A5033229659- Osteoarthritis Treatment and Mechanisms
- Scoliosis diagnosis and treatment
- Bone health and osteoporosis research
- Total Knee Arthroplasty Outcomes
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Cerebral Palsy and Movement Disorders
- Bone fractures and treatments
- Bone health and treatments
- Knee injuries and reconstruction techniques
- Neurogenetic and Muscular Disorders Research
- Medical Imaging and Analysis
- Management of metastatic bone disease
- Veterinary Equine Medical Research
- Hip and Femur Fractures
- Inflammatory mediators and NSAID effects
- Bone and Joint Diseases
- Medical Imaging Techniques and Applications
- Congenital Diaphragmatic Hernia Studies
- Nuclear Structure and Function
- Spinal Dysraphism and Malformations
- Pelvic and Acetabular Injuries
- Orthopedic Infections and Treatments
Boston Children's Hospital
2016-2025
Beth Israel Deaconess Medical Center
2016-2025
Harvard University
2015-2024
Boston Children's Museum
2014-2024
Gillette Children's Specialty Healthcare
2024
Southwestern University
2024
Orthopedic Center
2016-2021
Children's Hospital of Philadelphia
2021
Boston University
2008-2019
Orthopedic One
2018-2019
• Five patients had progressive dementia heralded by disorders of higher visual function. All eventually developed alexia, agraphia, agnosia, and components Balint's, Gerstmann's, transcortical sensory aphasia syndromes. Memory, insight, judgment were relatively preserved until late in the course. Predominant parieto-occipital atrophy was demonstrated on both computed tomography magnetic resonance imaging two patients; posterior circulation normal angiography three studied. To date, no...
This is the second half of a two-part document updating standard care recommendations for spinal muscular atrophy published in 2007. part includes updated on pulmonary management and acute issues, topics that have emerged last few years such as other organ involvement severe forms role medications. Ethical issues choice palliative versus supportive are also addressed. These becoming increasingly relevant given recent clinical trials prospect commercially available therapies will likely...
Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare, fatal, segmental premature aging caused by a mutation in LMNA that produces the farnesylated aberrant lamin A protein, progerin. This multisystem disorder causes failure to thrive and accelerated atherosclerosis leading early death. Farnesyltransferase inhibitors have ameliorated disease phenotypes preclinical studies. Twenty-five patients with HGPS received farnesyltransferase inhibitor lonafarnib for minimum of 2 y. Primary...
OBJECTIVE This trial compared the efficacy and safety of first oral glucagon-like peptide 1 (GLP-1) receptor agonist, semaglutide, as monotherapy with placebo in patients type 2 diabetes managed by diet exercise alone. Two estimands addressed two efficacy-related questions: a treatment policy estimand (regardless product discontinuation or rescue medication use) (on without all randomized patients. RESEARCH DESIGN AND METHODS was 26-week, phase 3a, randomized, double-blind,...
Background: Early-onset scoliosis is a heterogeneous condition, with highly variable manifestations and natural history. No standardized classification system exists to describe group patients, guide optimal care, or prognosticate outcomes within this population. A for early-onset thus necessary prerequisite the timely evolution of care these patients. Methods: Fifteen experienced surgeons participated in nominal technique designed achieve consensus-based scoliosis. comprehensive list...
Gold nanoparticles have shown potential in photothermal cancer therapy and optoelectronic technology. In both applications, a call for small size nanorods is warranted. the present work, one-pot seedless synthetic technique has been developed to prepare relatively monodisperse gold with average dimensions (length × width) of 18 4.5 nm, 25 5 15 10 2.5 nm. this method, pH was found play crucial role monodispersity when NaBH(4) concentration growth solution adjusted control reduction rate ions....
OBJECTIVE To investigate the efficacy, safety, and tolerability of oral semaglutide added to insulin with or without metformin. RESEARCH DESIGN AND METHODS Patients type 2 diabetes uncontrolled on metformin were randomized 3 mg (N = 184), 7 182), 14 181) placebo 184) in a 52-week, double-blind trial. End points change from baseline week 26 HbA1c (primary) body weight (confirmatory secondary). Two estimands defined: treatment policy (effect regardless trial product discontinuation rescue...
Exacerbated by an aging population, musculoskeletal diseases are a chronic and growing problem in the United States that impose significant health economic burdens. The objective of this study was to analyze correlation between burden federal funds assigned health-related research through National Institutes Health (NIH). An ecological design used examine relationship NIH funding disease for 60 categories. We Global Burden Disease (GBD) Study 2019 measure Research, Condition, Categories...
Abstract The anterior cruciate ligament (ACL) fails to heal after suture repair. One hypothesis for this failure is the premature loss of fibrin clot, or provisional scaffolding, between two ends in joint environment. To test hypothesis, a substitute scaffold collagen–platelet rich plasma (PRP) hydrogel was used fill ACL wound site at time repair and structural properties healing ACLs evaluated 4 weeks surgery. Bilateral transections were performed five 30‐kg Yorkshire pigs treated with In...
Background: Closed reduction and percutaneous pin fixation is the treatment of choice for completely displaced (type-III) extension supracondylar fractures humerus in children, although controversy persists regarding optimal pin-fixation technique. The purpose this study was to compare efficacy lateral entry with that medial operative children. Methods: This prospective, randomized clinical trial had sufficient power detect a 10% difference rate loss between two groups. techniques were...
Hutchinson-Gilford progeria syndrome is an extremely rare, fatal, segmental premature aging caused by a mutation in LMNA yielding the farnesylated aberrant protein progerin. Without progerin-specific treatment, death occurs at average age of 14.6 years from accelerated atherosclerosis. A previous single-arm clinical trial demonstrated that farnesyltransferase inhibitor lonafarnib ameliorates some aspects cardiovascular and bone disease. This present sought to further improve disease...
Although cerebral palsy (CP) is among the most common causes of physical disability in early childhood, we know little about functional and structural changes this disorder developing brain. Here, investigated with three different neuroimaging modalities [magnetoencephalography (MEG), diffusion tensor imaging (DTI), resting-state fMRI] whether spastic CP associated anatomical abnormalities sensorimotor network. Ten children participated study: four diplegic (DCP), hemiplegic (HCP), typically...
Background Controversy continues regarding the appropriate assessment of fracture risk in long bone lesions affected by disseminated malignancy. Questions/purposes The purpose this ongoing Musculoskeletal Tumor Society-sponsored, multi-institutional prospective cross-sectional clinical study is to compare CT-based structural rigidity analysis (CTRA) with physician-derived Mirels scoring for predicting pathologic femoral lesions. We hypothesized CTRA would be superior within first year based...
Abstract Objectives Cerebral palsy (CP) is the most common childhood motor disability, yet its link to single‐gene disorders under‐characterized. To explore genetic landscape of CP, we conducted whole exome sequencing (WES) in a cohort patients with CP. Methods We performed comprehensive phenotyping and WES on prospective individuals cryptogenic CP (who meet criteria for CP; have no risk factors), non‐cryptogenic at least one factor), masqueraders could be diagnosed but...
BackgroundSARS-CoV-2 binding to ACE2 is potentially associated with severe pneumonia due COVID-19. The aim of the study was test whether Mas-receptor activation by 20-hydroxyecdysone (BIO101) could restore Renin-Angiotensin System equilibrium and limit frequency respiratory failure mortality in adults hospitalized COVID-19.MethodsDouble-blind, randomized, placebo-controlled phase 2/3 trial. Randomization: 1:1 oral BIO101 (350 mg BID) or placebo, up 28 days until an endpoint reached. Primary...
Thirty-four patients were enrolled in a prospective randomized study comparing cast immobilization alone versus percutaneous pin fixation following closed reduction of distal radial metaphyseal fractures. Patients older than 10 years age with greater 30 degrees dorsal angulation or complete fracture displacement eligible for enrollment. Average follow-up was 10.5 weeks. All fractures healed uneventfully without deformity, growth arrest, functional limitations. Overall complication rates...
Background: Closed reduction and percutaneous pin fixation is the treatment of choice for completely displaced (type-III) extension supracondylar fractures humerus in children, although controversy persists regarding optimal pin-fixation technique. The purpose this study was to compare efficacy lateral entry with that medial operative children. Methods: This prospective, randomized clinical trial had sufficient power detect a 10% difference rate loss between two groups. techniques were...