A5081025867- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Breast Cancer Treatment Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Treatments and Studies
- Molecular Biology Techniques and Applications
- Surgical Simulation and Training
- Breast Lesions and Carcinomas
- Anorectal Disease Treatments and Outcomes
- Enhanced Recovery After Surgery
- Breast Implant and Reconstruction
- Gastric Cancer Management and Outcomes
- Simulation-Based Education in Healthcare
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Sepsis Diagnosis and Treatment
- Appendicitis Diagnosis and Management
- Gastrointestinal disorders and treatments
- Cancer Research and Treatments
- Nerve Injury and Rehabilitation
- Thermoregulation and physiological responses
- Colorectal and Anal Carcinomas
Aarhus University
2020-2024
Glostrup Hospital
2024
Regionshospitalet Herning
2013-2023
Regional Hospital West Jutland
2019-2022
Regional Hospital Randers
2022
Central Denmark Region
2021
Aarhus University Hospital
2006-2017
Novel sensitive methods for detection and monitoring of residual disease can improve postoperative risk stratification with implications patient selection adjuvant chemotherapy (ACT), ACT duration, intensity radiologic surveillance, and, ultimately, outcome patients colorectal cancer (CRC).To investigate the association circulating tumor DNA (ctDNA) recurrence using longitudinal data from ultradeep sequencing plasma cell-free in CRC before after surgery, during ACT, surveillance.In this...
Abstract Non-invasive approaches for cell-free DNA (cfDNA) assessment provide an opportunity cancer detection and intervention. Here, we use a machine learning model detecting tumor-derived cfDNA through genome-wide analyses of fragmentation in prospective study 365 individuals at risk lung cancer. We validate the using independent cohort 385 non-cancer 46 patients. Combining features, clinical factors, CEA levels, followed by CT imaging, detected 94% patients with across stages subtypes,...
Sensitive methods for risk stratification, monitoring therapeutic efficacy, and early relapse detection may have a major impact on treatment decisions patient management stage III colorectal cancer patients. Beyond assessing the predictive power of postoperative ctDNA detection, we explored added benefits serial analysis: adjuvant chemotherapy (ACT) growth rates.We recruited 168 patients with treated curative intent at Danish Spanish hospitals between 2014 2019. To quantify in plasma samples...
Abstract Background Early detection plays an essential role to reduce colorectal cancer (CRC) mortality. While current screening methods suffer from poor compliance, liquid biopsy-based strategies for is rapidly gaining promise. Here, we describe the development of TriMeth, a minimal-invasive blood-based test early-stage cancer. The based on assessment three tumour-specific DNA methylation markers in circulating cell-free DNA. Results A thorough multi-step biomarker discovery study profiles...
Sentinel lymph node biopsy was implemented in the treatment of early breast cancer with aim reducing shoulder and arm morbidity. Relatively few prospective studies have been published where morbidity assessed by clinical examination. Very examined impact on mobility positive patients having a secondary axillary dissection because findings metastases postoperatively.We aimed to investigate objective subjective negative patients.In study, 395 tumors less than 4 cm, were included. Patients...
OBJECTIVES: The treatment of peptic ulcer bleeding (PUB) is complex, and mortality remains high. We present results from a nationwide initiative to monitor improve the quality care (QOC) in PUB. METHODS: All Danish hospitals treating PUB patients between 2004 2011 prospectively registered demographic, clinical, prognostic data. QOC was evaluated using eight process outcome indicators, including time initial endoscopy, hemostasis obtainment, proportion undergoing surgery, rebleeding risks,...
Transcriptional characterization and classification has potential to resolve the inter-tumor heterogeneity of colorectal cancer improve patient management. Yet, robust transcriptional profiling is difficult using formalin-fixed, paraffin-embedded (FFPE) samples, which complicates testing in clinical archival material. We present MethCORR, an approach that allows uniform molecular fresh-frozen FFPE samples. MethCORR identifies genome-wide correlations between RNA expression DNA methylation...
11 Background: Timely detection of recurrence, as well identification patients at high risk recurrence after surgery and completion adjuvant therapy, are major challenges in the treatment colorectal cancer (CRC). Postsurgical circulating tumor DNA (ctDNA) analysis is a promising tool for with minimal residual disease (MRD) recurrence. The objective this prospective, multicenter study was to determine whether serial postsurgical ctDNA could identify provide an assessment therapy efficacy...
Mortality and morbidity are considerable after treatment for perforated peptic ulcer (PPU). Since 2003, a Danish nationwide quality-of-care (QOC) improvement initiative has focused on reducing preoperative delay, improving perioperative monitoring care patients with PPU. The present study reports the results of this initiative.This was cohort based prospectively collected data, involving all hospitals caring PPU in Denmark. Details treated surgically between September 2004 August 2011 were...
Objective: Circulating tumor DNA (ctDNA) is a candidate biomarker of cancer with practice-changing potential in the detection both early and residual disease. Disease stage size affect probability ctDNA detection, whereas little known about influence other characteristics on detection. This study investigates impact cell whole-genome doubling (WGD) plasma collected preoperatively from newly diagnosed colorectal (CRC) patients. Methods: WGD was estimated copy numbers derived whole-exome...
Background: A prospective study on shoulder and arm morbidity was conducted in Denmark 2003–2005. This demonstrated that sentinel lymph node biopsy associated with better outcomes than axillary dissection 18 months after surgery. We here aimed to describe subjective symptoms objective findings these patients 10+ years they underwent breast cancer surgery assess how developed during this period.Material methods: Participants the completed a questionnaire an objective, bilateral examination of...
Circulating tumour DNA (ctDNA) detection for postoperative risk stratification in cancer patients has great clinical potential. However, low ctDNA abundances complicates detection. Multitarget (MT) strategies have been developed to increase sensitivity. Yet, empirical evidence supporting performance gains of MT vs. single-target (ST) a setting is limited. We compared 379 paired plasma samples from 112 stage II-III colorectal by ST digital PCR and sequencing 16 patient-specific variants. The...
Microsatellite instability (MSI), resulting from a defective mismatch repair system, occurs in approximately 15% of sporadic colorectal cancers (CRC). Since MSI is associated with poor response to 5-fluorouracile based chemotherapy and positive predictive marker immunotherapy, it routine practice evaluate the status resected tumors CRC patients. MSIsensor novel computational tool for determining using Next Generation Sequencing. However, not widely used clinic has been independently...
AimThis study aimed to demonstrate that using a self-regulated learning (SRL) approach can improve colonoscopy performance skills.BackgroundColonoscopy is the gold standard for detecting colorectal cancer and removing its precursors: polyps. Acquiring proficiency in challenging, requiring completion of several hundred procedures. SRL seems be beneficial help trainees acquire competencies regulating their future processes enhance outcomes current situations. learner-centred refers trainee's...
Abstract Purpose After curatively intended rectal cancer (RC) surgery, new follow-up strategies are warranted, seeking more individualised care and targeting health-related quality of life (HRQoL) functional outcomes. The FURCA trial aimed to investigate the effect patient-led on HRQoL symptom burden 3 years after surgery. Methods RC patients from four Danish centres were randomised 1:1 intervention (patient-led with patient education self-referral a specialist nurse) or control (standard...
Background Intra-tumor heterogeneity (ITH) of colorectal cancer (CRC) complicates molecular tumor classification, such as transcriptional subtyping. Differences in cellular states, biopsy cell composition, and microenvironment may all lead to ITH. Here we analyze ITH at the transcriptomic proteomic levels ascertain whether subtype discordance between multiregional biopsies reflects relevant biological or lack classifier robustness. Further, study impact location on Methods Multiregional from...
To (1) develop an assessment tool for laparoscopic complete mesocolic excision (LCME) and (2) report evidence of its content validity.Assessment statements were revealed through semi-structured expert interviews consensus by the Delphi method, both involving panel five LCME surgeons. All experts interviewed then asked to rate describing from 1 (strongly disagree) 5 agree). Responses returned anonymously until was reached. Statements directly included as in if ≥60% responded "agree" or...
Diagnostic and treatment of breast cancer has steadily improved in the last decades; mammography-screening, more aggressive axillary surgery finally sentinel lymph node biopsies. This study analyses impact time trends diagnostic surgical procedures on stage at diagnosis survival three Danish counties decades.We compare extent disease outcome complete population-based patient cohorts with primary invasive cancer, diagnosed 1986, 1996-1997 2002-2003; 3 385 patients, thereby comparing...
Background. The validation series of sentinel lymph node biopsy (SLNB) in the treatment breast cancer have shown that 10–20% more metastases are detected. However, their impact has never been studied populations where method fully implemented. In a population-based setting, objective current study was to estimate increased risk after introduction technique. Methods. We identified all new patients three different counties two time periods (1996–1997 and 2002–2003). cohort comprised 2 932...
To describe 24-hour fluid administration in emergency department (ED) patients with suspected infection.A prospective, multicenter, observational study conducted three Danish hospitals, January 20 to March 2, 2020. We included consecutive adult ED infection (drawing of blood culture and/or intravenous antibiotic within 6 hours admission). Oral and fluids were registered for 24 hours.24-hour total volume. used linear regression investigate patient disease characteristics' effect on estimate...