (DNPR). Cox proportional hazards regression models used evaluate...
PURPOSE To address the role of consolidation treatment for newly diagnosed, transplant eligible patients with multiple myeloma in a controlled clinical trial. PATIENTS AND METHODS The EMN02/HOVON95 trial compared two cycles bortezomib, lenalidomide, and dexamethasone (VRD) or no after induction intensification therapy, followed by continuous lenalidomide maintenance. Primary study end point was progression-free survival (PFS). RESULTS Eight hundred seventy-eight were randomly assigned to...
The objectives of this study were to estimate the data quality haematological malignancy diagnoses in a hospital discharge registry, and quantify impact any misclassification on survival estimates. We included all patients > or = 15 years living North Jutland County, Denmark with first-time diagnosis registered Hospital Discharge Registry Danish Cancer Registry, reference standard, from 1994 1999. estimated completeness positive predictive value (PPV) malignancies specific subcategories, as...
Abstract Purpose The quality of patient-reported outcome (PRO) data can be compromised by non-response (NR) to scheduled questionnaires, particularly if reasons for NR are related health problems, which may lead unintended bias. aim was investigate whether electronic reminders and real-time monitoring improve PRO completion rate. Methods population-based study “Quality life in Danish multiple myeloma patients” is a longitudinal, multicentre with consecutive inclusion treatment-demanding...
Multiple myeloma (MM) patients have increased risk of developing venous thromboembolism, but the underlying mechanisms and effect on coagulation system disease current cancer therapies are not known. It is possible that cancer-associated extracellular vesicles (EV), carrying tissue factor (TF) procoagulant phospholipids (PPL) may play a role in thrombogenesis. The aim this study was to perform an in-depth analysis activity small large EVs isolated from 20 MM at diagnosis after receiving...
Abstract High proportion of patients with multiple myeloma suffer from comorbidities which may alter clinical management. Therefore, our aims were to evaluate the prevalence and their impact on survival. We included diagnosed 1990‐2013 in Sweden all diagnoses each patient 1985. A total 13 656 study, thereof 7404 (54%) had comorbidity at diagnosis. The risk death was increased for those one diagnosis compared without any (hazard ratio = 1.19; 95% confidence interval:1.14‐1.25); this higher...
Third generation oral contraceptives (OCs) are apparently stronger risk factors for venous thromboembolism (VTE) than other OCs, however, the increased may be due to confounding by indication related differences in prescription behaviour. We estimated of VTE associated with use OCs and without presence Factor V Leiden mutation, protein C-, S- or antithrombin deficiency. Sixty-seven cases were compared 134 controls. The thrombophilia was same magnitude third OC users as OCs; OR: 52.5 (95% CI:...
To evaluate the mortality and causes of death in monoclonal gammopathy undetermined significance (MGUS), we identified 1324 cases MGUS period 1978–93 North Jutland County, Denmark. Data on were obtained by record linkage to Danish Death Registry. There 868 deaths cohort during 7785 years follow‐up vs. 409·6 expected, giving a standardized ratio (SMR) 2·1 (95% confidence interval 2·0–2·3). Malignant transformation was cause 97 patients 4·9 yielding SMR 20·0 (16·2–24·4), which explained about...