A5086706580- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Thermal Regulation in Medicine
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Mechanical Circulatory Support Devices
- Trauma and Emergency Care Studies
- S100 Proteins and Annexins
- Disaster Response and Management
- Heart Rate Variability and Autonomic Control
- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Emergency and Acute Care Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Liver Disease Diagnosis and Treatment
- Enterobacteriaceae and Cronobacter Research
- Circular RNAs in diseases
- Antibiotic Resistance in Bacteria
- Acute Myocardial Infarction Research
- Liver Disease and Transplantation
- Anesthesia and Sedative Agents
- Thermal Expansion and Ionic Conductivity
- Veterinary Pharmacology and Anesthesia
University of Luxembourg
2022-2025
Centre Hospitalier de Luxembourg
2012-2024
Helsingborgs lasarett
2015-2022
Sahlgrenska University Hospital
2022
Lund University
2015-2022
University of Gothenburg
2022
Skåne University Hospital
2022
McMaster University
2022
Laboratoire National de Santé
2018-2021
Medical University of Vienna
2017
Unconscious survivors of out-of-hospital cardiac arrest have a high risk death or poor neurologic function. Therapeutic hypothermia is recommended by international guidelines, but the supporting evidence limited, and target temperature associated with best outcome unknown. Our objective was to compare two temperatures, both intended prevent fever.In an trial, we randomly assigned 950 unconscious adults after presumed cause targeted management at either 33°C 36°C. The primary all-cause...
Therapeutic hypothermia (TH) after cardiac arrest protects from neurological sequels and death is recommended in guidelines. The Hypothermia Registry was founded to the monitor outcome, performance complications of TH.Data on out-of-hospital (OHCA) patients admitted intensive care for TH were registered. Hospital survival long-term outcome (6-12 months) documented using Cerebral Performance Category (CPC) scale, CPC 1-2 representing a good 3-5 bad outcome.From October 2004 2008, 986...
Intensive care units (ICUs) are high-risk areas for transmission of antimicrobial-resistant bacteria, but no controlled study has tested the effect rapid screening and isolation carriers on in settings with best-standard precautions. We assessed interventions to reduce colonisation bacteria European ICUs.We did this three phases at 13 ICUs. After a 6 month baseline period (phase 1), we an interrupted time series universal chlorhexidine body-washing combined hand hygiene improvement months...
<h3>Objective:</h3> To identify reliable predictors of outcome in comatose patients after cardiac arrest using a single routine EEG and standardized interpretation according to the terminology proposed by American Clinical Neurophysiology Society. <h3>Methods:</h3> In this cohort study, 4 specialists, blinded outcome, evaluated prospectively recorded EEGs Target Temperature Management trial (TTM trial) that randomized 33°C vs 36°C. Routine was performed still rewarming. were classified into...
To assess the ability of quantitative pupillometry [using Neurological Pupil index (NPi)] to predict an unfavorable neurological outcome after cardiac arrest (CA).We performed a prospective international multicenter study (10 centers) in adult comatose CA patients. Quantitative NPi and standard manual pupillary light reflex (sPLR)-blinded clinicians assessors-were recorded parallel from day 1 3 CA. Primary endpoint was compare value versus sPLR 3-month Cerebral Performance Category (CPC),...
<h3>Importance</h3> Prognostication of neurologic outcome after cardiac arrest is an important but challenging aspect patient therapy management in critical care units. <h3>Objective</h3> To determine whether serum neurofilament light chain (NFL) levels can be used for prognostication arrest. <h3>Design, Setting and Participants</h3> Prospective clinical biobank study data from the randomized Target Temperature Management After Cardiac Arrest trial, international, multicenter with 29...
To investigate the association between adverse events recorded during critical care and mortality in out-of-hospital cardiac arrest patients treated with therapeutic hypothermia.Prospective, observational, registry-based study.Twenty-two hospitals Europe United States.Between October 2004 2008, 765 were included.None.Arrhythmias (7%-14%), pneumonia (48%), metabolic electrolyte disorders (5%-37%), seizures (24%) common period hypothermia, whereas sepsis (4%) bleeding (6%) less frequent....
Brain injury affects neurologic function and quality of life in survivors after cardiac arrest.To compare the effects 2 target temperature regimens on long-term cognitive arrest.In this multicenter, international, parallel group, assessor-masked randomized clinical trial performed from November 11, 2010, through January 10, 2013, we enrolled 950 unconscious adults with arrest presumed cause 36 intensive care units Europe Australia. Eleven patients were excluded analysis for a total sample...
To perform the first multinational Enterobacter cloacae clonality study, using MLST scheme newly developed in Japan.The analysis included 195 rectal carriage E. isolates resistant to expanded-spectrum cephalosporins (ESCs), collected from patients 12 hospital units across Europe and Israel. All of were typed by PFGE 173 subjected MLST. ESC resistance was analysed phenotypically; genes encoding ESBLs carbapenemases identified PCR sequencing.MLST distinguished 88 STs, which correlated with...
To evaluate the outcomes of cardiac arrest survivors with myoclonus receiving modern postresuscitation care.Retrospective review registry data.Cardiac centers in Europe and United States from 2002 to 2012.Two thousand five hundred thirty-two 18 years or older enrolled International Cardiac Arrest Registry.None.Eighty-eight percent patients underwent therapeutic hypothermia 471 (18%) exhibited myoclonus. Patients had longer time professional cardiopulmonary resuscitation (8.6 vs 7.0 min; p <...
Previous studies have suggested an effect of gender on outcome after out-of-hospital cardiac arrest (OHCA), but the results are conflicting. We aimed to investigate association outcome, coronary angiography (CAG) and adverse events in OHCA survivors treated with mild induced hypothermia (MIH). performed a retrospective analysis prospectively collected data from International Cardiac Arrest Registry. Adult patients non-traumatic MIH were included. Good neurological was defined as cerebral...
To test serum tau as a predictor of neurological outcome after cardiac arrest.We measured the neuronal protein in at 24, 48, and 72 hours arrest 689 patients prospective international Target Temperature Management trial. The main was poor outcome, defined Cerebral Performance Categories 3-5 6 months.Increased associated with months (median = 38.5, interquartile range [IQR] 5.7-245ng/l vs median 1.5, IQR 0.7-2.4ng/l good for hours, p < 0.0001). Tau improved prediction compared to using...
To assess the performance of a 4-step algorithm for neurological prognostication after cardiac arrest recommended by European Resuscitation Council (ERC) and Society Intensive Care Medicine (ESICM).Retrospective descriptive analysis with data from Target Temperature Management (TTM) Trial. Associations between predicted actual outcome were investigated each step results clinical examinations, neuroradiology (CT or MRI), neurophysiology (EEG SSEP) serum neuron-specific enolase. Patients...
The majority of unconscious patients after cardiac arrest (CA) do not fulfill guideline criteria for a likely poor outcome, their prognosis is considered "indeterminate". We compared brain injury markers in blood prediction good outcome and identifying false positive predictions as recommended by guidelines.
Importance Blood phosphorylated tau (p-tau) and amyloid-β peptides (Aβ) are promising peripheral biomarkers of Alzheimer disease (AD) pathology. However, their potential alterations due to alternative mechanisms, such as hypoxia in patients resuscitated from cardiac arrest, not known. Objective To evaluate whether the levels trajectories blood p-tau, Aβ42, Aβ40 following comparison with neural injury markers neurofilament light (NfL) total (t-tau), can be used for neurological...
Targeted temperature management is recommended after out-of-hospital cardiac arrest and may be achieved using a variety of cooling devices. This study was conducted to explore the performance outcomes for intravascular versus surface devices targeted arrest. A retrospective analysis data from Temperature Management trial. N = 934. total 240 patients (26%) managed with 694 (74%) Devices were assessed speed precision during induction, maintenance rewarming phases in addition adverse events....
We aimed to investigate the diagnostic performance of S100 as an outcome predictor after out-of-hospital cardiac arrest (OHCA) and potential influence two target temperatures (33 °C 36 °C) on serum levels S100.This is a substudy Target Temperature Management Out-of-Hospital Cardiac Arrest (TTM) trial. Serum were measured posteriori in core laboratory samples collected at 24, 48, 72 h OHCA. Outcome 6 months was assessed using Cerebral Performance Categories Scale (CPC 1-2 = good outcome, CPC...
Background Prediction of neurological outcome is a crucial part post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use serial measurements biomarker neuron-specific enolase (NSE) combination with other predictors admitted out-of-hospital (OHCA). This study sought to investigate ability NSE predict poor at day three OHCA. In addition, this if add...
BACKGROUND: The evidence for temperature control comatose survivors of cardiac arrest is inconclusive. Controversy exists as to whether the effects hypothermia differ per circumstances or patient characteristics. METHODS: An individual data meta-analysis Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest (TTM) and Hypothermia Normothermia Out-of-Hospital (TTM2) trials was conducted. intervention comparator normothermia. primary outcome all-cause mortality 6 months....