A5065370427- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Reactions
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Organic Chemistry Cycloaddition Reactions
- Carbohydrate Chemistry and Synthesis
- Coordination Chemistry and Organometallics
- Sulfur-Based Synthesis Techniques
- Catalytic Cross-Coupling Reactions
- Fluorine in Organic Chemistry
- Parasitic Diseases Research and Treatment
- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Oxidative Organic Chemistry Reactions
- Cyclopropane Reaction Mechanisms
- Chemical Reaction Mechanisms
- Vanadium and Halogenation Chemistry
- Crystallography and molecular interactions
- Synthesis of heterocyclic compounds
- Parasite Biology and Host Interactions
- Global Peace and Security Dynamics
- Synthesis and Biological Evaluation
University of Sheffield
2011-2023
University of Liverpool
2022-2023
University of Michigan
2022
Royal Liverpool University Hospital
2022
AstraZeneca (United Kingdom)
2022
Vermont College of Fine Arts
2021
University of Bath
2021
SUNY Downstate Health Sciences University
2018-2021
University of Tennessee at Chattanooga
2019-2021
University of Chicago
2021
OBJECTIVE This trial compared the efficacy and safety of first oral glucagon-like peptide 1 (GLP-1) receptor agonist, semaglutide, as monotherapy with placebo in patients type 2 diabetes managed by diet exercise alone. Two estimands addressed two efficacy-related questions: a treatment policy estimand (regardless product discontinuation or rescue medication use) (on without all randomized patients. RESEARCH DESIGN AND METHODS was 26-week, phase 3a, randomized, double-blind,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of enantiomerically pure protected 4-oxo .alpha.-amino acids and 3-aryl from serineRichard F. W. Jackson, Neil Wishart, Anthony Wood, Keith James, Martin J. WythesCite this: Org. Chem. 1992, 57, 12, 3397–3404Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/jo00038a030https://doi.org/10.1021/jo00038a030research-articleACS PublicationsRequest...
The importance of the mix: use chloroform as solvent, ligand (R)-2 and [VO(acac)2] catalyst, H2O2 oxidant promotes highly enantioselective oxidation simple alkyl aryl sulfides 1 to give sulfoxides (R)-3 (see scheme). success this process partly derives from an efficient kinetic resolution product sulfoxides.
A new, efficient use for that most venerable chiral ligand, diethyl tartrate: Chalcone derivatives 1 can be converted, as shown below, into the corresponding epoxy ketones (−)-2 with good to excellent enantiomeric excess by using tert-butyl hydroperoxide in presence of catalytic amounts dibutylmagnesium (10 mol%) and (+)-diethyl tartrate (11 mol%).
The purpose of this study was to identify risk factors predict caries progression in toddlers primary-healthcare settings for the cost-effective targeting preventive and referral strategies. We examined 329 children (26 ± 6 mos old) twice, one year apart, Indiana, USA. A 107-item structured interview used collect information from primary caregiver child on factors/beliefs/perceptions/behaviors that could affect development, transmission bacteria, medical-dental health, access care. Bacterial...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Enantiomerically Pure Unsaturated .alpha.-Amino Acids Using Serine-Derived Zinc/Copper ReagentsMichael J. Dunn, Richard F. W. Jackson, Joerg Pietruszka, and Debra TurnerCite this: Org. Chem. 1995, 60, 7, 2210–2215Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/jo00112a048https://doi.org/10.1021/jo00112a048research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTInvestigation of a New Family Chiral Ligands for Enantioselective Catalysis via Parallel Synthesis and High-Throughput ScreeningCesare Gennari, Simona Ceccarelli, Umberto Piarulli, Christian A. G. N. Montalbetti, Richard F. W. JacksonView Author Information Università di Milano, Dipartimento Chimica Organica e Industriale, Centro CNR per lo Studio delle Sostanze Organiche Naturali, Venezian 21, I-20133 Italy, Istituto Scienze Mat. Fis....
Protected phenylalanines 23 (seven examples), homophenylalanines 7 (eight and bishomophenylalanines 8 examples) have been prepared by palladium-catalyzed coupling of the amino acid-derived organozinc reagents 13, 5, 6, respectively, with aryl iodides. While reactions zinc reagent 13 may be conducted in both THF DMF as solvent, results obtained are generally superior. In case 5 6 far superior DMF. NMR investigations on structure suggest that there is strong intramolecular coordination...
Abstract The macrodiolide antibiotic elaiophylin ( 6 , Scheme 1) is converted into an aglycone 8a by acid‐catalysed cleavage of the deoxyfucoses in methanol, with replacement two lactol OH‐groups OCH 3 (C‐11 and C‐11′). di‐ O ‐methylelaiophylidene ), a C 2 ‐symmetrical × 11 stereogenic units, was synthesised from R )‐3‐hydroxy‐butanoate (from biopolymer PHB) S )‐malic ester, using diastereoselective steps for generation other units. key intermediates (Scheme 2) are macrocyclic dialdehyde 10...
A combination of Pd2(dba)3 and SPhos (1:2 molar ratio) is an excellent precatalyst for the Negishi cross-coupling serine-derived organozinc reagent 2 with aryl halides, including previously difficult ortho-substituted examples. In case meta- para-substituted Pd-loadings 0.5 mol % give satisfactory results. Use 2-iodoaniline as substrate gives lactam 12 in good yield.
Hydrolyzed inulin has previously been shown by Jackson and Goergen (RP79) to contain about 5 per cent of a group nonreducing difructoses, one which was isolated in crystalline form found be difructose anhydride [a] p = + 27.0.The mother liquors from this substance had crystallized ultimately yielded crystallization alcoholic solution second crys- talline substance, designated II, third, III.Difructose II crystallizes truncated prisms, frequently having hexagonal cross section, melts at...
Perianal abscess is common. Traditionally, postoperative perianal cavities are managed with internal wound packing, a practice not supported by evidence. The aim of this randomized clinical trial (RCT) was to assess if non-packing less painful and it associated adverse outcomes.The Postoperative Packing Abscess Cavities (PPAC2) multicentre, RCT (two-group parallel design) adult participants admitted an NHS hospital for incision drainage primary abscess. Participants were 1:1 (via online...
Two libraries of chiral Schiff base ligands were synthesised and screened in the vanadium-catalysed oxidation alkyl aryl sulfides with hydrogen peroxide as terminal oxidant. The vanadium-chiral complex 10, readily prepared from 3,5-diiodo-salicylaldehyde (S)-tert-leucinol, was found to be highly enantioselective. Optically active sulfoxides could thus obtained good yields up 97% ee.
The organozinc reagent (2), prepared from the protected β-iodo alanine derivative (3) using ultrasonic activation, is efficiently acylated acid chlorides in presence of (Ph3P)2PdCl2 to give high yields enantiomerically pure γ-keto α-amino acids (4).
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (+)-11,11'-di-O-methylelaiophylidene, an aglycon elaiophylinDieter Seebach, Hak Fun Chow, Richard Jackson, Kevin Lawson, Marius Sutter, Suvit Thaisrivongs, and Juerg ZimmermannCite this: J. Am. Chem. Soc. 1985, 107, 18, 5292–5293Publication Date (Print):September 1, 1985Publication History Published online1 May 2002Published inissue 1 September...
Fundamental physical properties of levulose have been determined in order to facilitate its quantitative determination.Densities aqueous solutions are given at 20°and 25°C.for concentrations 70 per cent.Expansions measured over a 50°temperature interval.The density crystalline is shown be 1.598.Refractive indices 25°C.between and 90 cent concentration.The saccharimetric rotations 25°and the change rotation 50°interval temperature determined.1.