A5060143955- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Thermal Regulation in Medicine
- Intensive Care Unit Cognitive Disorders
- Mechanical Circulatory Support Devices
- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma and Emergency Care Studies
- Electrolyte and hormonal disorders
- Traumatic Brain Injury Research
- Heart Rate Variability and Autonomic Control
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Effects of Exercise
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Heart Failure Treatment and Management
- Cardiac Ischemia and Reperfusion
- Contact Dermatitis and Allergies
- Trauma Management and Diagnosis
- Acute Ischemic Stroke Management
- Non-Invasive Vital Sign Monitoring
- Pediatric Pain Management Techniques
- Renal cell carcinoma treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- S100 Proteins and Annexins
Aarhus University Hospital
2015-2025
Aarhus University
2016-2023
Regional Hospital West Jutland
2020-2021
Odense University Hospital
2009
Copenhagen University Hospital
2009
<h3>Importance</h3> International resuscitation guidelines recommend targeted temperature management (TTM) at 33°C to 36°C in unconscious patients with out-of-hospital cardiac arrest for least 24 hours, but the optimal duration of TTM is uncertain. <h3>Objective</h3> To determine whether 48 hours results better neurologic outcomes compared currently recommended, standard, 24-hour TTM. <h3>Design, Setting, and Participants</h3> This was an international, investigator-initiated,...
Low serum sodium has recently been associated with poor survival in localised renal cell carcinoma (RCC). We now show the prognostic effect of patients metastatic RCC (mRCC).Cohort A comprised 120 consecutive mRCC receiving subcutaneous, low-dose interleukin-2 and interferon-alpha. Hyponatremia was assessed univariate multivariate analyses. An independent cohort another used for validation (cohort B).In A, estimated 5-year 15% median 15.1 months. Serum ranged between 126 144 mM. Twenty-four...
Objective: Hemorrhagic and thromboembolic complications are common during support with extracorporeal membrane oxygenation (ECMO). As platelets play a pivotal role in hemostasis, we aimed to clarify how ECMO affects platelet function. Methods: We included 33 adult patients undergoing at tertiary ECMO-referral center Aarhus University Hospital, Denmark. Blood samples were collected on the first morning following initiation, subsequently every until 7th (+/-1) day. Platelet aggregation was...
Describe the relationship between ICU-acquired hypernatremia and in-hospital mortality investigate optimal correction rate.Observational study including two individual ICU cohorts. We used Medical Information Mart for Intensive Care III v. 1.4 database consists of all patients admitted to Beth Israel Deaconess Center in Boston from 2001 2012 (n = 46,476). The electronic 2.0 208 distinct hospitals across United States 2014 2015 200,859). included adult an with consecutive sodium samples...
Coagulation can be visualised using whole blood coagulation analyses such as thromboelastometry and platelet aggregation tests; however, the role of temperature in is ambiguous. The aim was to examine whether influences tests. We included 40 patients treated with targeted management (33 ± 1 °C) after out-of-hospital cardiac arrest. samples were obtained on hypothermia normothermia. Each sample analysed simultaneously at 33 °C 37 by thromboelastography (ROTEM®) employing assays EXTEM®,...
Abstract Background Comatose patients admitted after out-of-hospital cardiac arrest frequently experience haemodynamic instability and anoxic brain injury. Targeted temperature management is used for neuroprotection; however, targeted also affects patients’ status. This study assessed the status of survivors during prolonged (48 hours) at 33°C. Methods Analysis vasopressor data from 311 included in a randomised, clinical trial conducted 10 European hospitals (the TTH48 trial). Patients were...
This study investigated changes in coagulation and associations with occurrence of bleeding thrombosis during extracorporeal membrane oxygenation (ECMO) therapy. The included 100 adult ECMO-patients. Standard parameters, platelet aggregation thromboelastometry (ROTEM®) were compared healthy controls. Data on collected until recovery or death. Mortality data 30 days after weaning from ECMO. During ECMO therapy, 53 patients experienced at least one moderate major bleed. Among these, 42 (79%)...
BackgroundPatients surviving out-of hospital cardicac arrest, with good neurological outcome according to Cerebral Performance Category, frequently have neuropsychological impairment. We studied whether biomarker data (S-100b and neuron-specific enolase) obtained during the ICU stay predicted cognitive impairment 6 months after resuscitation.MethodsPatients (N = 79) a CPC-score ≤2 were recruited from two trial sites taking part in TTH48 comparing targeted temperature management (TTM) for 48...
Electrolyte disturbances can result from targeted temperature treatment (TTM) in out-of-hospital cardiac arrest (OHCA) patients. This study explores electrolyte changes blood and urine OHCA patients treated with TTM.This is a sub-study of the TTH48 trial, inclusion 310 unconscious TTM at 33°C for 24 or 48 h. Over three-day period, serum concentrations were obtained on sodium potassium, chloride, ionized calcium, magnesium phosphate, as results 24-h diuresis concentration excretion. Changes...
Abstract Background Quantitative pupillometry is an objective method to examine pupil reaction and subsequently grade the response on a neurological index (NPi) scale from 0 5. The aim of present sub‐study was explore long‐term prognostic value NPi in comatose out‐of‐hospital cardiac arrest patients undergoing targeted temperature management (TTM). Methods This planned “Targeted for 48 versus 24 h outcome after arrest: A randomized clinical trial.” assessed admission throughout day 3 linked...
Some studies conclude that mild hypothermia causes platelet dysfunction leading to an increased bleeding risk, whereas others state aggregation is enhanced during hypothermia. Therefore, the aim of this study was clarify whether standard or prolonged duration targeted temperature management affected aggregation. We randomised 82 comatose patients resuscitated after out-of-hospital cardiac arrest either 24 hours (standard group) 48 (prolonged at 33±1°C. Blood samples were collected 22 hours,...
Abstract Background Transthoracic echocardiographic (TTE) indices of myocardial function among survivors out-of-hospital cardiac arrest (OHCA) have been related to neurological outcome; however, results are inconsistent. We hypothesized that changes in average peak systolic mitral annular velocity (s’) from 24 h (h) 72 following start targeted temperature management (TTM) predict six-month outcome comatose OHCA survivors. Methods investigated the association between plane and a population 99...