A5016246501- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury Research
- Antifungal resistance and susceptibility
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Arrest and Resuscitation
- Allergic Rhinitis and Sensitization
- Sarcoidosis and Beryllium Toxicity Research
- Advanced Neuroimaging Techniques and Applications
- Respiratory Support and Mechanisms
- Family and Patient Care in Intensive Care Units
- Metabolism and Genetic Disorders
- Cancer Immunotherapy and Biomarkers
- Biosensors and Analytical Detection
- Thermal Regulation in Medicine
- Lymphatic System and Diseases
- Mitochondrial Function and Pathology
- Asthma and respiratory diseases
- Airway Management and Intubation Techniques
- Neurosurgical Procedures and Complications
- Cutaneous Melanoma Detection and Management
- S100 Proteins and Annexins
University Hospital of Lausanne
2018-2023
University of Lausanne
2014-2023
Ludwig Cancer Research
2014
Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence of low certainty.In an open-label trial with blinded assessment outcomes, we randomly assigned 1900 adults coma who had out-of-hospital arrest presumed or unknown cause to undergo targeted hypothermia at 33°C, followed by controlled rewarming, normothermia early treatment fever (body temperature, ≥37.8°C). The primary outcome was death from any 6 months. Secondary outcomes included...
Increased density of tumor-associated lymphatic vessels correlates with poor patient survival in melanoma and other cancers, yet drainage is essential for initiating an immune response. Here we asked whether how vessel (LVD) cell infiltration primary tumors lymph nodes (LNs) from patients cutaneous melanoma. Using immunohistochemistry quantitative image analysis, found significant positive correlations between LVD CD8+ T as well expression the immunosuppressive molecules inducible nitric...
Adaptive metabolic response to injury includes the utilization of alternative energy substrates - such as ketone bodies (KB) protect brain against further damage. Here, we examined cerebral metabolism in patients with traumatic (TBI; n = 34 subjects) monitored microdialysis measure total interstitial tissue KB levels (acetoacetate and β-hydroxybutyrate). Nutrition from fasting vs. stable nutrition state was associated a significant decrease (34.7 [10th-90th percentiles 10.7-189] µmol/L 13.1...
Abstract Objective To evaluate the value of an adjuvant cisternostomy (AC) to decompressive craniectomy (DC) for management patients with severe traumatic brain injury (sTBI). Methods A single-center retrospective quality control analysis a consecutive series sTBI surgically treated AC or DC alone between 2013 and 2018. subgroup analysis, “primary procedure” “secondary procedure”, was also performed. We examined impact vs. on clinical outcome, including long-term (6 months) extended Glasgow...
Saliva sampling could serve as an alternative non-invasive sample for SARS-CoV-2 diagnosis while rapid antigen tests (RATs) might help to mitigate the shortage of reagents sporadically encountered with RT-PCR. Thus, in RESTART study we compared and RT-PCR testing methods on nasopharyngeal (NP) swabs salivary samples. We conducted a prospective observational among COVID-19 hospitalized patients between 10 December 2020 1 February 2021. Paired saliva NP samples were investigated by (Cobas...
Abstract Background Intensive care unit (ICU) delirium is a frequent secondary neurological complication in critically ill patients undergoing prolonged mechanical ventilation. Quantitative pupillometry an emerging modality for the neuromonitoring of primary acute brain injury, but its potential utility at risk ICU unknown. Methods This was observational cohort study medical-surgical patients, without or known who underwent sedation and ventilation least 48 h. Starting day 3, automated...
Abstract Hypertonic lactate (HL) is emerging as alternative treatment of intracranial hypertension following acute brain injury (ABI), but comparative studies are limited. Here, we examined the effectiveness HL on main cerebral and systemic physiologic variables, further compared it to that standard hypertonic saline (HS). Retrospective cohort analysis ABI subjects who received sequential osmotherapy with 7.5% HS followed by HL—given at equi-osmolar (2400 mOsmol/L) isovolumic (1.5 mL/kg)...
Introduction and aims Traumatic brain injury (TBI) often results in persistent disability, due particularly to cognitive impairments. Outcomes remain difficult predict but appear relate axonal injury. Several new approaches involving fluid neuroimaging biomarkers show promise sensitively quantify By assessing these longitudinally a large cohort, we aim both improve our understanding of the pathophysiology TBI, provide better tools clinical outcome. Methods analysis BIOmarkers AXonal after...
Abstract Objectives Saliva sampling could serve as an alternative non-invasive sample for SARS-CoV-2 diagnosis while rapid antigen testing (RAT) might help to mitigate the shortage of reagents sporadically encountered with RT-PCR. Thus, in RESTART study we compared and RT-PCR methods on nasopharyngeal (NP) swabs salivary samples. Methods We conducted a prospective observational among COVID-19 hospitalized patients between 10 th December 2020 1 st February 2021. Paired saliva NP samples were...
Abstract Background Influenza‐associated pulmonary aspergillosis (IAPA) is an important complication of severe influenza with high morbidity and mortality. Methods We conducted a retrospective multicenter study in tertiary hospitals Switzerland during 2017/2018 2019/2020 seasons. All adults PCR‐confirmed infection treatment on intensive‐care unit (ICU) for >24 h were included. IAPA was diagnosed according to previously published clinical, radiological, microbiological criteria. assessed...
Autoimmune side effects are frequent in patients with cancer treated immune checkpoint-targeting antibodies, but rare vaccines. Here, we present a case report on patient metastatic melanoma who developed pulmonary sarcoid-like granulomatosis following repetitive vaccinations peptides and CpG. Despite multiple metastases, including one lesion the brain, is alive well more than 13 years after diagnosis of disease. The strongly activated tumor-specific CD8(+) T cells showed robust long-term...
Nociceptive assessment in deeply sedated patients is challenging. Validated instruments are lacking for this unresponsive population. Videopupillometry a promising tool but has not been established intensive care settings.
Background Traumatic brain injury (TBI) is associated with the tauopathies Alzheimer’s disease and chronic traumatic encephalopathy. Advanced immunoassays show significant elevations in plasma total tau (t-tau) early post-TBI, but concentrations subsequently normalise rapidly. Tau phosphorylated at serine-181 (p-tau181) a well-validated marker that could potentially seed progressive neurodegeneration. We tested whether post-traumatic p-tau181 are elevated relate to atrophy. Methods Plasma...
Deep sedation may be indicated in the intensive care unit (ICU) for management of acute organ failure, but leads to sedative-induced delirium. Whether processed electroencephalography (p-EEG) is useful this setting unclear.We conducted a single-centre observational study non-neurological ICU patients sedated according standardized guideline deep (Richmond Agitation Sedation Scale [RASS] between -5 and -4) during phase respiratory and/or cardio-circulatory failure. The SedLine (Masimo...
Awake prone positioning (aPP) in non-intubated patients with severe SARS-CoV-2-related pneumonia improves oxygenation and reduces the intubation rate, but no early predictors for success or failure of strategy have been described. The main objective this study was to assess whether response first aPP terms PaO2/FiO2, alveolar-arterial gradient (Aa-O2), respiratory rate PaCO2 could predict need intubation. As secondary objective, we assessed effects on same parameters all sessions considered...
Abstract Background. Intensive care unit (ICU) delirium is a frequent secondary neurological complication in critically ill patients undergoing prolonged mechanical ventilation. Quantitative pupillometry an emerging modality for the neuromonitoring of primary acute brain injury, but its potential utility at risk ICU unknown. Methods. This was observational cohort study medical-surgical patients, without or known who underwent sedation and ventilation least 48 hours. Starting day 3, automated...
Abstract Background. Intensive care unit (ICU) delirium is a frequent secondary neurological complication in critically ill patients undergoing prolonged mechanical ventilation. Quantitative pupillometry an emerging modality for the neuromonitoring of primary acute brain injury, but its potential utility at risk ICU unknown. Methods. This was observational cohort study medical-surgical patients, without or known who underwent sedation and ventilation least 48 hours. Starting day 3, automated...
Background: Influenza-associated pulmonary aspergillosis (IAPA) is an important complication of severe influenza with high morbidity and mortality. Methods: We conducted a retrospective multicenter study in tertiary hospitals Switzerland during 2017/18 2019/20 seasons. All adults PCR-confirmed infection treatment on intensive-care unit (ICU) for >24h were included. IAPA was diagnosed according to previously published clinical, radiological microbiological criteria. assessed risk factors...