A5010974158- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Dietary Effects on Health
- Colorectal and Anal Carcinomas
- Anorectal Disease Treatments and Outcomes
- Diabetes Treatment and Management
- Diet and metabolism studies
- Stoma care and complications
- Diet, Metabolism, and Disease
- Cardiac, Anesthesia and Surgical Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Pancreatic function and diabetes
- Circadian rhythm and melatonin
- Regulation of Appetite and Obesity
- Digestive system and related health
- Ion Transport and Channel Regulation
- MicroRNA in disease regulation
- Surgical Simulation and Training
- Circular RNAs in diseases
- Congenital heart defects research
- Gastrointestinal motility and disorders
- Appendicitis Diagnosis and Management
- Hip and Femur Fractures
- Trauma and Emergency Care Studies
Norfolk and Norwich University Hospitals NHS Foundation Trust
2018-2025
Norfolk and Norwich University Hospital
2017-2024
University of East Anglia
2019-2023
Norwich Research Park
2022
The Christie NHS Foundation Trust
2018
The Christie Hospital
2018
St Mark's Hospital
2018
Brigham and Women's Hospital
2007-2012
University of Oxford
2002-2012
Harvard University
2007-2012
In Brief Objective: We set out to examine the short-term regulation of intestinal sodium/glucose cotransporter SGLT1 by its substrate glucose and sweet taste analogs. Summary Background Data: Intestinal is a putative target for antidiabetic therapy; however, physiological incompletely understood, limiting application as pharmacological target. While it clearly regulated dietary composition over period days, nutrients unknown. Methods: Sprague-Dawley rats were anesthetized, duodenum...
Roux-en-Y gastric bypass (RYGB) has become the gold-standard bariatric procedure, partly because of rapid resolution accompanying diabetes. There is increasing evidence this mediated by duodenal exclusion. We hypothesize that exclusion suppresses intestinal Na(+)/glucose cotransporter SGLT1-mediated glucose transport, improving handling, and aimed to test in a rodent RYGB model. Sprague-Dawley rats underwent sham procedure or (10 cm Roux, 16 biliopancreatic limbs). Animals were maintained...
Abstract Aim High stoma output and dehydration is common following ileostomy formation. However, the impact of this on renal function, both in short term after reversal, remains poorly defined. We aimed to assess independent kidney function an rectal cancer surgery subsequent reversibility closure. Methods This retrospective single‐site cohort study identified patients undergoing resection from 2003 2017, with or without a diverting ileostomy. Renal was calculated preoperatively, before...
Perianal abscess is common. Traditionally, postoperative perianal cavities are managed with internal wound packing, a practice not supported by evidence. The aim of this randomized clinical trial (RCT) was to assess if non-packing less painful and it associated adverse outcomes.The Postoperative Packing Abscess Cavities (PPAC2) multicentre, RCT (two-group parallel design) adult participants admitted an NHS hospital for incision drainage primary abscess. Participants were 1:1 (via online...
Abstract Aim Complete mesocolic excision (CME) for colon cancer has been associated with improved oncological outcomes but requires a detailed understanding of complex mesenteric vasculature. Three‐dimensional (3D) reconstructed models derived from patient imaging could enhance preoperative anatomical comprehension, enabling safer, precision CME. Methods In this two‐phase, blinded, crossover study, four expert CME surgeons evaluated vascular anatomy on CT scans and 3D models. phase 1,...
BACKGROUND: Surgical and systemic therapies continue to advance, enabling restorative resections for distal rectal cancer. These operations are associated with low anterior resection syndrome. Recent studies methodological size limitations have investigated the incidence of syndrome after resection. However, long-term trajectory its effect on health-related quality life remain unclear. OBJECTIVE: The purpose this study was assess impact reversal ileostomy DESIGN: Patient demographics were...
Minimally invasive right hemicolectomy (MIRH) is the cornerstone of treatment for patients with right-sided colon cancer. This operation has evolved during recent decades, many innovations and improvements but this also resulted in high variability uptake subsequent substantial variableness. The aim ongoing study to identify current surgical variations, determine most optimal standardised MIRH nationally train implement that technique improve short-term clinical long-term oncological...
the intestinal Na(+)/glucose cotransporter (SGLT1) displays rapid anticipatory diurnal rhythms in mRNA and protein expression. The vagus nerve has been implicated entrainment of some transporters. We aimed to clarify influence on pathway for SGLT1 examine role vagal afferent fibers.male Sprague-Dawley rats were randomized three groups, total subdiaphragmatic vagotomy, selective deafferentation with capsaicin, or sham laparotomy. Postoperatively, animals maintained a 12-h light-dark cycle...
To determine the tissue penetration of vancomycin into perivascular fat and arterial wall during a continuous infusion vancomycin, given as prophylaxis for vascular surgery.Patients undergoing reconstruction requiring antibiotic were included. Patients received loading evening prior to surgery followed by 24 h infusion, calculated according renal function. Three peri-operative serum samples intra-operative collected assay.Twenty-eight patients obtained from all patients, available 27 (96.4%)...
Short bowel syndrome remains a condition of high morbidity and mortality, current therapeutic options carry significant side effects. To identify new treatments we focused on postresection changes in microRNAs--short noncoding RNAs, which suppress target genes--and suggest previously undiscovered role for microRNA-125a (mir-125a) intestinal adaptation.Rats underwent either 80% massive small resection or transection were harvested after 48 hours. Jejunum was microRNA microarrays, laser...
To (1) develop an assessment tool for laparoscopic complete mesocolic excision (LCME) and (2) report evidence of its content validity.Assessment statements were revealed through semi-structured expert interviews consensus by the Delphi method, both involving panel five LCME surgeons. All experts interviewed then asked to rate describing from 1 (strongly disagree) 5 agree). Responses returned anonymously until was reached. Statements directly included as in if ≥60% responded "agree" or...