A5039704152- Breast Cancer Treatment Studies
- Parathyroid Disorders and Treatments
- Global Cancer Incidence and Screening
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Estrogen and related hormone effects
- Bone health and osteoporosis research
- Cancer Risks and Factors
- Bone health and treatments
- Cancer Treatment and Pharmacology
- Cancer survivorship and care
- Vitamin D Research Studies
- Thyroid Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Thyroid and Parathyroid Surgery
- Colorectal Cancer Screening and Detection
- Neuroendocrine Tumor Research Advances
- BRCA gene mutations in cancer
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Ion Transport and Channel Regulation
- Advanced Breast Cancer Therapies
- Cancer-related cognitive impairment studies
- Cancer, Lipids, and Metabolism
- Reconstructive Surgery and Microvascular Techniques
Aarhus University Hospital
2016-2025
Danish Breast Cancer Cooperative Group
2014-2024
Rigshospitalet
1986-2024
Copenhagen University Hospital
2011-2024
Aarhus University
1995-2024
Sahlgrenska University Hospital
2024
Örebro University
2024
Lund University
2024
Linköping University Hospital
2024
Umeå University
2024
Extended, more effective breast cancer treatments have increased the prevalence of long-term survivors. We investigated risk late recurrence (BCR), 10 years or after primary diagnosis, and associations between patient tumor characteristics at diagnosis BCR up to 32 diagnosis.Using Danish Breast Cancer Group clinical database, we identified all women with an incident early diagnosed during 1987-2004. restricted who survived without a second (10-year disease-free survivors) followed them from...
BackgroundTrials evaluating the omission of completion axillary-lymph-node dissection in patients with clinically node-negative breast cancer and sentinel-lymph-node metastases have been compromised by limited statistical power, uncertain nodal radiotherapy target volumes, a scarcity data on relevant clinical subgroups.MethodsWe conducted noninferiority trial which primary T1 to T3 (tumor size, T1, ≤20 mm; T2, 21 50 T3, >50 mm largest dimension) one or two sentinel-node macrometastases...
ABSTRACT Objectives: To investigate self‐reported chronic pain and other sequelae in a nationally representative sample of long‐term breast cancer survivors (BCS). Design: Age‐stratified random 2,000 female BCS ≥ 5 years after primary surgery without recurrence drawn from the Danish Breast Cancer Cooperative Group register, which is regarding Denmark. Assessment: Self‐administered questionnaire including questions on sociodemography, (≥6 months), health‐related quality life (HRQOL) related...
Introduction. Since 30 years, DBCG (Danish Breast Cancer Cooperative Group) has maintained a clinical database allowing the conduct of quality control studies, randomised trials, examination epidemiology breast cancer and prognostic predictive factors. Material methods. The original included patients with invasive cancer, but later been expanded to in situ hereditary ovarian families. Results. multidisciplinary cooperative group provided successive treatment guidelines 70% 77284 registered...
Summary Background Primary hyperparathyroidism (PHPT) and vitamin D insufficiency are common conditions that can occur in combination. However, low plasma 25‐hydroxyvitamin (25OHD) may also enhance the risk of PHPT or modify disease severity. Aim To compare deficiency stratified by age, sex season between patients controls to assess associations 25OHD adenoma weight, biochemical variables, bone mineral density (BMD) clinical complications. Design Cross‐sectional study. Material A total 289...
The effect of physiotherapy on shoulder function in patients surgically treated for breast cancer was examined through a randomized controlled trial. One hundred and thirty-nine with newly diagnosed were enrolled the study. Sixty-two (45%) had Breast Conserving Therapy 77 (55%) Modified Radical Mastectomy (Axillary dissection level I II included both procedures). Enrolled to either group A or B. Group offered, team instructed consisting 12 sessions 60 min, two week. treatment instituted...
Low 25-hydroxyvitamin D levels are common in patients with primary hyperparathyroidism (PHPT) and associated higher PTH hungry bone syndrome after parathyroidectomy (PTX). However, concerns have been raised about the safety of vitamin supplementation PHPT.We aimed to assess effects on calcium homeostasis metabolism high doses PHPT patients.This was an investigator-initiated double-blind, randomized, placebo-controlled, parallel-group trial from a single center.Forty-six were recruited, mean...
The aim of the study is to compare efficacy SPIO as a tracer in sentinel node biopsy (SNB) breast cancer with Tc and patent blue multicentre prospective perform meta-analysis all published studies. It also aims follow skin discoloration after injection describe when how it resolves. Totally 206 patients early were recruited. administered standard fashion. Patients injected (Sienna+) preoperatively. SNB was performed detection rates recorded for both methods. Skin followed documented...
Background: Observational studies have pointed at a better survival after breast conserving surgery (BCS) compared with mastectomy. The aim of the present study was to evaluate whether this remains true when more extensive tumor characteristics and treatment data were included.Methods: cohort included patients registered primary for early invasive cancer in database Danish Breast Cancer Cooperative Group, period 1995–2012. divided into three groups: (i) who primarily had mastectomy, (ii)...
Abstract Genome‐wide association studies recently linked the locus for Na + ,HCO 3 − ‐cotransporter NBCn1 (SLC4A7) to breast cancer susceptibility, yet functional insights have been lacking. To determine whether NBCn1, by transporting HCO into cells, may dispose of acid produced during high metabolic activity, we studied expression and impact ‐cotransport in human cancer. We found that plasmalemmal density was 20–30% higher primary carcinomas metastases compared matched normal tissue. The...
PURPOSE Phthalate exposure is ubiquitous and especially high among users of drug products formulated with phthalates. Some phthalates mimic estradiol may promote breast cancer. Existing epidemiologic studies on this topic are small, mostly not prospective, have given inconsistent results. We estimated associations between longitudinal phthalate exposures cancer risk in a Danish nationwide cohort, using redeemed prescriptions for phthalate-containing to measure exposure. METHODS ascertained...
BACKGROUND Opioids may alter immune function, thereby potentially affecting cancer recurrence. The authors investigated the association between postdiagnosis opioid use and breast METHODS Patients with incident, early stage who were diagnosed during 1996 through 2008 in Denmark identified from Danish Breast Cancer Cooperative Group Registry. Opioid prescriptions ascertained National Prescription Follow‐up began on date of primary surgery for continued until recurrence, death, emigration, 10...
Women treated for breast cancer (BC) often suffer genitourinary syndrome of menopause. These symptoms may be alleviated by vaginal estrogen therapy (VET) or menopausal hormone (MHT). However, there are concerns risks recurrence BC and death following treatment.Our study included longitudinal data from a national cohort postmenopausal women, diagnosed 1997-2004 with early-stage invasive receptor-positive nonmetastatic BC, who received no treatment 5 years adjuvant endocrine therapy. We...
Introduction: The early randomized controlled trials revealed no differences in survival between breast-conserving surgery (BCS) and mastectomy. However, breast cancer treatment has undergone changes, the results of recent population-based registry studies suggest superior long-term after BCS. To explore current evidence, a systematic review meta-ana lysis observational from 2010 onward was conducted. Methods: A literature search conducted PubMed, Embase, Cochrane databases to identify...
Abstract Background Carbonic anhydrases catalyze CO 2 /HCO 3 – buffer reactions with implications for effective H + mobility, pH dynamics, and cellular acid–base sensing. Yet, the integrated consequences of carbonic cancer stromal cell functions, their interactions, patient prognosis are not yet clear. Methods We combine (a) bioinformatic analyses human proteomic data bulk single-cell transcriptomic coupled to clinicopathologic prognostic information; (b) ex vivo experimental studies gene...
Considering the persistent nature and higher prevalence of insomnia in cancer patients survivors compared with general population, there is a need for effective management strategies. This systematic review meta-analysis aimed to comprehensively evaluate available evidence efficacy pharmacological nonpharmacological interventions adult survivors.
Sentinel lymph node biopsy was implemented in the treatment of early breast cancer with aim reducing shoulder and arm morbidity. Relatively few prospective studies have been published where morbidity assessed by clinical examination. Very examined impact on mobility positive patients having a secondary axillary dissection because findings metastases postoperatively.We aimed to investigate objective subjective negative patients.In study, 395 tumors less than 4 cm, were included. Patients...
Lymphovascular invasion has been associated with poor prognosis in women breast cancer, but it is unclear whether the presence of lymphovascular should be considered sufficient to reclassify cancer patients who are at a low risk recurrence into high-risk category.Of 16,172 operable were entered Danish Breast Cancer Cooperative Group Registry from January 1, 1996, December 31, 2002, was classified primary diagnosis 16,121 as present (n = 2453, 15%) or absent 13,206, 82%). Patients least one...