Hans Kirkegaard
A5070874636- Cardiac Arrest and Resuscitation
- Emergency and Acute Care Studies
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Thermal Regulation in Medicine
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Respiratory Support and Mechanisms
- Ultrasound in Clinical Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Radiology practices and education
- Hemodynamic Monitoring and Therapy
- Heart Rate Variability and Autonomic Control
- Disaster Response and Management
- Heart Failure Treatment and Management
- Healthcare Systems and Technology
- Pediatric Pain Management Techniques
- Chronic Disease Management Strategies
- Airway Management and Intubation Techniques
- Family and Patient Care in Intensive Care Units
- Clinical Reasoning and Diagnostic Skills
- Non-Invasive Vital Sign Monitoring
- Nosocomial Infections in ICU
Aarhus University Hospital
2016-2025
Aarhus University
2016-2025
Central Denmark Region
2017-2024
Lund University
2022-2024
Skåne University Hospital
2024
University of Copenhagen
2023
Novo Nordisk Foundation
2023
Danish Medicines Agency
2023
Rigshospitalet
2023
Copenhagen University Hospital
2023
Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence of low certainty.In an open-label trial with blinded assessment outcomes, we randomly assigned 1900 adults coma who had out-of-hospital arrest presumed or unknown cause to undergo targeted hypothermia at 33°C, followed by controlled rewarming, normothermia early treatment fever (body temperature, ≥37.8°C). The primary outcome was death from any 6 months. Secondary outcomes included...
<h3>Importance</h3> International resuscitation guidelines recommend targeted temperature management (TTM) at 33°C to 36°C in unconscious patients with out-of-hospital cardiac arrest for least 24 hours, but the optimal duration of TTM is uncertain. <h3>Objective</h3> To determine whether 48 hours results better neurologic outcomes compared currently recommended, standard, 24-hour TTM. <h3>Design, Setting, and Participants</h3> This was an international, investigator-initiated,...
Guidelines recommend normocapnia for adults with coma who are resuscitated after out-of-hospital cardiac arrest. However, mild hypercapnia increases cerebral blood flow and may improve neurologic outcomes.We randomly assigned had been arrest of presumed or unknown cause admitted to the intensive care unit (ICU) in a 1:1 ratio either 24 hours (target partial pressure arterial carbon dioxide [Paco2], 50 55 mm Hg) Paco2, 35 45 Hg). The primary outcome was favorable outcome, defined as score 5...
Previous trials have suggested that vasopressin and methylprednisolone administered during in-hospital cardiac arrest might improve outcomes.To determine whether the combination of improves return spontaneous circulation.Multicenter, randomized, double-blind, placebo-controlled trial conducted at 10 hospitals in Denmark. A total 512 adult patients with were included between October 15, 2018, January 21, 2021. The last 90-day follow-up was on April 2021.Patients randomized to receive a (n =...
Less than 500 participants have been included in randomized trials comparing hypothermia with regular care for out-of-hospital cardiac arrest patients, and many of these were small at a high risk bias. Consequently, the accrued data on this potentially beneficial intervention resembles that drug following phase II trials. A large confirmatory trial is therefore warranted. The TTM2-trial an international, multicenter, parallel group, investigator-initiated, randomized, superiority which...
<h3>Importance</h3> Neuroprognostication studies are potentially susceptible to a self-fulfilling prophecy as investigated prognostic parameters may affect withdrawal of life-sustaining therapy. <h3>Objective</h3> To compare the results after cardiac arrest (CA) with histopathologically determined severity hypoxic-ischemic encephalopathy (HIE) obtained from autopsy results. <h3>Design, Setting, and Participants</h3> In retrospective, 3-center cohort study all patients who died following...
It is unclear whether administration of calcium has a beneficial effect in patients with cardiac arrest.To determine during out-of-hospital arrest improves return spontaneous circulation adults.This double-blind, placebo-controlled randomized clinical trial included 397 adult and was conducted the Central Denmark Region between January 20, 2020, April 15, 2021. The last 90-day follow-up on July 2021.The intervention consisted up to 2 intravenous or intraosseous doses 5 mmol chloride (n =...
Abstract Background Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values partial pressure (PaO 2 ) and episodes hypoxemia hyperoxemia occurring within first 72 h mechanical ventilation out hospital (OHCA) patients. secondary evaluate association PaO with patients’ outcome. Methods Preplanned analysis targeted hypothermia versus normothermia OHCA (TTM2) trial. Arterial blood gases were collected from...
The optimal ventilatory settings in patients after cardiac arrest and their association with outcome remain unclear. aim of this study was to describe the applied first 72 h mechanical ventilation out-of-hospital 6-month outcomes. Preplanned sub-analysis Target Temperature Management-2 trial. Clinical outcomes were mortality functional status (assessed by Modified Rankin Scale) 6 months randomization. A total 1848 included (mean age 64 [Standard Deviation, SD = 14] years). At months, 950...
Importance Despite some promising preclinical and clinical data, it remains uncertain whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia reperfusion is an effective treatment for acute stroke. Objective To evaluate the effect RIC when initiated in prehospital setting continued hospital on functional outcome patients Design, Setting, Participants This was a randomized trial conducted at 4 stroke centers Denmark that included 1500 symptoms less than hours...
The 2021 guidelines endorsed by the European Resuscitation Council (ERC) and Society of Intensive Care Medicine (ESICM) recommend using highly malignant electroencephalogram (EEG) patterns (HMEP; suppression or burst-suppression) at > 24 h after cardiac arrest (CA) in combination with least one other concordant predictor to prognosticate poor neurological outcome. We evaluated prognostic accuracy HMEP a large multicentre cohort investigated added value absent EEG reactivity. This is...
Background Because tactile evaluation is the most common form of clinical neuromuscular monitoring, this study examines relative efficacy antagonizing residual block at different levels recovery train-of-four (TOF) response. Methods Anesthesia was induced in 64 adults with 2-5 microg/kg fentanyl and 1-3 mg/kg propofol maintained fentanyl, propofol, nitrous oxide. The response adductor pollicis to TOF stimulation evaluated one arm, mechanomyographic recorded other. Patients received 0.15...
We report data from the first Utstein-style study of physician-provided pre-hospital advanced airway management. Anaesthesiologists eight critical care teams in Central Denmark Region (a mixed rural and urban region with 1.27 million inhabitants) prospectively registered according to template for reporting Data collection took place February 1st 2011 October 31st 2012. Included were patients all ages on whom management was performed. The objective estimate incidences failed difficult...
Assessment of functional ability in elderly patients is often based on self-reported rather than performance-based measures. This study aims to compare and measures a population at an emergency department (ED).Participants were 61 aged 65 years above admitted ED. The measure used was the Barthel-20; Timed Up Go (TUG); 30s-Chair Stand Test (30s-CST) Motor Process Skills (AMPS) with two scales; motor process. Correlation analyses conducted examine relationships between ability.The correlation...
BACKGROUND: The evidence for temperature control comatose survivors of cardiac arrest is inconclusive. Controversy exists as to whether the effects hypothermia differ per circumstances or patient characteristics. METHODS: An individual data meta-analysis Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest (TTM) and Hypothermia Normothermia Out-of-Hospital (TTM2) trials was conducted. intervention comparator normothermia. primary outcome all-cause mortality 6 months....
The objective of this study was to validate a previously published clinical decision rule for predicting positive blood culture in emergency department (ED) patients with suspected infection on the basis major and minor criteria total score (Shapiro et al., J Emerg Med, 2008; 35:255-264).This is retrospective matched cohort adult ED cultures obtained from 1 January 2011 through 31 December 2011. culture-confirmed bacteremia were : 3 negative cultures. outcome 'true bacteremia'. Data history,...
Dilation of the right ventricle during cardiac arrest and resuscitation may be inherent to rather than being associated with certain causes such as pulmonary embolism. This study aimed compare diameter from caused by hypovolemia, hyperkalemia, or primary arrhythmia (i.e., ventricular fibrillation).Thirty pigs were anesthetized then randomized induced three diffrent methods. Seven minutes untreated was followed resuscitation. Cardiac ultrasonographic images obtained induction arrest, The...
Acute pain is a frequent symptom, but little known about the frequency and causes of acute in prehospital population. The objectives this study were to investigate moderate severe among patients underlying according primary hospital diagnose codes. This was register-based on 41.241 transported by ambulance. Information [Numeric Rating Scale (NRS, 0–10) > 3 or higher 4-point likert scale] extracted from national electronic patient record. Patient information merged with codes based 10th...
The Targeted Hypothermia vs Normothermia After Out-of-Hospital Cardiac Arrest (TTM2) trial reported no difference in mortality or poor functional outcome at 6 months after out-of-hospital cardiac arrest (OHCA). This predefined exploratory analysis provides more detailed estimation of brain dysfunction for the comparison 2 intervention regimens.To investigate effects targeted hypothermia normothermia on with focus societal participation and cognitive function survivors OHCA.This study is a an...
The application of therapeutic hypothermia (TH) for 12 to 24 hours following out-of-hospital cardiac arrest (OHCA) has been associated with decreased mortality and improved neurological function. However, the optimal duration cooling is not known. We aimed investigate whether targeted temperature management (TTM) at 33 ± 1 °C 48 compared results in a better long-term outcome. TTH48 trial an investigator-initiated pragmatic international which patients resuscitated from OHCA are randomised...