A5049544841- Heme Oxygenase-1 and Carbon Monoxide
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Climate Change and Health Impacts
- Biomarkers in Disease Mechanisms
- Trace Elements in Health
- Iron Metabolism and Disorders
- Cardiovascular Disease and Adiposity
- Multiple Sclerosis Research Studies
- Air Quality and Health Impacts
- MRI in cancer diagnosis
- Neuroscience of respiration and sleep
- Veterinary medicine and infectious diseases
- RNA regulation and disease
- EEG and Brain-Computer Interfaces
- Thermal Regulation in Medicine
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Alcohol Consumption and Health Effects
- Muscle activation and electromyography studies
- Gaze Tracking and Assistive Technology
- Eicosanoids and Hypertension Pharmacology
- Travel-related health issues
- Plant Micronutrient Interactions and Effects
University of Žilina
2021
General University Hospital in Prague
2013-2017
Charles University
2006-2017
Background The FiGARO (FFR versus iFR in Assessment of Hemodynamic Lesion Significance, and an Explanation Their Discrepancies) trial is a prospective registry searching for predictors fractional flow reserve/instantaneous wave‐free ratio (FFR/iFR) discrepancy. Methods Results FFR/iFR were analyzed using Verrata wire, coronary reserve was Combomap machine (both Philips‐Volcano). risk polymorphisms endothelial nitric oxide synthase heme oxygenase‐1 analyzed. In total, 1884 measurements from...
The genetic basis for atherosclerosis development and progression is poorly characterized. We aimed to assess the relationship between endothelial nitric oxide synthase (ENOS) 894 G/T, haem oxygenase-1 (HO1) dinucleotide-length promoter polymorphisms coronary artery atherosclerotic invol vement its changes during statin therapy. Coronary angiography, intravascular ultrasound (IVUS), IVUS-derived virtual histology (VH) polymorphism analysis were performed at study entry. Patients randomized...
Menkes disease is a severe X-linked recessive disorder caused by defect in the ATP7A gene, which encodes membrane copper-transporting ATPase. Deficient activity of protein results decreased intestinal absorption copper, low copper level serum and defective distribution tissues. The clinical symptoms are activities copper-dependent enzymes include neurodegeneration, connective tissue disorders, arterial changes hair abnormalities. Without therapy, fatal early infancy. Rapid diagnosis start...
Previous studies suggested that increased activity of haem oxygenase 1 may ameliorate autoimmune neuroinflammation in experimental models multiple sclerosis. This is associated with an augmented number GT repeats (≥ 25) within the HMOX1 gene promoter. Here we examined 338 patients sclerosis to determine influence their promoter (GT) n polymorphism and other individual characteristics on course disease. The were divided into those “rapid” or “delayed” course, based reaching expanded...
Haem oxygenase 1 (HO-1) plays a pivotal role in metabolic stress protecting cells dependence on reactive oxygen species. This study investigated potential gene environment interaction between the (GT)n repeat HO1 polymorphism and perception patients with eating disorder controls. Stress were measured 127 disorders 78 healthy controls using Coping Inventory genotyping. Based inventory, overall, specific weighted scores defined. Clinical score was generated according to patient's history...
Heme oxygenase‐1 (HO‐1) is a stress protein that degrades heme to biliverdin, iron, and carbon monoxide (CO). A (GT)n dinucleotide repeat polymorphism in the HO‐1 promoter has been shown modulate gene expression. Short (<25) GT repeats are associated with up‐regulation. Multiple sclerosis (MS) an autoimmune disorder resulting CNS demyelination neurodegeneration. or exposure its end product CO counters neuroinflammation might have therapeutic potential for treatment of MS. In this study,...
Menkes disease is one of the inborn disorders copper metabolism. It an X-linked recessive caused by a defect in (ATP7A) gene which spans about 140 kb genomic DNA and contains 23 exons that encode 1500 amino acid long transmembrane copper-transporting P-type ATPase. Affected males suffer from systemic deficiency due to malabsorption defective distribution dietary resulting connective-tissue disturbance profound neurodegeneration early childhood. In this study, mutational analysis patients...
An interface based on electromyographic (EMG) signals is considered one of the central fields in human-machine (HCI) research with broad practical use. This paper presents recognition 13 individual finger movements time-frequency representation EMG via spectrograms. A deep learning algorithm, namely a convolutional neural network (CNN), used to extract features and classify them. Two approaches data representations are investigated: different window segmentation lengths reduction measured...