A5011708751- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrest and Resuscitation
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Mechanical Circulatory Support Devices
- Venous Thromboembolism Diagnosis and Management
- Biomarkers in Disease Mechanisms
- Cardiomyopathy and Myosin Studies
- Aortic Disease and Treatment Approaches
- Monoclonal and Polyclonal Antibodies Research
- Trauma Management and Diagnosis
- Cardiovascular Function and Risk Factors
- Heme Oxygenase-1 and Carbon Monoxide
- Acute Ischemic Stroke Management
- Lipoproteins and Cardiovascular Health
- Aortic Thrombus and Embolism
- Cardiac Structural Anomalies and Repair
- Case Reports on Hematomas
- Protein Tyrosine Phosphatases
- Cardiovascular Issues in Pregnancy
- Cardiovascular and exercise physiology
- Photodynamic Therapy Research Studies
Charles University
2011-2022
General University Hospital in Prague
2009-2022
Beijing Anzhen Hospital
2017
Capital Medical University
2017
Guy's and St Thomas' NHS Foundation Trust
2017
University of Iowa
2014-2016
<h3>Importance</h3> Out-of-hospital cardiac arrest (OHCA) has poor outcome. Whether intra-arrest transport, extracorporeal cardiopulmonary resuscitation (ECPR), and immediate invasive assessment treatment (invasive strategy) is beneficial in this setting remains uncertain. <h3>Objective</h3> To determine whether an early approach adults with refractory OHCA improves neurologically favorable survival. <h3>Design, Setting, Participants</h3> Single-center, randomized clinical trial Prague,...
<h3>Objective:</h3> To identify reliable predictors of outcome in comatose patients after cardiac arrest using a single routine EEG and standardized interpretation according to the terminology proposed by American Clinical Neurophysiology Society. <h3>Methods:</h3> In this cohort study, 4 specialists, blinded outcome, evaluated prospectively recorded EEGs Target Temperature Management trial (TTM trial) that randomized 33°C vs 36°C. Routine was performed still rewarming. were classified into...
AimsThe current guidelines recommend reperfusion therapy in acute myocardial infarction (AMI) with ST-segment elevation or left bundle branch block (LBBB). Surprisingly, the right (RBBB) is not listed as an indication for therapy. This study analysed patients AMI presenting RBBB [with without anterior hemiblock (LAH) posterior (LPH)] and compared them those LBBB other electrocardiographic (ECG) patterns. The aim was to describe angiographic patterns primary angioplasty use RBBB.
Survival rates in refractory out-of-hospital cardiac arrest (OHCA) remain low with conventional advanced life support (ACLS). Extracorporeal (ECLS) implantation during ongoing resuscitation, a method called extracorporeal cardiopulmonary resuscitation (ECPR), may increase survival. This study examined whether ECPR is associated improved outcomes.Prague OHCA trial enrolled adults witnessed of presumed origin. In this secondary analysis, the effect on 180-day survival using Kaplan-Meier...
The porphyrin−cyclodextrin conjugates were prepared and tested for selective effective multifunctional drug delivery therapy. porphyrin receptor system combines efficient binding of the selected to cyclodextrin cavity photosensitizing properties moiety with high accumulation whole complex in cancer tissue. combined effect chemotherapy photodynamic therapy is demonstrated by vitro vivo studies.
Background: There is no study focusing on changes in coronary atherosclerosis during dual lipid-lowering therapy with statin and ezetimibe. Methods Results: Eighty-nine patients stable angina randomized a 1:1 ratio to Group A (aggressive therapy: atorvastatin 80mg, ezetimibe 10mg) S (standard therapy) were analyzed. Treatment period was 12 months. Coronary arteries examined by intravascular ultrasound virtual histology. We found decrease the percent atheroma volume (PAV) (-0.4%) compared an...
Background The FiGARO (FFR versus iFR in Assessment of Hemodynamic Lesion Significance, and an Explanation Their Discrepancies) trial is a prospective registry searching for predictors fractional flow reserve/instantaneous wave‐free ratio (FFR/iFR) discrepancy. Methods Results FFR/iFR were analyzed using Verrata wire, coronary reserve was Combomap machine (both Philips‐Volcano). risk polymorphisms endothelial nitric oxide synthase heme oxygenase‐1 analyzed. In total, 1884 measurements from...
Coronary atherosclerosis progresses faster in patients with diabetes mellitus (DM) and causes higher morbidity mortality such compared to non-diabetics ones (non-DM). We quantify changes plaque volume phenotype during lipid-lowering therapy DM versus non-DM using advanced intracoronary imaging.We analyzed data from 61 stable angina pectoris included the PREDICT trial searching for prediction of intensive (40 mg rosuvastatin daily). Geometrically correct, fully 3-D representation vascular...
Abstract The retrograde approach in chronic total occlusion (CTO) interventions often encounters significant challenges, particularly, when aligning the microcatheter (MC) with antegrade system is difficult, complicating or even preventing standard externalization. To address these issues, techniques like “tip‐in” have proven to be effective backup strategies. We introduce “Manual Microcatheter‐tip Modification” (MMM) technique as an alternative method faces complications. present a case of...
Mutations in troponin T (TNNT2) gene represent the important part of currently identified disease-causing mutations hypertrophic (HCM) and dilated (DCM) cardiomyopathy. The aim this study was to analyze TNNT2 exons patients with HCM DCM diagnosis improve diagnostic genetic consultancy affected families. All 15 their flanking regions were analyzed by DNA sequence analysis 174 diagnosis. We variations exon 56 intron 164 patients. Two found carry unique gene. Limited screening is not suitable...
The effect of pulsatile blood flow on microcirculation during extracorporeal cardiopulmonary resuscitation (ECPR) is not elucidated; therefore, we designed an observational study comparing sublingual in patients with refractory cardiac arrest (CA) spontaneously or low/nonpulsatile after treatment ECPR. Microcirculation was assessed Sidestream Dark Field technology 12 CA who were treated ECPR and healthy control subjects. Microcirculatory images analyzed offline a blinded fashion, consensual...
The genetic basis for atherosclerosis development and progression is poorly characterized. We aimed to assess the relationship between endothelial nitric oxide synthase (ENOS) 894 G/T, haem oxygenase-1 (HO1) dinucleotide-length promoter polymorphisms coronary artery atherosclerotic invol vement its changes during statin therapy. Coronary angiography, intravascular ultrasound (IVUS), IVUS-derived virtual histology (VH) polymorphism analysis were performed at study entry. Patients randomized...
Cystatin C (CysC), an endogenous inhibitor of cysteine proteases and a sensitive accurate marker renal function, is associated with the severity coronary atherosclerosis assessed by angiography future cardiovascular events according to previous studies. We aimed evaluate association between CysC levels plaque volume, composition phenotype intravascular ultrasound ultrasound-derived virtual histology in patients preserved function. Forty-four angiographically documented artery disease...
Background and aim: To study relationships between endothelial dysfunction (ED) coronary atherosclerosis derived from intravascular ultrasound (IVUS) virtual histology (VH). Methods: Endothelial was examined by EndoPAT system (Itamar Medical) in 56 patients who underwent IVUS VH (Volcano corp.). Reactive hyperaemia index (RHI) < 2 used for definition of ED. sequences were divided into 5 mm-long non-overlapping adjacent vessel segments. Plaque phenotype determined each frame mm segment...
Tako-tsubo kardiomyopatie je relativně vzácný syndrom, pro který jsou charakteristické reverzibilní lokalizované poruchy kinetiky, zejména apikálních a středních segmentů levé komory. Velmi často imituje akutní koronární syndrom. Přesné patofyziologické mechanismy nejsou zcela známy. Za hlavní příčinu této považována silná stresová zátěž. V ojedinělých případech může být tako-tsubo způsobena i jinými faktory. Prezentujeme případ stresové vzniklý v souvislosti s léčbou anagrelidem. Anagrelid...
Background: We tested whether the level of endothelial dysfunction assessed by digital tonometry, and expressed as reactive hyperemia index (RHI), is related to occurrences a discrepancy between fractional flow reserve (FFR) instantaneous wave free ratio (iFR) (ClinicalTrials.gov identifier: NCT03033810).Methods: examined patients with coronary stenosis in range 40–70%, both FFR iFR (system Philips-Volcano) for stable angina. included consecutive one native artery, who had no previous...
Jachymova, M.; Muravska, A.; Palecek, T.; Kuchynka, P.; Rehakova, H.; Magage, S.; Kral, Zima, Horky, K.; Linhart, A. Author Information
Abstract Objective: The aim of the study was to test potential role breast arterial calcification (BAC) in prediction coronary artery disease (CAD) women. criterion standard for CAD diagnostics angiography. Methods: This retrospective enrolled 163 consecutive women, who underwent digital mammography and angiography our hospital. We assessed presence severity BAC, tested whether and/or extent BAC could be a predictor CAD, quantified by Gensini score. Results: presented 34 patients (21%)....
Východisko: Riziková stratifikace a výběr terapeutického postupu u pacientů s akutní plicní embolií (PE) jsou ztíženy nedostatkem klinických údajů z velkých prospektivních randomizovaných studií. Recentně publikovaná česká evropská doporučení diagnostiky léčby PE se liší v nomenklatuře některých aspektech rizikové stratifikace.Cíl: Autoři prezentují hypotetické srovnání obou dopad jejich odlišností na rizikovou stratifikaci toho vyplývající vlastním souboru nemocných subakutní PE.Metodika:...